Browse Items · NEOMED Bibliography Database

Differential Effect Of Nimodipine In Attenuating Iron-induced Toxicity In Brain- And Blood-brain Barrier-associated Cell Types

Metal homeostasis is increasingly being evaluated as a therapeutic target in stroke and neurodegenerative diseases. Metal dysregulation has been shown to lead to protein aggregation, plaque formation and neuronal death. In 2007, we first reported…

Neurotrophin-3 Ameliorates Sensory-motor Deficits In Er81-deficient Mice

Two factors, the ETS transcription factor ER81 and skeletal muscle-derived neurotrophin-3 (NT3), are essential for the formation of muscle spindles and the function of spindle afferent-motoneuron synapses in the spinal cord. Spindles either…

Neurotrophin-3 And Trkc In Muscle Are Non-essential For The Development Of Mouse Muscle Spindles

NEUROTROPHIN-3 (NT3) or TrkC null mutant mice were examined for the presence of muscle spindles. Muscles of mastication, but not limbs, contained spindles in newborn and adolescent mutants. The intramuscular distribution and morphological properties…

Evolutionary Changes Of The Importance Of Olfaction In Cetaceans Based On The Olfactory Marker Protein Gene

Odontocetes and mysticetes are two extant suborders of cetaceans. It is reported that the former have no sense of olfaction, while the latter can smell in air. To explain the ecological reason why mysticetes still retain their sense of smell, two…

Tags: 2012, Aquatic adaptation, deletion causes, Echolocation, Eocene whale, Filter-feeder, gene, Genetics & Heredity, India, Journal Article or Conference Abstract Publication, Kishida T, marine mammals, Neurons, nucleotide, OMP, SEA, sequences, Thewissen J G M, WHALES

Laminar Pattern Of Synaptic Activity In Rat Primary Visual-cortex - Comparison Of In-vivo And In-vitro Studies Employing The Current Source Density Analysis

In the present study we employed current source density analysis to study the major excitatory/inhibitory pathways in rat primary visual cortex in vivo and in vitro. A natural photic stimulus was used in vivo and served as a baseline for…

Processing Of Communication Calls In Guinea Pig Auditory Cortex

Vocal communication is an important aspect of guinea pig behaviour and a large contributor to their acoustic environment. We postulated that some cortical areas have distinctive roles in processing conspecific calls. In order to test this hypothesis…

The Actions Of 3-aminopropanephosphinic Acid At Gaba(b) Receptors In Rat Hippocampus

The Invitro Hippocampal Slice Preparation As A Screen For Neurotoxicity

Tags: 1992, area ca1, Brain, Fountain S B, Long-Term Potentiation, Memory, metabolite, MPTP, Neurons, pyramidal cells-invitro, Synaptic Transmission, Teyler T J, Ting Y L T, Toxicology, Toxicology in Vitro, Trimethyltin

Kappa Agonist-induced Reduction In Dopamine Release - Site Of Action And Tolerance

Tags: 1992, Althaus J S, cortex, Donzanti B A, mu, Neurons, opiate, opioid receptors, Pathology, Payson M M, Pharmacology & Pharmacy, rat-brain, Research Communications in Chemical Pathology and Pharmacology, Vonvoigtlander P F

The Local Monoaminergic Dependency Of Spinal Ketamine

Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory

This experiment explores the role of two forms of long-term potentiation (LTP) in behavioral memory. NMDA and/or voltage-dependent calcium channels (VDCCs) were antagonized pharmacologically at levels that block nmdaLTP and vdccLTP, respectively, in…

Effect of Artificial Scotomas on Open-Loop Disparity Vergence Eye Movements

Purpose. To investigate the effect of an artificial scotoma on open-loop disparity vergence responses (DVRs) and vergence control mechanisms, we examined open-loop DVRs to disparity stimuli using monocular artificial scotomas in normal subjects.…

RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice

Evidence from human amyotrophic lateral sclerosis (ALS) patients and ALS-linked Cu/Zn superoxide dismutase (Cu/Zn-SOD) transgenic mice bearing the mutation of glycine to alanine at position 93 (G93A) suggests that the pro-apoptotic protein prostate…

Denervation of vagal cardiopulmonary receptors by injection of kainic acid into the nodose ganglia in dogs

We determined if kainic acid, a neuroexcitotoxin, could be used to denervate the cell bodies of cardiopulmonary vagal sensory neurons. Kainic acid (5 mug) was injected into the nodose ganglion of five dogs. Ten to fourteen days following this…

Tags: 2002, acetylstrophanthidin, afferents, Autonomic Neuroscience-Basic & Clinical, baroreflexes, cardiac receptors, cardiac vagal afferents, carotid-sinus, chemosensitive, Dunlap M E, Journal Article, Kainic Acid, nerve activity, Neurons, Neurosciences & Neurology, nodose ganglia, Stuesse S, Thames M D, Wallick D W

Frequency sensitivity range of the saccule to bone-conducted stimuli measured by vestibular evoked myogenic potentials

Vestibular evoked myogenic potentials (VEMPs) occurring in cervical muscles after intense sound stimulation conducted by air or bone are thought to be a polysynaptic response of otolith-vestibular nerve origin. We report the results of an experiment…

GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABA(A)R gamma(1) subunit during aging

Age-related hearing loss may result, in part, from declining levels of gamma-amino butyric acid (GABA) in the aging inferior colliculus (IC). An upregulation of the GABA(A)R gamma(1) subunit, which has been shown to increase sensitivity to GABA,…

Sharing of sensory terminals between the dynamic bag1 and static bag2 fibers in the rat muscle spindle.

The nuclear bag1 intrafusal fiber mediates the dynamic (velocity) sensitivity, whereas the nuclear bag2 and nuclear chain fibers mediate the static (length) sensitivity of muscle spindles to stretch. The pattern of branching of primary and secondary…

Tags: 1987, Afferent/*ultrastructure, Animals, Axons/ultrastructure, Brain research, Female, Inbred Strains, Kucera J, Muscle Spindles/*ultrastructure, Nerve Fibers/*ultrastructure, Neurons, Rats, Walro J M

Non-neural and neural expression of myosin heavy chains by regenerated intrafusal fibers of rats.

Expression of myosin heavy chain (MHC) isoforms was studied in rat soleus (SOL) and extensor digitorum longus (EDL) muscles which regenerated in the presence or absence of innervation. Frozen sections of two 5 day denervated SOL and EDL grafts, two…

Tags: *Muscle Denervation, *Nerve Regeneration, 1991, Afferent/*metabolism, Animals, Female, Inbred Strains, Kucera J, Motor Endplate/metabolism, Muscles/*metabolism/transplantation, Myosins/analysis/*biosynthesis, Narvy R, Neurons, Neuroscience letters, Organ Specificity, Rats, Walro J M

Innervation of regenerated spindles in muscle grafts of the rat.

Features of the nerve supply and the encapsulated fibers of muscle spindles were assessed in grafted and normal extensor digitorum longus (EDL) muscles of rats by analysis of serial 10-microns frozen transverse sections stained for enzymes which…

Estrogen receptor-alpha and -beta coexist in a subpopulation of sensory neurons of female rat dorsal root ganglia.

Immunoreactivities for estrogen receptor-alpha (ER-alpha) and ER-beta are expressed in sensory neurons of the dorsal root ganglia (DRG). It has not been established, however, if the two receptor subtypes coexist in the same neuron. Double-staining…

The re-expression of two myosin heavy chains in regenerated rat muscle spindles.

The vascular supply and tendons of the extensor digitorum longus (EDL) muscles of two adult rats were unilaterally severed and the muscles were allowed to regenerate for 40 days. Serial frozen sections of muscle grafts were cut and stained for…

Tags: *Gene Expression Regulation, *Regeneration, 1989, Afferent/*physiology, Animals, Fei C, Female, Immunohistochemistry, Inbred F344, Muscle Denervation, Muscles/innervation/*metabolism, Myosins/*metabolism, Neurons, Neuroscience letters, Rats, Walro J M

Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.

The acoustic rearing environment can alter central auditory coding properties, yet altered neural coding is seldom linked with specific deficits to adult perceptual skills. To test whether developmental hearing loss resulted in comparable changes to…

Tags: *Attention, *Behavior, 2012, Afferent/pathology, Animal, Animals, Conductive/pathology/*physiopathology, Department of Anatomy & Neurobiology, Female, Gerbillinae, Hearing Loss, Kelly Jack B, Male, NEOMED College of Medicine, Neurons, PloS one, Rosen Merri J, Sanes Dan H, Sarro Emma C

Enhanced cardiopulmonary reflex inhibition of heart rate during exercise.

We tested the hypothesis that the reflex inhibition of heart rate (HR) during mechanical (acute bolus injection of 0.5% and 2% of estimated blood volume) and chemical (phenylbiguanide, PBG, 2.5 and 5 micrograms.kg-1) stimulation of cardiopulmonary…

The role of sensory neurons in cervical ripening: effects of estrogen and neuropeptides.

Central nervous system nuclei and circuits, such as the medial preoptic, ventromedial and paraventricular nuclei of the hypothalamus, play important roles in reproduction and parturition, and are influenced by estrogen. Peripheral autonomic and…

Tags: 2004, Afferent/metabolism/*physiology, Cervical Ripening/*physiology, Cervix Uteri/innervation, Estrogen/physiology, Estrogens/*physiology, Female, Ganglia, Humans, Mowa C N, Neurons, Neuropeptides/biosynthesis/*physiology, Papka R E, Pregnancy, Receptors, Spinal/physiology, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Intracellular recordings from combination-sensitive neurons in the inferior colliculus.

In vertebrate auditory systems, specialized combination-sensitive neurons analyze complex vocal signals by integrating information across multiple frequency bands. We studied combination-sensitive interactions in neurons of the inferior colliculus…

Roles of inhibition in complex auditory responses in the inferior colliculus: inhibited combination-sensitive neurons.

We studied the functional properties and underlying neural mechanisms associated with inhibitory combination-sensitive neurons in the mustached bat's inferior colliculus (IC). In these neurons, the excitatory response to best frequency tones was…

Cardiac afferents attenuate the muscle metaboreflex in the rat.

The influence of cardiac afferents on the muscle metaboreflex was examined in 16 rats instrumented with a Silastic-tipped catheter in the pericardial space and right atrium, Doppler ultrasonic flow probe and a pneumatic vascular occluder around the…

Substance P in the uterine cervix, dorsal root ganglia and spinal cord during pregnancy and the effect of estrogen on SP synthesis.

Prior to parturition the non-pliable uterine cervix undergoes a ripening process ("softens" and dilates) to allow a timely passage of the fetus at term. The exact mechanism(s) triggering and involved in cervical ripening are unknown, though evidence…

Pathways from auditory cortex to the cochlear nucleus in guinea pigs.

The inferior colliculus (IC) and superior olivary complex (SOC) are important sources of descending pathways to the cochlear nucleus. The IC and SOC are also targets of direct projections from the auditory cortex but it is not known if cortical axons…

Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus.

Conditioning stimulation of afferent fibers in hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of responses evoked by stimulation of an independent set of afferent fibers. PTD was present within 5 s of conditioning…

Presynaptic mechanism for heterosynaptic, posttetanic depression in area CA1 of rat hippocampus.

Conditioning stimulation applied to afferent fibers in stratum radiatum or stratum oriens of hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of excitatory postsynaptic potentials (EPSPs). PTD amounted to a

Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.

Methylamine-modified alpha-2-macroglobulin (MA-alpha 2M) has been recently shown to inhibit the biological activity of beta-nerve growth factor (NGF) in promoting neurite outgrowth by embryonic dorsal root ganglia in culture (Koo PH, Liebl DJ, J…

Browse Items (35 total)