Role of EDRF in the cardiopulmonary dysfunction produced by massive sympathetic activation.

Title

Role of EDRF in the cardiopulmonary dysfunction produced by massive sympathetic activation.

Creator

Pilati C F; Maron M B; Bosso F J

Publisher

Journal of applied physiology (Bethesda, Md. : 1985)

Date

1995
1995-05

Description

This study was undertaken to determine whether endothelium-derived relaxing factor (EDRF) modulates the pulmonary and systemic hemodynamic responses to massive sympathetic nervous system (SNS) activation and, in so doing, also modulates the degree of SNS-induced left ventricular (LV) dysfunction and the likelihood for pulmonary edema formation. The SNS of 13 anesthetized untreated rabbits and 14 anesthetized rabbits pretreated with the EDRF inhibitor, N omega-nitro-L-arginine (L-NNA, 20 mg/kg), was massively activated with an intracisternal injection of veratrine. Pulmonary and systemic arterial pressures increased to the same extent in both groups, but LV end-diastolic pressure was significantly lower in untreated rabbits. During this time, cardiac output decreased by 37% in L-NNA pretreated rabbits compared with 8% in untreated animals. Peak systemic and pulmonary vascular resistances increased significantly in L-NNA rabbits, whereas only systemic vascular resistance increased significantly in untreated rabbits. However, this increase in systemic vascular resistance was threefold less than that observed for L-NNA-treated animals. Although the degree of LV dysfunction was greater in the L-NNA rabbits, pulmonary edema developed less frequently in this group. We suggest that when EDRF release is inhibited during massive SNS activity, pulmonary vascular resistance increases markedly, which causes the right ventricle to fail. We further suggest that the reduced right ventricular output maintains pulmonary microvascular pressure below levels required for edema development.

Subject

Animals; Arginine/analogs & derivatives/pharmacology; Epinephrine/blood; Extravascular Lung Water/drug effects/metabolism; Hemodynamics/drug effects; In Vitro Techniques; Left/*physiopathology; Nitric Oxide/antagonists & inhibitors/biosynthesis/*physiology; Nitroarginine; Norepinephrine/blood; Pulmonary Circulation/drug effects; Pulmonary Edema/*physiopathology; Rabbits; Right/drug effects/physiology; Sympathetic Nervous System/drug effects/*physiology; Ventricular Dysfunction; Ventricular Function; Veratrine/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1642–1650

Issue

5

Volume

78

Citation

Pilati C F; Maron M B; Bosso F J, “Role of EDRF in the cardiopulmonary dysfunction produced by massive sympathetic activation.,” NEOMED Bibliography Database, accessed September 28, 2022, https://neomed.omeka.net/items/show/4655.

Social Bookmarking