Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.

Serotonin-activated alpha 2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons.

Liebl D J; Koo P H

Journal of neuroscience research

1993

1993-06

Methylamine-modified alpha-2-macroglobulin (MA-alpha 2M) has been recently shown to inhibit the biological activity of beta-nerve growth factor (NGF) in promoting neurite outgrowth by embryonic dorsal root ganglia in culture (Koo PH, Liebl DJ, J Neurosci Res 31:678-692, 1992). The objectives of this study are to determine whether alpha 2M can also be modified by larger aromatic biogenic amines such as

Afferent/drug effects/ultrastructure; alpha-Macroglobulins/metabolism/*pharmacology; Animals; Bovine/pharmacology; Cell Survival/drug effects; Cells; Chick Embryo; Cultured; Frontal Lobe/*cytology/embryology; Ganglia; Humans; Nerve Growth Factors/*antagonists & inhibitors/pharmacology; Neurites/drug effects/ultrastructure; Neurons; Neurons/*drug effects/ultrastructure; Protein Binding; Rats; Serotonin/metabolism/*pharmacology; Serum Albumin; Spinal/*cytology/embryology

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