Browse Items · NEOMED Bibliography Database

Herpes simplex virus type 1 penetration initiates mobilization of cell surface proteins.

Changes in membrane structure resulting from herpes simplex virus 1 (HSV-1) penetration were detected using fluorescence photobleaching recovery methods. The effect could be blocked by inhibitors of viral and cellular processes involved in virus…

A critical period for long-term potentiation in the developing rat visual cortex.

The in vitro rodent visual cortical slice preparation demonstrates a critical period for long-term potentiation (LTP). Current source density (CSD) analysis reveals peak potentiation of both supra-(layers II-III) and infragranular (layers V) layers…

Tags: 1988, Aging, Animals, Brain research, Electric Stimulation, In Vitro Techniques, Neuronal Plasticity, Newborn, Perkins A T 4th, Rats, Teyler T J, Visual Cortex/*growth & development/physiology

The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro.

The duration of long-term potentiation (LTP) of the CA1 evoked field potential in rat hippocampal slices was significantly modulated by pre-treatment of slices with delta-9-tetrahydrocannabinol (THC) added to the incubation media. The three THC doses…

Tags: 1987, Animals, Brain research bulletin, Dronabinol/*pharmacology, Evoked Potentials/drug effects, Hippocampus/*drug effects/physiology, In Vitro Techniques, Kinetics, Male, Nowicky A V, Pyramidal Tracts/drug effects/physiology, Rats, Teyler T J, Time Factors, Vardaris R M

Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus.

The necessity of metabotropic glutamate receptors (mGluRs) in the induction of long-term potentiation (LTP) has recently been questioned. We examined the effect of (R,S)-alpha-methyl-4-caboxyphenylglycine (MCPG), a selective mGluR antagonist, on two…

Tags: 1995, Animals, Benzoates/*pharmacology, Calcium Channels/drug effects/metabolism/physiology, Electric Stimulation, Electrophysiology, Excitatory Amino Acid Antagonists/*pharmacology, Glycine/*analogs & derivatives/pharmacology, Grover L M, Hippocampus/drug effects/*physiology, In Vitro Techniques, Ion Channel Gating/drug effects, Little Z, Long-Term Potentiation/*drug effects, Metabotropic Glutamate/*antagonists & inhibitors, Neuroscience letters, Rats, Receptors, Teyler T J

Blockade of the late IPSP in rat CA1 hippocampal neurons by 2-hydroxy-saclofen.

The effects of the GABAB receptor antagonist 2-hydroxy-saclofen were studied using intracellular recording of synaptic potential from CA1 hippocampal neurons.

Tags: 1989, Action Potentials/drug effects, Animals, Baclofen/*analogs & derivatives/pharmacology, GABA-A Receptor Antagonists, GABA-A/*physiology, Harrison N L, Hippocampus/drug effects/*physiology, In Vitro Techniques, Kerr D I, Lambert N A, Neural Inhibition/*drug effects, Neuroscience letters, Ong J, Prager R H, Rats, Receptors, Teyler T J

Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+.

The mechanism of disinhibition produced by (+/-)-baclofen was studied using intracellular recording in area CA1 of rat hippocampal slices. Baclofen reversibly depressed monosynaptic IPSPs evoked by direct activation of interneurons in the presence of…

Tags: 1991, 2-Amino-5-phosphonovalerate/pharmacology, Animals, Baclofen/antagonists & inhibitors/*pharmacology, Barium/*pharmacology, Brain research, Drug Resistance/physiology, Evoked Potentials/drug effects, GABA-A/*drug effects, Harrison N L, Hippocampus/*drug effects, In Vitro Techniques, Interneurons/drug effects, Lambert N A, Neural Inhibition/drug effects, Quinoxalines/pharmacology, Rats, Receptors, Teyler T J

Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus.

The effects of adenosine on inhibitory synaptic transmission in area CA1 were examined using the rat hippocampal slice preparation and intracellular recording. Adenosine did not change fast inhibitory synaptic potentials (IPSPs) but depressed late…

Tags: 1991, 2-Amino-5-phosphonovalerate/pharmacology, Adenosine/*pharmacology, Animals, Evoked Potentials/drug effects, Hippocampus/drug effects/*physiology, In Vitro Techniques, Lambert N A, Membrane Potentials/drug effects, Neuroscience letters, Quinoxalines/pharmacology, Rats, Synapses/*drug effects, Synaptic Transmission/*drug effects, Teyler T J, Theophylline/analogs & derivatives/pharmacology

Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.

Enduring synaptic potentiation can be induced in area CA1 of hippocampus by tetanic stimulation and by exposure to a medium containing high Ca2+ concentration. Both tetanic stimulation and high Ca2+ induce potentiation through voltage-dependent,…

Tags: 1990, 2-Amino-5-phosphonovalerate/*pharmacology, Action Potentials/drug effects, Animals, Calcium/*pharmacology, Electric Stimulation, Grover L M, Hippocampus/drug effects/*physiology, In Vitro Techniques, N-Methyl-D-Aspartate, Neuronal Plasticity/*drug effects, Neuroscience letters, Neurotransmitter/antagonists & inhibitors/*physiology, Receptors, Teyler T J

Triethyltin exposure suppresses synaptic transmission in area CA1 of the rat hippocampal slice.

To examine the effects of TET on the electrophysiology of area CA1 of hippocampus, hippocampal slices were obtained from adult hooded rats and were maintained in vitro using standard techniques. Stimulating and recording electrodes were placed in the…

Tags: 1988, Animals, Evoked Potentials/drug effects, Female, Fountain S B, Hennes S K, Hippocampus/drug effects/*pathology/physiology, In Vitro Techniques, Neurotoxicology and teratology, Pyramidal Tracts/drug effects/*pathology/physiology, Rats, Synapses/drug effects/*physiology, Synaptic Transmission/*drug effects, Teyler T J, Ting Y L, Trialkyltin Compounds/*toxicity, Triethyltin Compounds/*toxicity

Characterizing neurotoxicity using the in vitro hippocampal brain slice preparation: heavy metals.

Tags: 1987, Animal Testing Alternatives, Animals, Fountain S B, Hippocampus/drug effects/*physiology, In Vitro Techniques, Metals/*toxicity, Neurons/drug effects/physiology, Neurotoxins/*toxicity, Progress in clinical and biological research, Pyramidal Tracts/drug effects/physiology, Teyler T J, Trimethyltin Compounds/toxicity

Development of potentiation in the dentate gyrus of rat: physiology and anatomy.

The physiological development of potentiating processes in the rat dentate gyrus were compared to morphological development. Rapid Golgi techniques were coupled with in vitro studies of dentate granule cell frequency potentiation, post-tetanic…

Tags: 1978, Animals, Brain research bulletin, Duffy C J, Female, Hippocampus/anatomy & histology/growth & development/*physiology, In Vitro Techniques, Inbred Strains, Male, Rats, Teyler T J

The effect of long-term treatment with deprenyl on basal and L-dopa evoked dopamine release in vitro from the corpus striatum of aged rats.

In the present experiment, male rats (15-17 months) were injected with deprenyl (0.25 mg/kg) three times per week for six months. At 21-23 months of age the male rats were sacrificed, the corpus striatum removed and superfused in vitro. Basal and…

Tags: 1991, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Aging/metabolism, Amphetamine/pharmacology, Animals, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, In Vitro Techniques, Journal of neural transmission. General section, Levodopa/pharmacology, Male, McDermott J L, Rats, Selegiline/*pharmacology

Testosterone causes direct relaxation of rat thoracic aorta.

Several recent studies have provided evidence that gonadal steroid hormones can exert acute (nongenomic) effects on both neural and vascular tissues. This study examines the acute effects of testosterone (T) on vascular reactivity of the rat thoracic…

Developmental alterations in N-methyl-D-aspartate stimulated [3H]norepinephrine release in rat brain cortex and hippocampus.

Developmental alterations in N-methyl-D-aspartate (NMDA)-stimulated[3H]norepinephrine release from rat brain cortical and hippocampal slices were studied. NMDA (10-1000 microM) resulted in a concentration-dependent increase in [3H]norepinephrine…

Tags: 1993, 2-Amino-5-phosphonovalerate/pharmacology, Animals, Brown L M, Cerebral Cortex/drug effects/*growth & development/metabolism, Female, Hippocampus/drug effects/*growth & development/metabolism, In Vitro Techniques, Male, N-Methylaspartate/*pharmacology, Neuroscience letters, Norepinephrine/*metabolism, Rats, Sprague-Dawley

A slice preparation preserving the callosal projection to contralateral visual cortex.

Due to the curved path they follow, the visual callosal projections to areas OC1 and OC2 of the rat visual cortex have been inaccessible to studies using brain slices. In this paper we describe a new slice preparation in which a curved cutting blade…

Tags: *Synaptic Transmission, 1990, Animals, Berry R L, Corpus Callosum/*physiology, Electrophysiology, Female, In Vitro Techniques, Inbred Strains, Journal of neuroscience methods, Male, Neurology/instrumentation, Nowicky A, Rats, Teyler T J, Visual Cortex/*physiology

Induction of LTP in rat primary visual cortex: tetanus parameters.

Long-term potentiation (LTP), intensively studied in the hippocampus as a possible mnemonic device, has begun to be studied in the neocortex. In this study the effects of varying tetanic stimulus parameters on LTP of field potentials recorded from…

Tags: 1989, Animals, Berry R L, Brain research, Electric Stimulation, Female, Han T Z, In Vitro Techniques, Male, Rats, Reaction Time/physiology, Teyler T J, Visual Cortex/*physiology

Persistent left ventricular dysfunction after cocaine treatment in rabbits.

The present study was undertaken to determine whether the diminished cardiac performance associated with cocaine administration persists after the drug has been eliminated from the body. Cocaine (5 or 10 mg/kg iv) was administered to conscious (n =…

Acute exercise attenuates phenylephrine-induced contraction of rabbit isolated aortic rings.

Factors associated with a single bout of dynamic exercise (increased circulating catecholamines, increased body temperature, and decreased pH) are known to attenuate the vascular response to alpha-adrenergic receptor activation. Therefore, we…

Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins.

BACKGROUND: Metabotropic glutamate receptors (mGluRs) regulate neuronal excitability and synaptic strength. The group I mGluRs, mGluR1 and 5, are widespread in the brain and localize to post-synaptic sites. The Homer protein family regulates group I…

Sex differences in methamphetamine-evoked striatal dopamine output are abolished following gonadectomy: comparisons with potassium-evoked output and responses in prepubertal mice.

Sex differences are reported for methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic system. In an attempt to understand some of the bases for these differences, we investigated MA-evoked dopamine (DA) responses from…

Tags: 2005, Animals, Dluzen Dean E, Dopamine Uptake Inhibitors/*pharmacology, Dopamine/*metabolism, Female, In Vitro Techniques, Male, Methamphetamine/*pharmacology, Mice, Neostriatum/drug effects/*metabolism, Neuroendocrinology, Orchiectomy, Ovariectomy, Potassium/*pharmacology, Salvaterra Ty J, Sex Characteristics, Sexual Maturation

Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus.

1. gamma-Aminobutyric acidA (GABAA) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current…

Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.

GABAergic transmission in the avian cochlear nucleus magnocellularis (NM) of the chick is subject to modulation by gamma-aminobutyric acid type B (GABA(B)) autoreceptors. Here, I investigated modulation of GABAergic transmission in NM by metabotropic…

Tags: 2-Amino-5-phosphonovalerate/pharmacology, 2007, Amino Acids/pharmacology, Animals, Chickens/*physiology, Cochlear Nucleus/*cytology/*physiology, Department of Anatomy & Neurobiology, Electric Stimulation, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/physiology, GABA-B Receptor Agonists, GABA-B Receptor Antagonists, GABA-B/physiology, gamma-Aminobutyric Acid/*physiology, Glycine/analogs & derivatives/pharmacology, In Vitro Techniques, Journal of neurophysiology, Kinetics, Lu Yong, Membrane Potentials/drug effects, Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology, Models, NEOMED College of Medicine, Neurological, Neurons/*physiology, Patch-Clamp Techniques, Receptors, Resorcinols/pharmacology, Synapses/physiology, Synaptic Transmission/*physiology, Xanthenes/pharmacology

L-type calcium channels refine the neural population code of sound level.

The coding of sound level by ensembles of neurons improves the accuracy with which listeners identify how loud a sound is. In the auditory system, the rate at which neurons fire in response to changes in sound level is shaped by local networks.…

Control of a depolarizing GABAergic input in an auditory coincidence detection circuit.

Neurons in the chicken nucleus laminaris (NL), the third-order auditory neurons that detect the interaural time differences that enable animals to localize sounds in the horizontal plane, receive glutamatergic excitation from the cochlear nucleus…

Effect of neuropeptide Y on hemodynamics of the rabbit lung.

We evaluated the effect of neuropeptide Y (NPY) on the hemodynamics of the isolated rabbit lung perfused at constant flow and outflow pressure. Doses of 10(-8) and 10(-7) M NPY increased pulmonary arterial pressure (Ppa) from 11.5 +/- 1.0 (SE) mmHg…

Tags: 1998, Animals, Cisterna Magna, Hemodynamics/*physiology, In Vitro Techniques, Injections, Journal of applied physiology (Bethesda, Md. : 1985), Lang S A, Maron M B, Neuropeptide Y/blood/pharmacology/*physiology, Norepinephrine/pharmacology, Perfusion, Pulmonary Circulation/drug effects/*physiology, Rabbits, Sympathetic Nervous System/drug effects/physiology, Vascular Resistance/drug effects/physiology, Vasoconstriction/drug effects/physiology, Vasoconstrictor Agents/pharmacology, Veratrine/administration & dosage/pharmacology

Role of EDRF in the cardiopulmonary dysfunction produced by massive sympathetic activation.

This study was undertaken to determine whether endothelium-derived relaxing factor (EDRF) modulates the pulmonary and systemic hemodynamic responses to massive sympathetic nervous system (SNS) activation and, in so doing, also modulates the degree of…

Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function.

Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart,…

Time course of blood volume changes in an isolated lung lobe after venous pressure elevation.

The elevation of venous pressure (Pv) in isolated perfused organs causes organ weight to increase in a biphasic manner. The initial rapid phase results primarily from an increase in blood volume (BV), whereas the second slower phase is generally…

Tags: *Blood Volume/drug effects, *Pulmonary Circulation, *Venous Pressure, 1994, Animals, Dogs, Extravascular Lung Water/metabolism, Female, In Vitro Techniques, Indicator Dilution Techniques, Indocyanine Green, Journal of applied physiology (Bethesda, Md. : 1985), Lane S M, Lung/*physiology, Male, Maron M B, Papaverine/pharmacology, Perfusion, Time Factors

Effect of peak inspiratory pressure on the filtration coefficient in the isolated perfused rat lung.

Positive inspiratory pressure- (PIP) ventilated, isolated rat lungs become edematous when perfused at rates approximately the normal cardiac output. The study was conducted to test the hypothesis that high peak inspiratory pressures contribute to the…

Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit.

We measured agonist-induced changes in the iliac artery blood flow velocity (IFV) independent of baroreflex-mediated compensatory mechanisms in chronically instrumented New Zealand White rabbits (n = 8). Animals were instrumented with a Doppler flow…

Circulating neuropeptide Y does not produce pulmonary hypertension during massive sympathetic activation.

We tested the possibility that neuropeptide Y (NPY) may contribute to the pulmonary hypertension that occurs after massive sympathetic activation produced by intracisternal veratrine administration in the chloralose-anesthetized dog. In six dogs,…

Tags: 1992, Adrenal Glands/drug effects/physiology, Adrenalectomy, Animals, Dogs, Hypertension, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Lang S A, Maender K C, Maron M B, Neuropeptide Y/*physiology, Norepinephrine/pharmacology, Pilati C F, Pulmonary Circulation/drug effects, Pulmonary/chemically induced/*physiopathology, Sympathetic Nervous System/*physiology, Veratrine/pharmacology

Pulmonary vasoconstriction in a canine model of neurogenic pulmonary edema.

The intracisternal administration of veratrine to the chloralose-anesthetized dog produces pulmonary hypertension (PH) and neurogenic pulmonary edema (NPE). To determine whether pulmonary vasoconstriction, mediated by a circulating agent, contributes…

Effect of elevated vascular pressure transients on protein permeability in the lung.

Neurogenic pulmonary edema (NPE) may develop in individuals with head trauma or seizures and is generally thought to have a hydrostatic basis in the severe degree of pulmonary hypertension that occurs. Recently, it has been suggested that vascular…

Tags: *Blood Pressure, 1989, Animals, Blood Proteins/*metabolism, Dogs, Female, Hypertension/physiopathology, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Lung/metabolism/*physiopathology, Male, Maron M B, Pulmonary Edema/*etiology/metabolism/physiopathology

Effect of papaverine on pulmonary vascular permeability to proteins.

Previous studies have suggested that papaverine, a drug commonly used in studies of transvascular fluid and solute exchange to eliminate confounding effects of changes in vascular tone, may itself increase vascular permeability. In this study, we…

Tags: 1988, Animals, Blood Proteins/*metabolism, Capillary Permeability/*drug effects, Dogs, Female, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Male, Maron M B, Osmosis, Papaverine/blood/*pharmacology, Pilati C F, Pulmonary Circulation/*drug effects, Serotonin/pharmacology, Vasodilation/drug effects, Water-Electrolyte Balance/drug effects

Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats.

Deoxycorticosterone acetate (DOCA)-salt hypertension develops to a greater extent in male (M) than in female (F) rats. To determine the role of the vasculature, reactivity to arginine vasopressin (AVP) and prostanoid output were examined in the…

Factors involved in left ventricular dysfunction after massive sympathetic activation.

We sought to determine whether catecholamines are responsible for the depressed left ventricular (LV) function that follows massive sympathetic nervous system (SNS) activation and whether the additional myocardial energy demands of

Tags: *Ventricular Function, 1992, Animals, Blood Pressure/drug effects/physiology, Bosso F J, Catecholamines/physiology, Female, Heart Conduction System/*physiology, Heart Diseases/*physiopathology, Heart Rate/drug effects, In Vitro Techniques, Left, Male, Maron M B, Pilati C F, Rabbits, Sympathetic Nervous System/drug effects/*physiology, The American journal of physiology, Veratrine/pharmacology

Redox-dependent coronary metabolic dilation.

We have observed that hydrogen peroxide (H2O2), the dismutated product of superoxide, is a coronary metabolic dilator and couples myocardial oxygen consumption to coronary blood flow. Because the chemical activity of H2O2 favors its role as an…

Tags: *Paracrine Communication, *Vasodilation/drug effects, 2007, Acetylcysteine/pharmacology, American journal of physiology. Heart and circulatory physiology, Animals, Antioxidants/pharmacology, Cardiac/drug effects/*metabolism, Chilian William M, Conditioned/metabolism, Coronary Vessels/drug effects/enzymology/*metabolism, Culture Media, Department of Integrative Medical Sciences, Dick Gregory M, Dithiothreitol/pharmacology, Enzyme Activation, Fluorescence, Hydrogen Peroxide/metabolism, Imidazoles/pharmacology, In Vitro Techniques, Kiyooka Takahiko, Microscopy, Myocytes, NEOMED College of Medicine, Nitroprusside/pharmacology, Oxidation-Reduction, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism, Park Yoonjung, Phosphorylation, Protein Kinase Inhibitors/pharmacology, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reducing Agents/pharmacology, Rocic Petra, Rogers Paul A, Saitoh Shu-ichi, Sulfhydryl Compounds/*metabolism, Swafford Albert, Vasodilator Agents/pharmacology, Viswanathan Chandrasekar, Wistar, Zhang Cuihua

Long-term potentiation induces synaptic plasticity at nontetanized adjacent synapses.

The two forms of long-term potentiation (LTP) and one form of long-term depression (LTD) in hippocampal area CA1 are induced by different afferent tetani: LTD is induced by a 3- to 5-Hz tetanus, whereas higher frequencies are necessary for LTP…

Tags: 1996, Action Potentials/physiology, Animals, Coussens C M, Electric Stimulation/methods, Excitatory Postsynaptic Potentials/physiology, In Vitro Techniques, Learning & memory (Cold Spring Harbor, N.Y.), Long-Evans, Long-Term Potentiation/*physiology, Neuronal Plasticity/*physiology, Rats, Synapses/*physiology, Teyler T J

Two components of long-term potentiation induced by different patterns of afferent activation.

Long-term potentiation (LTP) of excitatory synaptic transmission could be a mechanism underlying memory. Induction of LTP requires Ca2+ influx into postsynaptic neurons through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in…

Tags: 1990, 2-Amino-5-phosphonovalerate/*pharmacology, Afferent Pathways/physiology, Animals, Calcium/*physiology, Grover L M, Hippocampus/*physiology, In Vitro Techniques, Membrane Potentials, Memory/*physiology, N-Methyl-D-Aspartate/*physiology, Nature, Neuronal Plasticity, Receptors, Synaptic Transmission, Teyler T J, Time Factors

Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats.

In the present experiment we examined the effects of an in vitro infusion of nicotine (10 microM) upon dopamine release from superfused striatum of castrated male and female rats treated or not treated with estrogen. Estrogen exerted bidirectional…

Tags: 1997, Anderson L I, Animals, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Estradiol/*pharmacology, Female, In Vitro Techniques, Kinetics, Male, Neuroscience letters, Nicotine/*pharmacology, Orchiectomy, Ovariectomy, Rats, Sex Characteristics, Sprague-Dawley

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