Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats.

Mesenteric vascular responses to vasopressin during development of DOCA-salt hypertension in male and female rats.

Stallone J N

The American journal of physiology

1995

1995-01

Deoxycorticosterone acetate (DOCA)-salt hypertension develops to a greater extent in male (M) than in female (F) rats. To determine the role of the vasculature, reactivity to arginine vasopressin (AVP) and prostanoid output were examined in the isolated perfused mesenteric vasculature of hypertensive (HT) and normotensive-control (NTC) M and F rats after acute (1-wk) and chronic (4-wk)

6-Ketoprostaglandin F1 alpha/metabolism; Analysis of Variance; Animals; Arginine Vasopressin/*pharmacology; Blood Pressure/drug effects; Desoxycorticosterone; Dietary; Dinoprostone/metabolism; Dose-Response Relationship; Drug; Female; Hypertension/chemically induced/*physiopathology; In Vitro Techniques; Male; Prostaglandins/analysis/*metabolism; Rats; Reference Values; Sex Characteristics; Sodium; Splanchnic Circulation/drug effects/*physiology; Sprague-Dawley

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