Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.

Title

Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.

Creator

Grover L M; Teyler T J

Publisher

Neuroscience letters

Date

1990
1990-06

Description

Enduring synaptic potentiation can be induced in area CA1 of hippocampus by tetanic stimulation and by exposure to a medium containing high Ca2+ concentration. Both tetanic stimulation and high Ca2+ induce potentiation through voltage-dependent, post-synaptic mechanisms. Tetanus-induced long-term potentiation (LTP) was blocked by 50 microM D,L-2-amino-5-phosphonovalerate (APV) as previously reported by others. In contrast, Ca2(+)-induced long-lasting potentiation was not reduced by 50 microM APV. Thus the mechanisms by which tetanic stimulation and exposure to high Ca2+ induce synaptic potentiation may differ.

Subject

Animals; Action Potentials/drug effects; Electric Stimulation; In Vitro Techniques; Hippocampus/drug effects/*physiology; 2-Amino-5-phosphonovalerate/*pharmacology; Neuronal Plasticity/*drug effects; Calcium/*pharmacology; Receptors; N-Methyl-D-Aspartate; Neurotransmitter/antagonists & inhibitors/*physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

309–314

Issue

3

Volume

113

Citation

Grover L M; Teyler T J, “Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.,” NEOMED Bibliography Database, accessed June 21, 2021, https://neomed.omeka.net/items/show/5449.

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