Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease
Title
Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease
Creator
Casali BT; Reed-Geaghan EG
Publisher
Cells
Date
2021
2021-04
Description
Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic plasticity, in addition to their primary role as immune sentinels. In aging and neurodegenerative diseases generally, and Alzheimer's disease (AD) specifically, microglial function is altered in ways that significantly diverge from their homeostatic state, inducing a more detrimental inflammatory environment. In this review, we discuss the receptors, signaling, regulation and gene expression patterns of microglia that mediate their phenotype and function contributing to the inflammatory milieu of the AD brain, as well as strategies that target microglia to ameliorate the onset, progression and symptoms of AD.
Subject
inflammation; TREM2; neurodegenerative diseases; microglia; neuroinflammation; Alzheimer’s disease; s disease; Alzheimer’
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
journalArticle
URL Address
Search for Full-text
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Issue
4
Volume
10
NEOMED College
College of Pharmacy
NEOMED Department
Department of Pharmaceutical Sciences
NEOMED Postdoc Publications
Update Year & Number
May 2021 List
Citation
Casali BT; Reed-Geaghan EG, “Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease,” NEOMED Bibliography Database, accessed April 26, 2024, https://neomed.omeka.net/items/show/11650.