Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit.

Title

Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit.

Creator

Howard M G; DiCarlo S E

Publisher

Journal of applied physiology (Bethesda, Md. : 1985)

Date

1992
1992-12

Description

We measured agonist-induced changes in the iliac artery blood flow velocity (IFV) independent of baroreflex-mediated compensatory mechanisms in chronically instrumented New Zealand White rabbits (n = 8). Animals were instrumented with a Doppler flow probe around the right common iliac artery. A Teflon catheter was inserted into the right iliolumbar artery for local infusion of the vasoactive agonists. Another Teflon catheter was inserted in the left femoral artery for the measurement of pulsatile and mean arterial (MAP) blood pressures and heart rate (HR). The alpha-adrenergic receptor agonist phenylephrine (PE, 1.32-10.0 micrograms), the beta 1- and beta 2-adrenergic receptor agonist isoproterenol (IP, 0.022-0.11 micrograms), and the purinergic receptor agonist adenosine (AD, 10.0-100.0 micrograms) were injected into the functionally isolated hindlimb, and dose-response curves were generated. Changes in IFV were obtained without changes in MAP or HR. Exercise increased HR, MAP, and IFV (65.3 +/- 7.1 beats/min, 11.1 +/- 2.2 mmHg, and 2.2 +/- 0.3 kHz, respectively). The maximum responses to PE, AD, and IP were reduced 29.0 +/- 6.7, 50.7 +/- 8.5, and 61.0 +/- 8.1%, respectively, after exercise. In conclusion, exercise attenuated adrenergic and purinergic receptor-mediated vascular responses in the intact conscious rabbit.

Subject

Adenosine/pharmacology; Adrenergic/physiology; Animals; Blood Vessels/*physiology; Dose-Response Relationship; Drug; Hindlimb/physiology; In Vitro Techniques; Isoproterenol/pharmacology; Phenylephrine/pharmacology; Physical Exertion/*physiology; Pressoreceptors/physiology; Purinergic/physiology; Rabbits; Receptors; Reflex/physiology; Regional Blood Flow/physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

2662–2667

Issue

6

Volume

73

Citation

Howard M G; DiCarlo S E, “Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit.,” NEOMED Bibliography Database, accessed June 21, 2021, https://neomed.omeka.net/items/show/4648.

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