Browse Items · NEOMED Bibliography Database

Rebound from Inhibition: Self-Correction against Neurodegeneration?

Neural networks play a critical role in establishing constraints on excitability in the central nervous system. Several recent studies have suggested that network dysfunction in the brain and spinal cord are compromised following insult by a…

Tags: 2017, Astrocytes, Calcium buffering, Calcium Channels, Department of Integrative Medical Sciences, Journal of clinical & cellular immunology, Lynch William P, Microglia, Motor neuron degeneration, NEOMED College of Medicine, NG2 glia, Post-inhibitory rebound firing, Rhythmic neural networks, Sivaramakrishnan Shobhana

High concentrations of divalent cations isolate monosynaptic inputs from local circuits in the auditory midbrain.

Hierarchical processing of sensory information occurs at multiple levels between the peripheral and central pathway. Different extents of convergence and divergence in top down and bottom up projections makes it difficult to separate the various…

Tags: 2013, Acoustic Stimulation, Animals, Cations, Divalent/*pharmacology, first spike latency, Frontiers in neural circuits, Grimsley Calum Alex, high divalents, Inferior Colliculi/drug effects/*physiology, inferior colliculus, local circuits, Mice, monosynaptic, Neural Inhibition/drug effects/*physiology, Reaction Time/drug effects/physiology, Sanchez Jason Tait, Sivaramakrishnan Shobhana, Synapses/drug effects/*physiology

Midbrain local circuits shape sound intensity codes.

Hierarchical processing of sensory information requires interaction at multiple levels along the peripheral to central pathway. Recent evidence suggests that interaction between driving and modulating components can shape both top down and bottom up…

Tags: 2013, Acoustic Stimulation, Animals, Auditory Pathways/*physiology, Auditory Perception/*physiology, Auditory Threshold/physiology, Frontiers in neural circuits, Grimsley Calum Alex, high divalents, Inferior Colliculi/*physiology, inferior colliculus, local circuits, Mice, monosynaptic, Neural Inhibition/*physiology, Neurons/physiology, Sanchez Jason Tait, Sivaramakrishnan Shobhana, sound intensity

Functional architecture of the inferior colliculus revealed with voltage-sensitive dyes.

We used optical imaging with voltage-sensitive dyes to investigate the spatio-temporal dynamics of synaptically evoked activity in brain slices of the inferior colliculus (IC). Responses in transverse slices which preserve cross-frequency connections…

L-type calcium channels refine the neural population code of sound level.

The coding of sound level by ensembles of neurons improves the accuracy with which listeners identify how loud a sound is. In the auditory system, the rate at which neurons fire in response to changes in sound level is shaped by local networks.…

Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.

Certain retroviruses induce progressive spongiform motor neuron disease with features resembling prion diseases and amyotrophic lateral sclerosis. With the neurovirulent murine leukemia virus (MLV) FrCasE, Env protein expression within glia leads to…

Tags: 2014, Action Potentials/physiology, Animals, Antigens/metabolism, auditory midbrain, Calcium/metabolism, Davey Robert A, Department of Integrative Medical Sciences, env/metabolism, Experimental/physiopathology, Gene Products, Hearing Loss/physiopathology, Inferior Colliculi/physiopathology/virology, inferior colliculus, Journal of neurophysiology, Leukemia, Leukemia Virus, Li Ying, Lynch William P, Membrane Potentials/physiology, Mice, Microglia/physiology/virology, Murine/*physiology, NEOMED College of Medicine, Neural Pathways/physiopathology, Neurodegenerative Diseases/*physiopathology, Neuroglia/physiology/virology, Neurons/*physiology/virology, Patch-Clamp Techniques, postinhibitory rebound neurons, Proteoglycans/metabolism, Retroviridae Infections/*physiopathology/virology, retrovirus, Sivaramakrishnan Shobhana, Tissue Culture Techniques, Tumor Virus Infections/*physiopathology/virology, Voltage-Sensitive Dye Imaging, voltage-sensitive dyes

Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.

Age-related hearing loss (AHL) is a multifactorial disorder characterized by a decline in peripheral and central auditory function. Here, we examined synaptic transmission in DBA/2 mice, which carry the AHL8 gene, at the identifiable glutamatergic…

An operant-based detection method for inferring tinnitus in mice.

BACKGROUND: Subjective tinnitus is a hearing disorder in which a person perceives sound when no external sound is present. It can be acute or chronic. Because our current understanding of its pathology is incomplete, no effective cures have yet been…

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