Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.

Title

Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.

Creator

Rosen Merri J; Sarro Emma C; Kelly Jack B; Sanes Dan H

Publisher

PloS one

Date

2012
1905-7

Description

The acoustic rearing environment can alter central auditory coding properties, yet altered neural coding is seldom linked with specific deficits to adult perceptual skills. To test whether developmental hearing loss resulted in comparable changes to perception and sensory coding, we examined behavioral and neural detection thresholds for sinusoidally amplitude modulated (sAM) stimuli. Behavioral sAM detection thresholds for slow (5 Hz) modulations were significantly worse for animals reared with bilateral conductive hearing loss (CHL), as compared to controls. This difference could not be attributed to hearing thresholds, proficiency at the task, or proxies for attention. Detection thresholds across the groups did not differ for fast (100 Hz) modulations, a result paralleling that seen in humans. Neural responses to sAM stimuli were recorded in single auditory cortex neurons from separate groups of awake animals. Neurometric analyses indicated equivalent thresholds for the most sensitive neurons, but a significantly poorer detection threshold for slow modulations across the population of CHL neurons as compared to controls. The magnitude of the neural deficit matched that of the behavioral differences, suggesting that a reduction of sensory information can account for limitations to perceptual skills.

Subject

Female; Male; Animals; Gerbillinae; *Attention; *Behavior; Neurons; Animal; Hearing Loss; Afferent/pathology; Conductive/pathology/*physiopathology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

e41514–e41514

Issue

7

Volume

7

Citation

Rosen Merri J; Sarro Emma C; Kelly Jack B; Sanes Dan H, “Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.,” NEOMED Bibliography Database, accessed September 17, 2021, https://neomed.omeka.net/items/show/4942.

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