Browse Items (23 total)
- Tags: Protein Binding
Tags: *Disease Susceptibility, *Signal Transduction, 2018, Animals, Carrier Proteins/chemistry/genetics/*metabolism, Gene Expression Regulation, Humans, Hussein Nazar J, International journal of molecular medicine, Mbimba Thomas, Najeed Ayesha, Protein Binding, Protein Interaction Domains and Motifs, Protein Transport, Safadi Fayez F, Structure-Activity Relationship
Tags: 2001, Base Sequence, Binding, Binding Sites/genetics, Cell Line, Chiang J Y, Competitive, CpG Islands/genetics, Cultured, Cytochrome P-450 Enzyme System/*genetics/metabolism, Cytochrome P450 Family 7, Department of Integrative Medical Sciences, DNA/genetics, Enzymologic, gene, Gene Expression Regulation, Genetic, Humans, Luciferases/genetics/metabolism, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid/genetics, Protein Binding, Recombinant Fusion Proteins/genetics/metabolism, Regulatory Sequences, Sequence Deletion, Site-Directed, Sp1 Transcription Factor/metabolism/*physiology, Steroid Hydroxylases/*genetics/metabolism, Transcription, Transfection, Tumor Cells, Wu Z
Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.
Tags: *DNA-Binding Proteins, *Regulatory Sequences, 2000, Animals, Anticholesteremic Agents/pharmacology, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Binding Sites, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/biosynthesis/*genetics, Clofibric Acid/pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Enzymologic, Gene Expression Regulation, Genes, Genetic, Hepatocyte Nuclear Factor 4, Humans, Journal of lipid research, Liver/metabolism, Marrapodi M, Models, NEOMED College of Medicine, Nucleic Acid, Peroxisome Proliferators/pharmacology, Phosphoproteins/metabolism, Promoter Regions, Protein Binding, Pyrimidines/pharmacology, Rats, Receptors, Reporter, Response Elements, Retinoic Acid/metabolism, Retinoid X Receptors, Species Specificity, Transcription, Transcription Factors/*agonists/metabolism, Transcriptional Activation
Tags: 2012, Cytoplasmic and Nuclear/antagonists & inhibitors/*metabolism, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, DNA/metabolism, Drug Evaluation, Future medicinal chemistry, Humans, Ligands, MicroRNAs/metabolism, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Peptides/chemistry/pharmacology, Preclinical, Protein Binding, Receptors, Sadana Prabodh, Signal Transduction/drug effects, Small Molecule Libraries/chemistry/pharmacology
Tags: *drug discovery, *Ligands, 2017, Adenosine/metabolism, Animals, Atherosclerosis, Cardiac death, Cardiovascular Diseases/drug therapy/metabolism, Cardiovascular System/metabolism, Department of Integrative Medical Sciences, Geldenhuys Werner J, Hanif Ahmad, Humans, Hydrogen Bonding, Models, Molecular, Molecular Structure, Molecules (Basel, Switzerland), myocardial infarction, Nayeem Mohammed A, NEOMED College of Medicine, Protein Binding, Purinergic P1/*chemistry/*metabolism, Receptors, Signal Transduction, Structure-Activity Relationship, Vascular tone, Yun June
Misfolding of CasBrE SU is reversed by interactions with 4070A Env: implications for gammaretroviral neuropathogenesis.
Tags: 2010, Animals, Cell Line, Department of Integrative Medical Sciences, env/*metabolism, Experimental/*virology, Gene Products, Helper Viruses/metabolism/pathogenicity/*physiology, Leukemia, Leukemia Virus, Li Ying, Lynch William P, Mice, Motor Neuron Disease/*virology, Murine/metabolism/pathogenicity/*physiology, NEOMED College of Medicine, Neural Stem Cells/*virology, Protein Binding, Protein Folding, Protein Subunits/metabolism, Retroviridae Infections/*virology, Retrovirology, Tumor Virus Infections/*virology, Virulence
Tags: 2015, Adenosine Triphosphate/*analogs & derivatives/*chemistry, Amino Acid, Amino Acid Sequence, Animals, ATP, Catalysis, Cercopithecus aethiops, Chemical Biology, Chou Wen-Hai, COS Cells, Geldenhuys Werner J, Glutamine/chemistry, Han Xiqian, Humans, Inbred C57BL, Kumar Varun, Leucine/chemistry, Lysine/chemistry, Messing Robert O, Mice, Molecular Sequence Data, Neutrophils/metabolism, Phenylalanine/chemistry, Phosphorylation, Protein Binding, Protein Kinase C (PKC), Protein Kinase C-delta/*metabolism, Protein Phosphorylation, Purines/chemistry, Sequence Homology, Signal Transduction, stroke, Substrate Specificity, Superoxides/chemistry, The Journal of biological chemistry, Transgenic, Wang Dan, Weng Yi-Chinn
Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury.
Tags: 2016, Alcoholic/*pathology, Alcohols/*toxicity, Animals, Carboxylic Ester Hydrolases/*metabolism, Chemical and Drug Induced Liver Injury/*pathology, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diet/*adverse effects, Fatty Liver, Gene Expression Regulation, Genetic, Hepatocyte Nuclear Factor 4/*metabolism, Hepatocytes/metabolism, Humans, Inbred C57BL, Jadhav Kavita, Knockout, Li Yuanyuan, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Promoter Regions, Protein Binding, Scientific reports, Xu Jiesi, Xu Yang, Yin Liya, You Min, Zhang Yanqiao
Tags: 2003, Amino Acid Sequence, Animals, Bennett V J, CHO Cells, Cricetinae, Down-Regulation/*drug effects, Electrophysiology, Ligands, Neurokinin-1/*agonists/*metabolism, Peptides, Perrine S A, Potassium/metabolism, Protein Binding, Rana catesbeiana, Receptors, Simmons M A, Tachykinins/chemistry/*pharmacology
Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling.
Tags: 2009, Animals, Bryant Jennifer E, Cell Differentiation/*physiology, Collagen Type VI/*metabolism/physiology, Costic Donald J, Department of Integrative Medical Sciences, Doane Kathleen J, Dockry Michelle, Fibroblasts/*cytology, Immunoblotting, Integrin alpha3/*metabolism, Journal of molecular and cellular cardiology, Koshy John C, Luther Daniel J, Male, Meszaros J Gary, Mohile Monica V, Myocardial Infarction/*metabolism, Myocardium/*cytology, NEOMED College of Medicine, Olson Erik R, Protein Binding, Rats, Shamhart Patricia E
Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.
Tags: *ERK1/2, *Nrf2, *OSTEOARTHRITIS, *Redox, *Wogonin, 2017, Ansari Mohammad Y, Anti-Inflammatory Agents/administration & dosage, Chondrocytes/drug effects/pathology, Department of Anatomy & Neurobiology, Devarapalli Pratap, Flavanones/*administration & dosage, Free radical biology & medicine, Gene Expression Regulation/drug effects, Haqqi Tariq M, Haseeb Abdul, Haynie Sara, Humans, Inflammation/*drug therapy/metabolism/pathology, Kelch-Like ECH-Associated Protein 1/chemistry/*genetics/metabolism, Khan Nazir M, MAP Kinase Signaling System/drug effects, Molecular Docking Simulation, NEOMED College of Medicine, NF-E2-Related Factor 2/antagonists & inhibitors/chemistry/*genetics/metabolism, Osteoarthritis/*drug therapy/metabolism/pathology, Protein Binding, Reactive Oxygen Species/metabolism, Signal Transduction/drug effects
Tags: 2004, alpha-Macroglobulins/immunology/metabolism, Antigens, Carrier Proteins/immunology/metabolism/*physiology, CD/drug effects/immunology, Cell Proliferation/drug effects, Cellular immunology, Cytokines/*biosynthesis/drug effects, Female, Glycodelin, Glycoproteins/immunology/metabolism/*physiology, Humans, Interleukin-2/biosynthesis, Interleukin-4/biosynthesis, Kinetics, Kiyatkina Nadya, Koo Peter H, LEUKOCYTES, Low Density Lipoprotein Receptor-Related Protein-1, Lymphocyte Activation/immunology, Mononuclear/drug effects/immunology, Pregnancy, Pregnancy Proteins/immunology/metabolism/*physiology, Protein Binding, Skornicka Erin L, T-Lymphocytes/cytology/drug effects/*immunology, Time Factors, Tykocinski Mark L, Weber Matthew C
Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia.
Tags: *Acute lymphoblastic leukemia, *Cancer, *Co-culture model, *Lipids, *Lipoprotein lipase, *Metabolism, 2018, Amides/chemistry/metabolism/pharmacology, Antineoplastic Agents/*chemistry/metabolism/pharmacology, Binding Sites, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Coculture Techniques, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dyslipidemias/complications/metabolism/pathology, Geldenhuys Werner J, Gibson Laura F, Humans, Lipoprotein Lipase/antagonists & inhibitors/*metabolism, Mesenchymal Stem Cells/cytology/metabolism, Molecular Docking Simulation, Nair Rajesh R, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Piktel Debbie, Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications/metabolism/pathology, Protein Binding, Protein Structure, Sadana Prabodh, Serum Albumin/chemistry/metabolism, Tertiary, Tumor
Tags: *Bioenergetics, *Glitazones, *Mitochondria, *Small Molecule Libraries, *Type II diabetes, 2016, Bioorganic & medicinal chemistry letters, Darvesh Altaf S, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Hypoglycemic Agents/chemistry/metabolism, Leeper Thomas C, Ligands, Mitochondrial Proteins/*metabolism, Morris Daniel L, NEOMED College of Pharmacy, Protein Binding, Sullivan Patrick G, Thiazolidinediones/chemistry/metabolism, Yonutas Heather M
Tags: *Quantitative Structure-Activity Relationship, 2013, Amines/*chemistry/metabolism, Aza Compounds/chemistry, Binding Sites, Bioorganic & medicinal chemistry letters, Geldenhuys Werner J, Kinetics, Malan Sarel F, Molecular Docking Simulation, Novotny Nicholas, Protein Binding, Protein Structure, Receptors, sigma/*chemistry/metabolism, Tertiary, Van der Schyf Cornelis J
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease.
Tags: 2012, Al-Baghdadi Osamah B, Alkaloids/*chemistry/isolation & purification/pharmacology, Animals, Benzodioxoles/*chemistry/isolation & purification/pharmacology, Binding Sites, Bioorganic & medicinal chemistry letters, Blood-Brain Barrier/drug effects, Bovine/metabolism, Cattle, Geldenhuys Werner J, Humans, Hydrogen Bonding, Molecular Docking Simulation, Monoamine Oxidase Inhibitors/*chemistry/isolation & purification/pharmacology, Monoamine Oxidase/*chemistry/metabolism, Parkinson Disease/metabolism/pathology, Piper nigrum/*chemistry, Piperidines/*chemistry/isolation & purification/pharmacology, Polyunsaturated Alkamides/*chemistry/isolation & purification/pharmacology, Prater Natalie I, Protein Binding, Protein Structure, Serum Albumin, Tertiary, Van der Schyf Cornelis J
Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems.
Tags: 2009, Animals, Biochemical pharmacology, Bourque Melanie, Corpus Striatum/*metabolism, Di Paolo Therese, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/*genetics, Female, Ji Jing, Male, Messenger/biosynthesis, Mice, Mutant Strains, Protein Binding, Reserpine/pharmacology, RNA, Sex Characteristics, Substantia Nigra/*metabolism, Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
Pertubation of beta1 integrin function using anti-sense or function-blocking antibodies on corneal cells grown on fibronectin and tenascin.
Tags: 2002, Animals, Antisense/*pharmacology, Bhattacharya Raka, Cattle, Cell Adhesion, Cell biology international, Cell Culture Techniques/*methods, Cells, Chick Embryo, Chickens, Complementary/metabolism, Cornea/*cytology, Cultured, DNA, Doane Kathleen J, Dose-Response Relationship, Drug, Fibronectins/*metabolism, Fluorescence, Immunohistochemistry, Integrin beta1/*metabolism/*physiology, Integrins/metabolism, Marchant Jeff, Microscopy, Oligonucleotides, Protein Binding, Retroviridae/genetics, Tenascin/*metabolism
Binding of sequence-specific proteins to the 3'-untranslated region of vasoactive intestinal peptide mRNA.
Tags: 1995, Animals, Anterior/*metabolism, Base Sequence, Binding, Biochemical and biophysical research communications, Competitive, Cytoplasm/chemistry, Gene Expression Regulation, Genomic Library, Male, Messenger/*metabolism, Molecular Sequence Data, Pituitary Gland, Post-Transcriptional, Protein Binding, Proto-Oncogene Proteins c-fos/genetics, Rats, RNA, RNA Processing, RNA-Binding Proteins/*metabolism, RNA/metabolism, Signs S A, Sprague-Dawley, Subcellular Fractions, Tissue Distribution, Vasoactive Intestinal Peptide/*genetics, Wolford J K
Comparative binding of neurotrophins (NT-3, CNTF and NGF) and various cytokines to alpha 2-macroglobulin.
Tags: 1993, alpha-Macroglobulins/isolation & purification/*metabolism, Animals, Biochemical and biophysical research communications, Ciliary Neurotrophic Factor, Cytokines/isolation & purification/*metabolism, Electrophoresis, Humans, Koo P H, Liebl D J, Male, Mice, Nerve Growth Factors/isolation & purification/*metabolism, Nerve Tissue Proteins/isolation & purification/*metabolism, Polyacrylamide Gel, Protein Binding, Rats, Recombinant Proteins/isolation & purification/metabolism, Serotonin/metabolism, Submandibular Gland/metabolism
Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.
Tags: 1993, Afferent/drug effects/ultrastructure, alpha-Macroglobulins/metabolism/*pharmacology, Animals, Bovine/pharmacology, Cell Survival/drug effects, Cells, Chick Embryo, Cultured, Frontal Lobe/*cytology/embryology, Ganglia, Humans, Journal of neuroscience research, Koo P H, Liebl D J, Nerve Growth Factors/*antagonists & inhibitors/pharmacology, Neurites/drug effects/ultrastructure, Neurons, Neurons/*drug effects/ultrastructure, Protein Binding, Rats, Serotonin/metabolism/*pharmacology, Serum Albumin, Spinal/*cytology/embryology
Tags: *Cell Movement, 2016, Arosarena Oneida A, Barr Eric W, Bryant Evan, Carcinoma, Cell Adhesion, Cell Line, Cell Proliferation, Cell Survival, Dela Cadena Raul A, Denny Michael F, Department of Anatomy & Neurobiology, Enzyme Activation, Gene Expression Regulation, Head and Neck Neoplasms/genetics/*metabolism/pathology, Humans, Integrin beta1/metabolism, Journal of cellular physiology, Membrane Glycoproteins/genetics/*metabolism, Messenger/metabolism, Mitogen-Activated Protein Kinases/metabolism, Mouth Neoplasms/genetics/*metabolism/pathology, NEOMED College of Medicine, Neoplasm Invasiveness, Neoplastic, Protein Binding, RNA, RNA Interference, Safadi Fayez F, Signal Transduction, Squamous Cell Carcinoma of Head and Neck, Squamous Cell/genetics/*metabolism/pathology, Thorpe Ryan, Time Factors, Transfection, Tumor
Tags: 2014, 3T3 Cells, Abdelmagid Samir M, Actin Cytoskeleton/physiology, ADHESION, Alkaline Phosphatase/biosynthesis, Animals, Antibodies/immunology, Cell Adhesion, Cell Differentiation, Cell Line, Cell Proliferation, Chlorates/pharmacology, Department of Anatomy & Neurobiology, Extracellular Signal-Regulated MAP Kinases/biosynthesis, Eye Proteins/genetics/immunology/*metabolism, Focal Adhesion Kinase 1/biosynthesis, Focal Adhesions, Frara Nagat, Heparan Sulfate Proteoglycans/*metabolism, Heparin/pharmacology, Hisijara Israel Arango, Inbred C57BL, integrin, Journal of cellular biochemistry, Membrane Glycoproteins/genetics/immunology/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, OSTEOACTIVIN, OSTEOBLAST, OSTEOBLAST DIFFERENTIATION, Osteoblasts/*physiology, Osteogenesis/physiology, Protein Binding, Rats, Receptors, Recombinant Proteins, Safadi Fayez F, Scott Ethan M, Sondag Gregory R, Vitronectin/immunology/*metabolism