A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice

Title

A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice

Creator

Goyer David; Silveira Marina A; George Alexander P; Beebe Nichole L; Edelbrock Ryan M; Malinski Peter T; Schofield Brett R; Roberts Michael T

Publisher

eLife

Date

2019
2019-04

Description

Located in the midbrain, the inferior colliculus (IC) is the hub of the central auditory system. Although the IC plays important roles in speech processing, sound localization, and other auditory computations, the organization of the IC microcircuitry remains largely unknown. Using a multifaceted approach in mice, we have identified vasoactive intestinal peptide (VIP) neurons as a novel class of IC principal neurons. VIP neurons are glutamatergic stellate cells with sustained firing patterns. Their extensive axons project to long-range targets including the auditory thalamus, auditory brainstem, superior colliculus, and periaqueductal gray. Using optogenetic circuit mapping, we found that VIP neurons integrate input from the contralateral IC and the dorsal cochlear nucleus. The dorsal cochlear nucleus also drove feedforward inhibition to VIP neurons, indicating that inhibitory circuits within the IC shape the temporal integration of ascending inputs. Thus, VIP neurons are well-positioned to influence auditory computations in a number of brain regions.

Subject

auditory; Inferior colliculus; mouse; neural circuits; neuron types; neuroscience; optogenetics; VIP

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Volume

8

Citation

Goyer David; Silveira Marina A; George Alexander P; Beebe Nichole L; Edelbrock Ryan M; Malinski Peter T; Schofield Brett R; Roberts Michael T, “A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice,” NEOMED Bibliography Database, accessed January 16, 2021, https://neomed.omeka.net/items/show/6381.

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