Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory

Title

Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory

Creator

Borroni A M; Fichtenholtz H; Woodside B L; Teyler T J

Publisher

Journal of Neuroscience

Date

2000
2000-12

Description

This experiment explores the role of two forms of long-term potentiation (LTP) in behavioral memory. NMDA and/or voltage-dependent calcium channels (VDCCs) were antagonized pharmacologically at levels that block nmdaLTP and vdccLTP, respectively, in rats learning an eight-arm radial maze task. Animals were trained twice a day for 11 d under the systemic influence of MK-801, verapamil, both drugs, or saline. During acquisition, the mixed drug group displayed significantly more working memory errors and reference memory errors than all other groups. The mixed drug group was markedly impaired on the first daily trial but improved dramatically on their second daily trial. After a 7 d delay, saline and MK-801 animals maintained their predelay level of performance. The performance of the verapamil groups declined significantly over the delay. These results demonstrate that: (1) vdccLTP is necessary for the retention of information over a 7 dperiod, (2) the blockade of both forms of LTP prevents the retention of information over a 21 hr period, and (3) blockade of both forms of LTP does not prevent the storing of information over a short period of time (3 hr).

Subject

hippocampus; rat; learning; verapamil; Neurosciences & Neurology; expression; neurons; long-term potentiation; environment; NMDA; MK-801; 2 forms; voltage-dependent calcium channel; nmdaLTP; spatial memory; vdccLTP; antagonist mk-801; working

Identifier

n/a

Format

Journal Article or Conference Abstract Publication

URL Address

n/a

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

9272-9276

Issue

24

Volume

20

Citation

Borroni A M; Fichtenholtz H; Woodside B L; Teyler T J, “Role of voltage-dependent calcium channel long-term potentiation (LTP) and NMDA LTP in spatial memory,” NEOMED Bibliography Database, accessed April 16, 2021, https://neomed.omeka.net/items/show/8678.

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