Browse Items · NEOMED Bibliography Database

Transient receptor potential vanilloid 4 channel deletion regulates pathological but not developmental retinal angiogenesis.

Transient receptor potential vanilloid 4 (TRPV4) channels are mechanosensitive ion channels that regulate systemic endothelial cell (EC) functions such as vasodilation, permeability, and angiogenesis. TRPV4 is expressed in retinal ganglion cells,…

Role of iNOS in osteoarthritis: Pathological and therapeutic aspects.

Accumulating evidence suggests that inflammation has a key role in the pathogenesis of osteoarthritis (OA). Nitric oxide (NO) has been established as one of the major inflammatory mediators in OA and drives many pathological changes during the…

Tags: 2020, Ahmad Nashrah, Ansari Mohammad Y, Chondrocytes, Department of Anatomy & Neurobiology, Haqqi Tariq M, Inflammation, iNOS, iNOS inhibitor, Journal of cellular physiology, NEOMED College of Medicine, NITRIC oxide, Osteoarthritis, Oxidative Stress

Differential Expression and Cellular Distribution of gamma-Tubulin and beta III-Tubulin in Medulloblastomas and Human Medulloblastoma Cell Lines

In previous studies, we have shown overexpression and ectopic subcellular distribution of gamma-tubulin and beta III-tubulin in human glioblastomas and glioblastoma cell lines (Katsetos et al., 2006,] Neuropathol Exp Neurol 65:455-467; Katsetos et…

Modulation of Mast Cell Proliferative and Inflammatory Responses by Leukotriene D-4 and Stem Cell Factor Signaling Interactions

Mast cells (MCs) are important effector cells in asthma and pulmonary inflammation, and their proliferation and maturation is maintained by stem cell factor (SCF) via its receptor, c-Kit. Cysteinyl leukotrienes (cys-LTs) are potent inflammatory…

CELL-MEMBRANE POTENTIAL CHANGES FOLLOW EPSTEIN-BARR VIRUS BINDING

Tags: 1983, Cell Biology, Journal Article, Journal of cellular physiology, Physiology, Rosenthal K S, Shapiro H M

Autophagy plays an essential role in bone homeostasis.

Autophagy is very critical for multiple cellular processes. Autophagy plays a critical role in bone cell differentiation and function.

Tags: 2019, Al-Adlaan Asaad A, Ansari Mohammad Y, autophagosome, Autophagy, Department of Anatomy & Neurobiology, Hussein Nazar J, Jaber Fatima A, Journal of cellular physiology, Khan Nazir M, NEOMED College of Medicine, OSTEOBLAST, osteoclast, osteocytes, Safadi Fayez F

Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.

Nearly 60% of patients with head and neck squamous cell carcinoma (HNSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell migration and invasion, which are in part dependent on extracellular matrix degradation by…

Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas.

Nearly 50% of patients with oral squamous cell carcinoma (OSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell adhesion, migration, and invasion. Osteoactivin (OA) overexpression plays a role in metastases in…

Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.

Initial identification of osteoactivin (OA)/glycoprotein non-melanoma clone B (gpnmb) was demonstrated in an osteopetrotic rat model, where OA expression was increased threefold in mutant bones, compared to normal. OA mRNA and protein expression…

Osteoactivin induces transdifferentiation of C2C12 myoblasts into osteoblasts.

Osteoactivin (OA) is a novel osteogenic factor important for osteoblast differentiation and function. Previous studies showed that OA stimulates matrix mineralization and transcription of osteoblast specific genes required for differentiation. OA…

Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization.

Cilia are mechanosensing organelles that communicate extracellular signals into intracellular responses. Altered functions of primary cilia play a key role in the development of various diseases including polycystic kidney disease. Here, we show that…

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