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Group II metabotropic glutamate receptors modulate sound evoked and spontaneous activity in the mouse inferior colliculus.

Little is known about the functions of group II metabotropic glutamate receptors (mGluRs2/3) in the inferior colliculus (IC)-a midbrain structure that is a major integration region of the central auditory system. We investigated how these receptors…

Tags: 2020, Auditory, Beebe NL, Department of Anatomy & Neurobiology, eNeuro, GABAergic, Galazyuk AV, January 2021 List, journalArticle, Kristaponyte I, LY354740, mGluR2/3, NEOMED College of Medicine, NEOMED Student Publications, neuromodulation, non-GABAergic, Schofield BR, Shanbhag SJ, Young JW

Mechanisms underlying enhancement of spontaneous glutamate release by group I mGluRs at a central auditory synapse

One emerging concept in neuroscience states that synaptic vesicles and the molecular machinery underlying spontaneous transmitter release are different from those underlying action potential-driven synchronized transmitter release. Differential…

Cholinergic projections from the pedunculopontine tegmental nucleus contact excitatory and inhibitory neurons in the inferior colliculus

The inferior colliculus processes nearly all ascending auditory information. Most collicular cells respond to sound, and for a majority of these cells, the responses can be modulated by acetylcholine (ACh). The cholinergic effects are varied and, for…

Knockdown Of Leptin A Expression Dramatically Alters Zebrafish Development

Using morpholino antisense oligonucleotide (MO) technology, we blocked leptin A or leptin receptor expression in embryonic zebrafish, and analyzed consequences of leptin A knock-down on fish development. Embryos injected with leptin A or leptin…

A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice

Located in the midbrain, the inferior colliculus (IC) is the hub of the central auditory system. Although the IC plays important roles in speech processing, sound localization, and other auditory computations, the organization of the IC…

Effects of artifact rejection and Bayesian weighting on the auditory brainstem response during quiet and active behavioral conditions.

PURPOSE: To evaluate the effects of 2 noise reduction techniques on the auditory brainstem response (ABR). METHOD: ABRs of 20 normal hearing adults were recorded during quiet and active behavioral conditions using 2 stimulus intensity levels. Wave V…

Simultaneous presentation of facial nerve neuroma and otosclerosis.

Otosclerosis often occurs as a unilateral mixed or conductive hearing loss. In the absence of retrocochlear findings, otologists usually do not pursue further diagnostic testing. A patient who presented to the Warren Otologic Group with a unilateral…

Ultrastructural characterization of GABAergic and excitatory synapses in the inferior colliculus.

In the inferior colliculus (IC) cells integrate inhibitory input from the brainstem and excitatory input from both the brainstem and auditory cortex. In order to understand how these inputs are integrated by IC cells identification of their synaptic…

Tags: 2014, Auditory, circuit, Department of Anatomy & Neurobiology, Frontiers in neuroanatomy, gamma-aminobutyric acid, inhibition, Killius Jeanette, Mellott Jeffrey G, Nakamoto Kyle T, NEOMED College of Medicine, Schofield Brett R, Sowick Colleen S, Storey-Workley Megan E, ultrastructure

Perineuronal nets and GABAergic cells in the inferior colliculus of guinea pigs.

Perineuronal nets (PNs) are aggregates of extracellular matrix that have been associated with neuronal plasticity, critical periods, fast-spiking cells and protection from oxidative stress. Although PNs have been reported in the auditory system in…

Tags: 2014, Auditory, Department of Anatomy & Neurobiology, Extracellular Matrix, Foster Nichole L, Frontiers in neuroanatomy, GABA, inhibition, Mellott Jeffrey G, midbrain, NEOMED College of Medicine, plasticity, Schofield Brett R

Cholinergic and non-cholinergic projections from the pedunculopontine and laterodorsal tegmental nuclei to the medial geniculate body in Guinea pigs.

The midbrain tegmentum is the source of cholinergic innervation of the thalamus and has been associated with arousal and control of the sleep/wake cycle. In general, the innervation arises bilaterally from the pedunculopontine tegmental nucleus (PPT)…

Tags: 2010, Acetylcholine, Arousal, Auditory, Department of Anatomy & Neurobiology, Frontiers in neuroanatomy, GABA, glutamate, Motts Susan D, NEOMED College of Medicine, Schofield Brett R, sleep, thalamus

Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss.

In childhood, partial hearing loss can produce prolonged deficits in speech perception and temporal processing. However, early therapeutic interventions targeting temporal processing may improve later speech-related outcomes. Gap detection is a…

Extracellular Molecular Markers and Soma Size of Inhibitory Neurons: Evidence for Four Subtypes of GABAergic Cells in the Inferior Colliculus.

UNLABELLED: Inhibition plays an important role in shaping responses to stimuli throughout the CNS, including in the inferior colliculus (IC), a major hub in both ascending and descending auditory pathways. Subdividing GABAergic cells has furthered…

Roles of inhibition in complex auditory responses in the inferior colliculus: inhibited combination-sensitive neurons.

We studied the functional properties and underlying neural mechanisms associated with inhibitory combination-sensitive neurons in the mustached bat's inferior colliculus (IC). In these neurons, the excitatory response to best frequency tones was…

Auditory responses in the cochlear nucleus of awake mustached bats: precursors to spectral integration in the auditory midbrain.

In the cochlear nucleus (CN) of awake mustached bats, single- and two-tone stimuli were used to examine how responses in major CN subdivisions contribute to spectrotemporal integrative features in the inferior colliculus (IC). Across CN subdivisions,…

A function for binaural integration in auditory grouping and segregation in the inferior colliculus.

Responses of neurons to binaural, harmonic complex stimuli in urethane-anesthetized guinea pig inferior colliculus (IC) are reported. To assess the binaural integration of harmonicity cues for sound segregation and grouping, responses were measured…

Tags: *Auditory Perception, 2015, Animals, Auditory, binaural integration, Evoked Potentials, Female, Guinea Pigs, harmonic complex, Inferior Colliculi/cytology/*physiology, inferior colliculus, Journal of neurophysiology, Magezi David A, Male, Nakamoto Kyle T, Neurons/physiology, Palmer Alan R, pitch, Shackleton Trevor M

Late maturation of backward masking in auditory cortex.

Speech perception relies on the accurate resolution of brief, successive sounds that change rapidly over time. Deficits in the perception of such sounds, indicated by a reduced ability to detect signals during auditory backward masking, strongly…

Tags: 2018, Auditory, cortex, Department of Anatomy & Neurobiology, detection, development, Donell Brittany M, Journal of neurophysiology, masking, Mattingly Michelle M, NEOMED College of Medicine, Rosen Merri J

Effects of artifact rejection and bayesian weighting on the auditory brainstem response during quiet and active behavioral conditions.

PURPOSE: To evaluate the effects of 2 noise reduction techniques on the auditory brainstem response (ABR). METHOD: ABRs of 20 normal hearing adults were recorded during quiet and active behavioral conditions using 2 stimulus intensity levels. Wave V…

Tags: *Artifacts, *Bayes Theorem, 2006, Adult, American journal of audiology, Auditory, Brain Stem/*physiology, Evoked Potentials, Female, Gans Donald, Humans, Male, Motor Activity/*physiology, Noise, Rest/physiology, Sanchez Jason Tait

Excitatory and facilitatory frequency response areas in the inferior colliculus of the mustached bat.

In the mustached bat's central nucleus of the inferior colliculus (ICC), many neurons display facilitatory or inhibitory responses when presented with two tones of distinctly different frequencies. Our previous studies have focused on spectral…

Tags: 2002, Acoustic Stimulation, Animal, Animals, Auditory, Auditory Perception/*physiology, Brain Stem, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Echolocation, Evoked Potentials, Hearing research, Inferior Colliculi/*physiology, NEOMED College of Medicine, Neurons/physiology, Portfors Christine V, Vocalization, Wenstrup Jeffrey J

Auditory nerve fiber differences in the normal and neurofilament deficient Japanese quail.

A primary axonal disease affecting the central and peripheral nervous system was discovered in a mutant strain of the Japanese quail, named quiver (Quv). We have previously demonstrated altered auditory evoked potentials in the neurofilament (NF)…

Tags: *Mutation, 2001, Animals, Auditory, Axons/ultrastructure, Brain Stem, Cochlear Nerve/*pathology/*physiopathology, Coturnix/genetics, Electron, Evoked Potentials, Hearing research, Kaga K, Microscopy, Mizutani M, Myelin Sheath/ultrastructure, Nerve Fibers/pathology/physiology, Neurofilament Proteins/*deficiency/*genetics, Sheykholeslami K

Binaural interaction of bone-conducted auditory brainstem responses in children with congenital atresia of the external auditory canal.

Bilateral bone-conducted auditory brainstem responses (BC-ABRs) were recorded in children with atresia of the external auditory canal bilaterally (AECB) in order to compare the response characteristics to normal hearing adults. The binaural…

An operant-based detection method for inferring tinnitus in mice.

BACKGROUND: Subjective tinnitus is a hearing disorder in which a person perceives sound when no external sound is present. It can be acute or chronic. Because our current understanding of its pathology is incomplete, no effective cures have yet been…

Noise-induced cochlear synaptopathy: Past findings and future studies.

For decades, we have presumed the death of hair cells and spiral ganglion neurons are the main cause of hearing loss and difficulties understanding speech in noise, but new findings suggest synapse loss may be the key contributor. Specifically,…

Prepulse inhibition of the acoustic startle reflex vs. auditory brainstem response for hearing assessment.

The high prevalence of noise-induced and age-related hearing loss in the general population has warranted the use of animal models to study the etiology of these pathologies. Quick and accurate auditory threshold determination is a prerequisite for…

Canertinib induces ototoxicity in three preclinical models.

Neuregulin-1 (NRG1) ligand and its epidermal growth factor receptor (EGFR)/ERBB family regulate normal cellular proliferation and differentiation in many tissues including the cochlea. Aberrant NRG1 and ERBB signaling cause significant hearing…

Development of tinnitus in CBA/CaJ mice following sound exposure.

Tinnitus, the perception of a sound without an external acoustic source, is a complex perceptual phenomenon affecting the quality of life in 17% of the adult population. Despite its ubiquity and morbidity, the pathophysiology of tinnitus is a work in…

Tags: 2011, Animals, Auditory, Brain Stem, Department of Anatomy & Neurobiology, Evoked Potentials, Galazyuk Alexander V, Inbred CBA, Journal of the Association for Research in Otolaryngology : JARO, Longenecker Ryan J, Mice, NEOMED College of Medicine, Noise/*adverse effects, Reflex, Startle, Tinnitus/*etiology/physiopathology

Inputs to combination-sensitive neurons of the inferior colliculus.

In the mustached bat, combination-sensitive neurons display integrative responses to combinations of acoustic elements in biosonar or social vocalizations. One type of combination-sensitive neuron responds to multiple harmonics of the…

Tags: *Brain Mapping, 1999, Acoustic Stimulation, Animals, Auditory, Brain Stem/*physiology, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Evoked Potentials, Grose C D, Inferior Colliculi/*physiology, Mittmann D H, NEOMED College of Medicine, Neurons/*physiology, The Journal of comparative neurology, Wenstrup J J

Browse Items (26 total)