Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.
Title
Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.
Creator
Grover L M; Teyler T J
Publisher
Neuroscience letters
Date
1990
1990-06
Description
Enduring synaptic potentiation can be induced in area CA1 of hippocampus by tetanic stimulation and by exposure to a medium containing high Ca2+ concentration. Both tetanic stimulation and high Ca2+ induce potentiation through voltage-dependent, post-synaptic mechanisms. Tetanus-induced long-term potentiation (LTP) was blocked by 50 microM D,L-2-amino-5-phosphonovalerate (APV) as previously reported by others. In contrast, Ca2(+)-induced long-lasting potentiation was not reduced by 50 microM APV. Thus the mechanisms by which tetanic stimulation and exposure to high Ca2+ induce synaptic potentiation may differ.
Subject
Animals; Action Potentials/drug effects; Electric Stimulation; In Vitro Techniques; Hippocampus/drug effects/*physiology; 2-Amino-5-phosphonovalerate/*pharmacology; Neuronal Plasticity/*drug effects; Calcium/*pharmacology; Receptors; N-Methyl-D-Aspartate; Neurotransmitter/antagonists & inhibitors/*physiology
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Citation
Grover L M; Teyler T J, “Differential effects of NMDA receptor antagonist APV on tetanic stimulation induced and calcium induced potentiation.,” NEOMED Bibliography Database, accessed April 26, 2024, https://neomed.omeka.net/items/show/5449.