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Tags: NG-Nitroarginine Methyl Ester/pharmacology

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Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.

We have previously shown transient receptor potential vanilloid subtype 1 (TRPV1) channel-dependent coronary function is compromised in pigs with metabolic syndrome (MetS). However, the mechanisms through which TRPV1 channels couple coronary blood…

Tags: 13-dienoic Acid/pharmacology, 15-Hydroxy-11 alpha, 2012, 9 alpha-(epoxymethano)prosta-5, American journal of physiology. Heart and circulatory physiology, Anilides/pharmacology, Animals, Bratz Ian N, Capsaicin/analogs & derivatives/pharmacology, Cinnamates/pharmacology, Coronary Vessels/drug effects/*metabolism/physiopathology, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Cardiomyopathies/drug therapy/*metabolism, Enzyme Inhibitors/pharmacology, Guarini Giacinta, Inbred C57BL, Kmetz John G, Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors/*metabolism, Male, Meszaros J Gary, Mice, Microvessels/drug effects/physiopathology, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/*metabolism, Ohanyan Vahagn A, Peptides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/agonists/antagonists & inhibitors/biosynthesis/*metabolism, Type 2/drug therapy/*metabolism, Vasoconstrictor Agents/pharmacology, Vasodilation/drug effects

Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation.

During heightened cardiac work, O2 consumption by the heart benefits energy production via mitochondria. However, some electrons leak from the respiratory chain and yield superoxide, which is rapidly metabolized into H2O2 by SOD2. To understand the…

Tags: 2015, Adenosine Triphosphate/biosynthesis, Animals, Arterial Pressure/drug effects, Bioenergetics, Blood Flow Velocity/drug effects, Cardiac function, Cardiac/drug effects/*enzymology, Catalase/pharmacology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Integrative Medical Sciences, Echocardiography, Female, Gene Expression, Heart/drug effects/*enzymology, Hydrogen Peroxide/*metabolism/pharmacology, Injections, Intravenous, Journal of molecular and cellular cardiology, Kang Patrick T, Luther Daniel J, Male, Meszaros J Gary, Metabolic dilation, Mice, Mitochondria, Myocardium/*enzymology, Myocytes, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Ohanyan Vahagn, Oxidation-Reduction, Oxygen Consumption/drug effects, Redox regulation, Signal Transduction, Stroke Volume/drug effects, Superoxide dismutase 2 (SOD2), Superoxide Dismutase/*genetics/metabolism, Transgenic, Transgenic mice, Vasodilation/*drug effects

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