Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease

Title

Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease

Creator

Casali BT; Reed-Geaghan EG

Publisher

Cells

Date

2021
2021-04

Description

Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic plasticity, in addition to their primary role as immune sentinels. In aging and neurodegenerative diseases generally, and Alzheimer's disease (AD) specifically, microglial function is altered in ways that significantly diverge from their homeostatic state, inducing a more detrimental inflammatory environment. In this review, we discuss the receptors, signaling, regulation and gene expression patterns of microglia that mediate their phenotype and function contributing to the inflammatory milieu of the AD brain, as well as strategies that target microglia to ameliorate the onset, progression and symptoms of AD.

Subject

inflammation; TREM2; neurodegenerative diseases; microglia; neuroinflammation; Alzheimer’s disease; s disease; Alzheimer&#8217

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Issue

4

Volume

10

NEOMED College

College of Pharmacy

NEOMED Department

Department of Pharmaceutical Sciences
NEOMED Postdoc Publications

Update Year & Number

May 2021 List

Citation

Casali BT; Reed-Geaghan EG, “Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease,” NEOMED Bibliography Database, accessed August 2, 2021, https://neomed.omeka.net/items/show/11650.

Social Bookmarking