Browse Items (29 total)
- Tags: Transgenic
Tags: *Axonopathy, *axons, *neurodegeneration, *neurofilament, *node of Ranvier, *superior colliculus, 2018, Action Potentials, Animals, Axons/pathology, Crish S D, Cytoskeleton/pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Female, Glaucoma/metabolism/pathology/*physiopathology, Inbred C57BL, Male, Meier J, Mice, NEOMED College of Pharmacy, Neuroscience, Optic Nerve/metabolism/pathology, Plyler E S, Ranvier's Nodes/*physiology/ultrastructure, Smith M A, Transgenic, Visual Pathways/metabolism/*physiopathology/ultrastructure, Voltage-Gated Sodium Channels/metabolism
Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.
Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N
Tags: 2005, Animal, Animals, Askew Michael J, Biomechanical Phenomena, Body Weight/drug effects, Bone and Bones/drug effects, Bone/prevention & control, Collagen Type I, Collagen/genetics, Densitometry, Department of Family & Community Medicine, Disease Models, Femur/drug effects/pathology, Fractures, Growth Hormone/*therapeutic use, Heterozygote, Humans, Inbred C57BL, Jarjoura David, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, King Donna, Lumbar Vertebrae/drug effects, McEwen Heather A, Mice, Mutation, NEOMED College of Medicine, Osteoblasts/*drug effects/metabolism, Osteogenesis Imperfecta/*drug therapy, Phenotype, Time Factors, Transgenic
Cholesteryl ester transfer protein alters liver and plasma triglyceride metabolism through two liver networks in female mice.
Tags: *estrogen, *estrogen receptor alpha, *lipid and lipoprotein metabolism, *small heterodimer partner, *triglycerides, *very low density lipoprotein, 2016, Animals, Cholesterol Ester Transfer Proteins/*physiology, Department of Integrative Medical Sciences, Estrogen Receptor alpha/metabolism, Estrogens/physiology, Female, Inbred C57BL, Journal of lipid research, Le Thao D, Lee Yoon-Kwang, Lipid Metabolism, Liver/*metabolism, Metabolic Networks and Pathways, Mice, NEOMED College of Medicine, Oxidation-Reduction, Palmisano Brian T, Stafford John M, Transgenic, Triglycerides/biosynthesis/*blood, Zhu Lin
Tags: *Aldehyde Reductase/genetics/metabolism, 2011, Adenoviridae, Animal, Animals, Blood Glucose/*metabolism, Chiang John Y L, Cholesterol/analysis, Cytoplasmic and Nuclear/genetics/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism/physiopathology, Disease Models, Fatty Liver/genetics/*metabolism/physiopathology, Ge Xuemei, Gene Expression, Genetic Vectors, Gluconeogenesis/genetics, Homeostasis, Humans, Journal of lipid research, Li Tiangang, Liver/*metabolism/physiopathology, Ma Huiyan, Malondialdehyde/blood, Mice, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, Transfection, Transgenic, Triglycerides/analysis, Yin Liya, Zhang Yanqiao
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.
Tags: *Alzheimers disease, *Immunity, *Inflammation, *Tauopathy, *TREM2, 2017, Allan Kevin, Animal, Animals, Bemiller Shane M, Crish Samuel D, Department of Pharmaceutical Sciences, Disease Models, Formica Shane V, Humans, Immunologic/*deficiency, Inbred C57BL, Kokiko-Cochran Olga N, Lamb Bruce T, Landreth Gary E, Lasagna-Reeves Cristian A, McCray Tyler J, Membrane Glycoproteins/*deficiency, Mice, Microglia/metabolism, Molecular neurodegeneration, NEOMED College of Pharmacy, Protein Kinases/*metabolism, Ransohoff Richard M, Receptors, Signal Transduction/physiology, tau Proteins/*metabolism, Tauopathies/metabolism/*pathology, Transgenic, Wilson Gina, Xu Guixiang
Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma.
Tags: 2018, AMP-activated protein kinase, AMP-Activated Protein Kinases/*metabolism, Animal, Animals, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cells – Drug Effects, Cells – Pathology, Department of Pharmaceutical Sciences, Diet, Disease Models, Eye Proteins/genetics, Female, G-Protein-Coupled – Metabolism, G-Protein-Coupled/*metabolism, Glaucoma, Glaucoma – Complications, Glaucoma – Pathology, Glaucoma/*complications/pathology, Harun-Or-Rashid Mohammad, Impact of Events Scale, Inbred DBA, Inflammation – Etiology, Inflammation – Prevention and Control, Inflammation hydroxycarboxylic acid receptor, Inflammation/*etiology/*prevention & control, Inman Denise M, Journal of neuroinflammation, Ketogenic diet, Ketogenic/methods, Male, Membrane Glycoproteins, Membrane Glycoproteins/genetics, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia/drug effects/pathology, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Neuroprotection/drug effects/*physiology, NLR Family, Optic Nerve – Pathology, Optic Nerve/pathology, Phosphotransferases – Metabolism, Proteins, Pyrin Domain-Containing 3 Protein/genetics/metabolism, Receptors, Retina – Drug Effects, Retina – Pathology, Retinal Ganglion Cells/drug effects/*pathology, Transgenic
Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy.
Tags: 2018, Alzheimer's disease, Animal, Animals, Antigens, Bemiller Shane M, Bhaskar Kiran, Biological, Calcium Binding Proteins – Metabolism, Calcium-Binding Proteins/metabolism, Cannon Judy L, Cardona Astrid E, Cells – Drug Effects, Cells – Metabolism, Cells – Pathology, Chemokine CX3CL1/*genetics/metabolism, Cognition Disorders – Etiology, Cognition Disorders/etiology, Crish Samuel D, CX3CL1, CX3CR1, Cytokines, Cytokines – Metabolism, Cytokines/metabolism, Department of Pharmaceutical Sciences, Differentiation/genetics/metabolism, Disease Models, Formica Shane V, Gene Expression Regulation/drug effects/*genetics, Genes, Genes – Drug Effects, Journal of neuroinflammation, Jung Steffen, Kim Ki-Wook, Kokiko-Cochran Olga N, Lamb Bruce T, Learning, Lipopolysaccharides, Lipopolysaccharides/toxicity, Maphis Nicole M, Maze Learning, Mice, Microfilament Proteins – Metabolism, Microfilament Proteins/metabolism, Microglia, Microglia/drug effects/*metabolism/pathology, Miller Crystal M, Models, Mutation, Mutation/genetics, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurodegenerative Diseases – Pathology, Neuroinflammation, Surface, Surface – Metabolism, Tau, tau Proteins/genetics/metabolism, Tauopathies, Tauopathies/complications/genetics/*pathology, Transgenic, Wilson Gina N, Xu Guixiang
Tags: 129 Strain, 2015, Animals, Bardakjian Raffi, Bratz Ian, Cardiac function, Chilian William M, Circulation research, contrast echocardiography, Coronary Circulation/*physiology, Coronary Vessels/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Enrick Molly, Fu Frances Kwan, Graham Jacqueline, Hakobyan Tatevik, Hou Huagang, Hydrogen peroxide, Inbred C57BL, ion channel, Janota Danielle, Khan Nadeem, Kmetz John, Knockout, Kolz Christopher, Kuppusamy Periannan, Kv1.5 Potassium Channel/*physiology, Lindner Jonathan R, Logan Suzanna, Luli Jordan, Mice, Muscle, Nagane Masaki, NEOMED College of Medicine, NEOMED College of Pharmacy, Ohanyan Vahagn, Oyewumi Moses O, Smooth, Transgenic, Transgenic mice, Vascular/*metabolism, vasodilation, Vasodilation/*physiology, voltage-gated potassium channels, Yin Liya
Ecotropic Murine Leukemia Virus Infection of Glial Progenitors Interferes with Oligodendrocyte Differentiation: Implications for Neurovirulence.
Tags: 2016, 3T3 Cells, Animals, Cardona Sandra M, Cell Line, Cell Proliferation, Cell Survival, Department of Integrative Medical Sciences, Dunphy Jaclyn M, env/biosynthesis, Female, Gene Products, Journal of virology, Leukemia Virus, Li Ying, Lynch Connor R, Lynch William P, Macklin Wendy B, Male, Mice, Motor Neuron Disease/*virology, Murine/*pathogenicity, NEOMED College of Medicine, Neural Stem Cells/*virology, Neurogenesis/*physiology, Neuroglia/*virology, Oligodendroglia/cytology/virology, Pedraza Carlos E, Retroviridae Infections/*complications, Transgenic
Farnesoid X Receptor Agonist Represses Cytochrome P450 2D6 Expression by Upregulating Small Heterodimer Partner.
Tags: 2015, Animals, Cytochrome P-450 CYP2D6/*biosynthesis, Cytochrome P-450 Enzyme Inhibitors/*pharmacology, Cytoplasmic and Nuclear/*agonists, Department of Integrative Medical Sciences, Drug metabolism and disposition: the biological fate of chemicals, Enzymologic/drug effects, Gene Expression Regulation, Genetic/drug effects/genetics, HEK293 Cells, Hepatocytes/drug effects/enzymology/metabolism, Humans, Isoxazoles/*pharmacology, Jeong Hyunyoung, Knockout, Lee Yoon-Kwang, Mice, NEOMED College of Medicine, Pan Xian, Receptors, Transcription, Transgenic
Effects of growth hormone transgene expression on vertebrae in a mouse model of osteogenesis imperfecta.
Tags: 2005, Animal, Animals, Beamer Wesley G, Biomechanical Phenomena, Bone Density, Chase Jeff, Department of Family & Community Medicine, Disease Models, Female, Gene Expression, Genetic Therapy/*methods, Havey Robert M, Heterozygote, Human Growth Hormone/*genetics, Humans, Inbred C57BL, King Donna, Male, McEwen Heather A, Mice, NEOMED College of Medicine, Osteogenesis Imperfecta/pathology/physiopathology/*therapy, Patwardhan Avinash G, Sartori Mark, Spine, Spine/pathology/*physiology, Tail, Transgenic, Voronov Leonard
Altered Neuroinflammation and Behavior after Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease.
Tags: 2016, Alzheimer Disease/etiology/*metabolism/pathology, Alzheimer's disease, Amyloid beta-Peptides/*metabolism, Animal, Animal/physiology, Animals, Behavior, Bemiller Shane M, Bhaskar Kiran, Blotting, Brain Injuries, Brain/*metabolism/pathology, Crish Samuel, Department of Pharmaceutical Sciences, Disease Models, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunohistochemistry, Inbred C57BL, Inflammation/*metabolism/pathology, Journal of neurotrauma, Kokiko-Cochran Olga N, Lamb Bruce T, Lee Sungho, Lee Yu-Shang, macrophage, Mice, NEOMED College of Pharmacy, Neuroinflammation, Ransohoff Lena, Ransohoff Richard M, Saber Maha, Sikora Matt, Teknipp Ryan, Transgenic, Traumatic brain injury, Traumatic/complications/*metabolism/*pathology, Veenstra Mike, Western, Wilson Gina, Xu Guixiang
Alterations in the mechanical properties and composition of skin in human growth hormone transgenic mice.
Tags: *Biomechanical Phenomena, *Skin Physiological Phenomena, 2007, Animals, Connective tissue research, Elasticity, Female, Human Growth Hormone/*genetics, Humans, King Donna, Male, Mechanical, Mice, Serrat Maria A, Sex Characteristics, Skin/anatomy & histology/*chemistry, Stress, Transgenic, Vinyard Christopher J
Tags: 2015, Adenosine Triphosphate/*analogs & derivatives/*chemistry, Amino Acid, Amino Acid Sequence, Animals, ATP, Catalysis, Cercopithecus aethiops, Chemical Biology, Chou Wen-Hai, COS Cells, Geldenhuys Werner J, Glutamine/chemistry, Han Xiqian, Humans, Inbred C57BL, Kumar Varun, Leucine/chemistry, Lysine/chemistry, Messing Robert O, Mice, Molecular Sequence Data, Neutrophils/metabolism, Phenylalanine/chemistry, Phosphorylation, Protein Binding, Protein Kinase C (PKC), Protein Kinase C-delta/*metabolism, Protein Phosphorylation, Purines/chemistry, Sequence Homology, Signal Transduction, stroke, Substrate Specificity, Superoxides/chemistry, The Journal of biological chemistry, Transgenic, Wang Dan, Weng Yi-Chinn
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.
Tags: *Gene Expression Regulation, 2012, Animals, Bile Acids and Salts/*biosynthesis, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus, Dietary Fats/administration & dosage/adverse effects, Enzymologic, Epigenesis, Erickson Sandra K, Experimental/genetics/*metabolism, Fasting/metabolism, Francl Jessica M, Genetic/genetics, Glucose/*metabolism/pharmacology, Insulin/*metabolism, Klaassen Curtis D, Li Tiangang, Mice, NEOMED College of Medicine, Obesity/etiology/genetics/*metabolism, Ochoa Adrian, Postprandial Period/genetics, Receptors, Sweetening Agents/pharmacology, The Journal of biological chemistry, Transgenic, Zhang Youcai
Tags: *Muscle Development, 1999, Afferent Pathways/physiology, Aging/metabolism, Animals, Cell Lineage, Developmental, Fetal Proteins/metabolism, Gene Expression Regulation, Knockout, Kucera J, Mammals/anatomy & histology/*metabolism, Mice, Morphogenesis, Muscle, Muscle Contraction, Muscle Fibers, Muscle Proteins/deficiency/physiology, Muscle Spindles/physiology, Myosin Heavy Chains/*metabolism, Nerve Tissue Proteins/deficiency/physiology, Protein Isoforms/*metabolism, Rats, Skeletal/*chemistry/classification, Skeletal/chemistry/embryology/*growth & development/ultrastructure, Transgenic, Trends in neurosciences, Walro J M
Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation.
Tags: 2015, Adenosine Triphosphate/biosynthesis, Animals, Arterial Pressure/drug effects, Bioenergetics, Blood Flow Velocity/drug effects, Cardiac function, Cardiac/drug effects/*enzymology, Catalase/pharmacology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Integrative Medical Sciences, Echocardiography, Female, Gene Expression, Heart/drug effects/*enzymology, Hydrogen Peroxide/*metabolism/pharmacology, Injections, Intravenous, Journal of molecular and cellular cardiology, Kang Patrick T, Luther Daniel J, Male, Meszaros J Gary, Metabolic dilation, Mice, Mitochondria, Myocardium/*enzymology, Myocytes, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Ohanyan Vahagn, Oxidation-Reduction, Oxygen Consumption/drug effects, Redox regulation, Signal Transduction, Stroke Volume/drug effects, Superoxide dismutase 2 (SOD2), Superoxide Dismutase/*genetics/metabolism, Transgenic, Transgenic mice, Vasodilation/*drug effects
The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice.
Tags: 2004, Animals, Brain-Derived Neurotrophic Factor/deficiency/genetics/*metabolism, Central Nervous System Stimulants/poisoning, Corpus Striatum/*drug effects/*metabolism, Dluzen Dean E, Dopamine/*metabolism, Dose-Response Relationship, Drug, Female, Humans, Male, Methamphetamine/*poisoning, Mice, Mutation, Neuroscience letters, Neurotoxicity Syndromes/*etiology/*metabolism, Sex Factors, Structure-Activity Relationship, Substantia Nigra/drug effects/metabolism, Transgenic
Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.
Tags: 2016, Al-Azzam Nosayba, Animals, Boyce Joshua A, c-fos, Capillary Permeability, Cell Line, CysLT(1)R, Department of Integrative Medical Sciences, Dinoprostone/*immunology, Duah Ernest, E-prostanoid receptor 3, Edema/immunology, EP3 Subtype/*immunology, extracellular signal-regulated kinase, Humans, Inbred BALB C, Inbred C57BL, Inflammation/immunology, Kondeti Vinay, leukotriene D(4), Leukotriene D4/*immunology, Leukotriene/*immunology, macrophage inflammatory protein 1beta, Mast cells, Mast Cells/*immunology, Mice, NEOMED College of Medicine, Paruchuri Sailaja, prostaglandin D(2), Prostaglandin E, prostaglandin E(2), protein kinase G, Receptors, The Journal of allergy and clinical immunology, Thodeti Charles K, Transgenic, Tumor
Differential protein acetylation assists import of excess SOD2 into mitochondria and mediates SOD2 aggregation associated with cardiac hypertrophy in the murine
Tags: *Cardiac-specific transgenic mouse, *Mitochondria, *Mitochondrial translocation, *Protein acetylation, *Protein aggregation, *SOD2, 2017, Acetylation, Animals, Cardiomegaly/*metabolism, Chen Chwen-Lih, Chen Yeong-Renn, Cytosol/*metabolism, Department of Integrative Medical Sciences, Free radical biology & medicine, Heart/*physiology, Jin Zhicheng, Kang Patrick T, Mice, Mitochondria/*metabolism, NEOMED College of Medicine, Pathological, Post-Translational, Protein Aggregation, Protein Folding, Protein Processing, Protein Transport, Reactive Oxygen Species/metabolism, Sirtuin 3/metabolism, Superoxide Dismutase/genetics/*metabolism, Transgenic, Zhang Liwen
BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.
Tags: 2014, Alkylating/*adverse effects/pharmacology, Animals, Antineoplastic Agents, Biochemical pharmacology, Cardiotoxins/adverse effects/pharmacology, Carmustine/*adverse effects/pharmacology, Cattle, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Fatty Acids, Glutathione reductase, Glutathione Reductase/*antagonists & inhibitors/metabolism, Glutathione/*metabolism, Guarini Giacinta, Heart Ventricles/drug effects/metabolism/physiopathology, Heart/*drug effects/metabolism, Ion Channels/metabolism, Kang Patrick T, Left/*chemically induced/metabolism/physiopathology, Male, Mice, Mitochondria, Mitochondrial Proteins/metabolism, NEOMED College of Medicine, Nonesterified/metabolism, Oxidative Stress, Oxidative Stress/drug effects, Post-Translational/drug effects, Protein Processing, Rats, Ren Pei, S-Glutathionylation, Sprague-Dawley, Superoxide Dismutase/genetics/metabolism, Systolic dysfunction, Transgenic, Uncoupling Protein 3, Ventricular Dysfunction
Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.
Tags: *Alpha-synuclein, *ATP13A2, *Mice, *Phenotype, *Sensorimotor, 2018, Adenosine Triphosphatases/*deficiency/genetics, alpha-Synuclein/genetics/*metabolism, Animal, Animals, Behavioural brain research, Blackwood Rachel, Body Temperature, Body Weight, Department of Pharmaceutical Sciences, Dirr Emily R, Disease Models, Ekhator Osunde R, Female, Fleming Sheila M, Gait Disorders, Holden John G, Humans, Inbred C57BL, Male, Masliah Eliezer, Membrane Proteins/*deficiency/genetics, Mice, Motor Skills/physiology, NEOMED College of Pharmacy, Neurologic/*metabolism, Phenotype, Schultheis Patrick J, Severity of Illness Index, Sex Characteristics, Transgenic
Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.
Tags: 2015, Animals, Bile acid metabolism, Bile Acids and Salts/genetics/*metabolism, Biochimica et biophysica acta, Cheng Jie, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/metabolism, CYP7A1, Department of Integrative Medical Sciences, Diabetes Mellitus/genetics/*metabolism, Diet, farnesoid X receptor (FXR), Female, Ferrell Jessica M, Glucose/genetics/metabolism, Gonzalez Frank J, High-Fat/methods, Homeostasis, Inbred C57BL, Insulin Resistance, Intestinal Mucosa/metabolism, Jiang Changtao, Krausz Kristopher W, Li Tiangang, Lipid Metabolism/*physiology, lipidomics, Liver/metabolism, Male, Metabolome/*genetics, Metabolomics/methods, Mice, NEOMED College of Medicine, Obesity/genetics/*metabolism, Qi Yunpeng, Rats, Signal Transduction, tauro-beta-muricholic acid, Taurocholic Acid/analogs & derivatives/genetics/metabolism, Transgenic
Tags: *Genes, *Herpesvirus 1, *Immunocompromised Host, 1998, 3T3 Cells, Aging, Animals, Antibodies, Antibody Formation, Cellular, Cercopithecus aethiops, Docherty J J, Female, Herpes Simplex/*immunology, HIV/pathogenicity, Human, Humans, Immunity, Immunoglobulin G/blood, Journal of biomedical science, Kestler H W, Kinetics, Larsen N B, Male, Mice, nef, Simian Immunodeficiency Virus/*genetics/pathogenicity, Transgenic, Vero Cells, Viral/biosynthesis/blood
Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.
Tags: 2016, Abdelmagid Samir M, Animals, Barbe Mary F, Bone and Bones/*metabolism, Bone Density/physiology, Bone Remodeling/genetics/*physiology, Bone Resorption/metabolism, Cell Differentiation/genetics/*physiology, Department of Anatomy & Neurobiology, Eye Proteins/genetics/*metabolism, Frara Nagat, Journal of cellular physiology, Membrane Glycoproteins/genetics/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, Osteoblasts/*cytology, Osteoclasts/*cytology, Osteogenesis/genetics, Owen Thomas A, Popoff Steven N, Protein-Serine-Threonine Kinases/metabolism, Receptor, Receptors, Safadi Fayez F, Sondag Gregory R, Transforming Growth Factor beta/metabolism, Transforming Growth Factor-beta Type I, Transgenic, Yingling Vanessa R
Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization.
Tags: *Cell Movement, 2012, AbouAlaiwi Wissam A, Actin Cytoskeleton/*metabolism, Adapala Ravi K, Animals, Blotting, Bursley Chris, Capillary Permeability/*physiology, Cell Adhesion, Cilia/metabolism, Department of Integrative Medical Sciences, Endothelial Cells/cytology/*metabolism, Fluorescent Antibody Technique, Focal Adhesions/metabolism, Geldenhuys Werner J, HSP27 Heat-Shock Proteins/*metabolism, Jones Thomas J, Journal of cellular physiology, Mice, Nauli Surya M, NEOMED College of Medicine, Polycystic Kidney Diseases/physiopathology, Signal Transduction/physiology, Thodeti Charles K, Transgenic, Western
Regulation of cholesterol and bile acid homeostasis by the cholesterol 7alpha-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice.
Tags: 2013, Acetyl Coenzyme A/metabolism, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Francl Jessica M, Hepatology (Baltimore, Md.), Homeostasis/*physiology, Knockout, Li Tiangang, Lipid Metabolism/physiology, Liver/metabolism, Male, Messenger/metabolism, Mice, MicroRNAs/*metabolism, Models, NEOMED College of Medicine, RNA, Signal Transduction/*physiology, Sterol Regulatory Element Binding Protein 2/*metabolism, Transgenic
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice.
Tags: *Insulin Resistance, 2010, Animals, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Department of Integrative Medical Sciences, Dietary Fats/*administration & dosage, Hepatology (Baltimore, Md.), Homeostasis, Hsu Peter, Li Tiangang, Lipid Metabolism, Lipoproteins, Liver/*metabolism, Matozel Michelle, Mice, NEOMED College of Medicine, Novak Colleen M, Obesity/*metabolism, Owsley Erika, Transgenic, VLDL/metabolism