Browse Items · NEOMED Bibliography Database

Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease

Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic…

Tags: 2021, Alzheimer’s disease, Alzheimer&#8217, Casali BT, Cells, Department of Pharmaceutical Sciences, Inflammation, journalArticle, May 2021 List, Microglia, NEOMED College of Pharmacy, NEOMED College of Pharmacy Postdoc, NEOMED Postdoc Publications, Neurodegenerative Diseases, Neuroinflammation, Reed-Geaghan EG, s disease, TREM2

Differential Effect Of Nimodipine In Attenuating Iron-induced Toxicity In Brain- And Blood-brain Barrier-associated Cell Types

Metal homeostasis is increasingly being evaluated as a therapeutic target in stroke and neurodegenerative diseases. Metal dysregulation has been shown to lead to protein aggregation, plaque formation and neuronal death. In 2007, we first reported…

Inhibition Of Phosphorylation Of Trkb And Trkc And Their Signal Transduction By Alpha(2)-macroglobulin

Monoamine-activated alpha(2)-macroglobulin (alpha(2)M) was shown to reduce the dopamine concentration in corpus striatum of adult rat brains and inhibit other neuronal functions in vivo and in vitro. As brain-derived neurotrophic factor,…

Chronic exposure to a glyphosate-containing pesticide leads to mitochondrial dysfunction and increased reactive oxygen species production in Caenorhabditis elegans

Glyphosate-containing herbicides are among the most widely-used in the world. Although glyphosate itself is relatively non-toxic, growing evidence suggests that commercial herbicide formulations may lead to increased oxidative stress and…

Why should we use multifunctional neuroprotective and neurorestorative drugs for Parkinson's disease?

Parkinson's disease (PD) is a severe neurodegenerative disorder, with no available drugs able to prevent the neuronal cell loss characteristic in brains of patients suffering from PD. Due to the complex cascade of molecular events involved in the…

Magic bullets or novel multimodal drugs with various CNS targets for Parkinson's disease?

Tags: 2007, Biotechnology & Applied Microbiology, disorders, iron, Journal Article, monoamine-oxidase inhibition, Nature Reviews Drug Discovery, Neurodegenerative Diseases, neurorescue, Pharmacology & Pharmacy, rasagiline, Van der Schyf C J, Youdim M B H

Multifunctional drugs with different CNS targets for neuropsychiatric disorders

The multiple disease etiologies that lead to neuropsychiatric disorders, such as Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis, Huntington disease, schizophrenia, depressive illness and stroke, offer significant challenges to…

Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.

Reduced bone mineral density (BMD) and its clinical sequelae, osteoporosis, occur at a much greater rate in patients with Alzheimer's disease (AD), often emerging early in the disease before significant cognitive decline is seen. Reduced BMD…

Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N

Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.

BACKGROUND: Fractalkine (CX3CL1) and its receptor (CX3CR1) play an important role in regulating microglial function. We have previously shown that Cx3cr1 deficiency exacerbated tau pathology and led to cognitive impairment. However, it is still…

Tags: 2018, Alzheimer's disease, Animal, Animals, Antigens, Bemiller Shane M, Bhaskar Kiran, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cannon Judy L, Cardona Astrid E, Cells – Drug Effects, Cells – Metabolism, Cells – Pathology, Chemokine CX3CL1/*genetics/metabolism, Cognition Disorders – Etiology, Cognition Disorders/etiology, Crish Samuel D, CX3CL1, CX3CR1, Cytokines, Cytokines – Metabolism, Cytokines/metabolism, Department of Pharmaceutical Sciences, Differentiation/genetics/metabolism, Disease Models, Formica Shane V, Gene Expression Regulation/drug effects/*genetics, Genes, Genes – Drug Effects, Journal of neuroinflammation, Jung Steffen, Kim Ki-Wook, Kokiko-Cochran Olga N, Lamb Bruce T, Learning, Lipopolysaccharides, Lipopolysaccharides/toxicity, Maphis Nicole M, Maze Learning, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia, Microglia/drug effects/*metabolism/pathology, Miller Crystal M, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurodegenerative Diseases – Pathology, Neuroinflammation, Surface, Surface – Metabolism, Tau, tau Proteins/genetics/metabolism, Tauopathies, Tauopathies/complications/genetics/*pathology, Transgenic, Wilson Gina N, Xu Guixiang

Browse Items (9 total)