Browse Items (16 total)
- Tags: Cell Proliferation/drug effects
Anthocyanin-rich black currant extract suppresses the growth of human hepatocellular carcinoma cells.
Tags: *Phytotherapy, *Ribes/chemistry, 2010, Antineoplastic Agents, Antioxidants/*therapeutic use, Bhatia Deepak, Bishayee Anupam, Carcinoma, Cell Proliferation/drug effects, Darvesh Altaf S, Department of Pharmaceutical Sciences, Drug Evaluation, Fruit/chemistry, Haznagy-Radnai Erzsebet, Hep G2 Cells, Hepatocellular/*prevention & control, Hohmann Judit, Humans, Liver Neoplasms/*prevention & control, Mbimba Thomas, Morazzoni Paolo, Natural product communications, NEOMED College of Pharmacy, Phytogenic/analysis, Plant Extracts/pharmacology/therapeutic use, Preclinical, Sipos Peter
Mechanism of Breast Cancer Preventive Action of Pomegranate: Disruption of Estrogen Receptor and Wnt/beta-Catenin Signaling Pathways.
Tags: 10-Dimethyl-1, 2-benzanthracene/pharmacology, 2015, 9, Animals, Anticarcinogenic Agents/*pharmacology, beta Catenin/*metabolism, beta-catenin, Bishayee Anupam, Breast Neoplasms/*drug therapy/metabolism, Cell Proliferation/drug effects, Cell Transformation, Chemoprevention/methods, Cyclin D1, DMBA, Down-Regulation/drug effects, Estrogen Receptor alpha/metabolism, estrogen receptors, Estrogen/*metabolism, Female, mammary tumorigenesis, Mandal Animesh, Molecules (Basel, Switzerland), Neoplastic/drug effects/metabolism, pomegranate (Punica granatum L.), Punicaceae/*chemistry, Rats, Receptors, Sprague-Dawley, Wnt Proteins/*metabolism, Wnt Signaling Pathway/*drug effects
Type VI collagen induces cardiac myofibroblast differentiation: implications for postinfarction remodeling.
Tags: 2006, American journal of physiology. Heart and circulatory physiology, Angiotensin II/pharmacology, Animals, Cell Differentiation/*drug effects, Cell Proliferation/drug effects, Cells, Collagen Type I/physiology, Collagen Type III/physiology, Collagen Type VI/*physiology, Coronary Vessels/pathology, Cultured, Department of Integrative Medical Sciences, Doane Kathleen J, Extracellular Matrix/*physiology, Fibroblasts/*cytology, Fibrosis/etiology, Folkesson Hans G, Horne Walter I, Ligation, Male, Maron Michael B, Mase Sharon E, Meszaros J Gary, Myocardial Infarction/physiopathology, Naugle Jennifer E, NEOMED College of Medicine, Olson Erik R, Pilati Charles F, Rats, Sprague-Dawley, Ventricular Remodeling/*physiology, Zhang Xiaojin
Characterization of ex vivo-generated bovine and human cartilage by immunohistochemical, biochemical, and magnetic resonance imaging analyses.
Tags: 2010, Aged, Animals, Articular/drug effects/growth & development/*metabolism, Bartusik Dorota, Cartilage, Cattle, Cell Proliferation/drug effects, Collagen Type II/metabolism, Culture Media/pharmacology, Cytokines/pharmacology, Department of Anatomy & Neurobiology, Department of Family & Community Medicine, Fishbein Kenneth W, Glycosaminoglycans/metabolism, Horton Walter E Jr, Humans, Immunohistochemistry, Magnetic Resonance Spectroscopy, McBurney Denise L, Middle Aged, Murray Travis, NEOMED College of Medicine, Nugent Ashleigh E, Ramaswamy Sharan, Reiter David A, Spencer Richard G, Tissue engineering. Part A, Tissue Engineering/*methods
Tags: 2015, Adapala Ravi K, Animals, Antineoplastic Agents/pharmacology, Cappelli Holly C, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Dudley Andrew C, Endothelial Cells/drug effects/metabolism, Kondeti Vinay, Leucine/analogs & derivatives/pharmacology, MAP Kinase Signaling System, Meszaros J Gary, Mice, NEOMED College of Medicine, Neoplasms/drug therapy/*metabolism/pathology, Neovascularization, Paruchuri Sailaja, Pathologic/drug therapy, Scientific reports, Sulfonamides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/drug effects/genetics/*metabolism, Up-Regulation
Tags: 2017, Angiogenesis Inducing Agents/*metabolism, Animals, Cell Movement/drug effects, Cell Proliferation/drug effects, Cells, Chick Embryo, Cultured, Department of Integrative Medical Sciences, Endothelium, Female, Gene Expression Regulation/drug effects, Habib N, Humans, Inbred C57BL, Krukovets I, Male, Mice, Muppala S, Muscle, NEOMED College of Medicine, Neovascularization, Oncogene, Pathologic/drug therapy/metabolism/*pathology, Plow E, Raman P, Signal Transduction/drug effects, Smooth, Stenina-Adognravi O, Thrombospondins/*physiology, Transforming Growth Factor beta/*pharmacology, Vascular/drug effects/metabolism/*pathology, Verbovetsky D, Xiao R, Yendamuri R
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.
Tags: 2016, Adapala R K, Animals, Calcium Signaling/genetics, Cappelli H C, Carcinoma, Cell Line, Cell Proliferation/drug effects, Chilian W M, Cisplatin/administration & dosage, Department of Integrative Medical Sciences, Dudley A C, Endothelium, Gene Expression Regulation, Ghosh K, Humans, Ingber D E, Keshamouni V, Klagsbrun M, Leucine/administration & dosage/analogs & derivatives, Lewis Lung/drug therapy/*genetics/pathology, Meszaros J G, Mice, NEOMED College of Medicine, Neoplastic/drug effects, Neovascularization, Oncogene, Paruchuri S, Pathologic/drug therapy/*genetics/pathology, Sulfonamides/administration & dosage, Thodeti C K, Thoppil R J, TRPV Cation Channels/agonists/biosynthesis/*genetics, Tumor, Vascular Endothelial Growth Factor A/genetics, Vascular/drug effects/*pathology
Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats.
Tags: *Dietary Supplements, *Mammary Neoplasms, 10-Dimethyl-1, 2-benzanthracene/*toxicity, 2014, 9, Aizoaceae/*chemistry, Animals, Apoptosis, Bax, Bcl-2, bcl-2-Associated X Protein/metabolism, beta-catenin, Bishayee Anupam, breast cancer, Carcinogens/*toxicity, Cell Proliferation, Cell Proliferation/drug effects, Chemoprevention, Cyclin D1, DMBA, Experimental/chemically induced/metabolism/pathology/prevention & control, Humans, Male, Mandal Animesh, Medicinal/*chemistry, Mutation research, Phytotherapy/*methods, Plants, Proliferating Cell Nuclear Antigen/metabolism, Rats, Sprague-Dawley, Trianthema portulacastrum, Up-Regulation/drug effects, Wnt Signaling Pathway/drug effects
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Tags: 2011, Animals, Anthocyanins/*therapeutic use, Anticarcinogenic Agents/therapeutic use, Apoptosis/drug effects, bcl-2-Associated X Protein/metabolism, Bishayee Anupam, Cell Proliferation/drug effects, Chemoprevention, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diethylnitrosamine, Down-Regulation, Experimental/metabolism/pathology, Folkesson Hans G, Haznagy-Radnai Erzsebet, Hohmann Judit, Liver Neoplasms, Liver Neoplasms/chemically induced/*prevention & control, Liver/pathology, Male, Mbimba Thomas, NEOMED College of Pharmacy, Phenobarbital, Plant Extracts/*therapeutic use, Proliferating Cell Nuclear Antigen/metabolism, Proto-Oncogene Proteins c-bcl-2/metabolism, Rats, Ribes/chemistry, Sipos Peter, Sprague-Dawley, The Journal of nutritional biochemistry, Thoppil Roslin J, Up-Regulation
Tags: 2004, alpha-Macroglobulins/immunology/metabolism, Antigens, Carrier Proteins/immunology/metabolism/*physiology, CD/drug effects/immunology, Cell Proliferation/drug effects, Cellular immunology, Cytokines/*biosynthesis/drug effects, Female, Glycodelin, Glycoproteins/immunology/metabolism/*physiology, Humans, Interleukin-2/biosynthesis, Interleukin-4/biosynthesis, Kinetics, Kiyatkina Nadya, Koo Peter H, LEUKOCYTES, Low Density Lipoprotein Receptor-Related Protein-1, Lymphocyte Activation/immunology, Mononuclear/drug effects/immunology, Pregnancy, Pregnancy Proteins/immunology/metabolism/*physiology, Protein Binding, Skornicka Erin L, T-Lymphocytes/cytology/drug effects/*immunology, Time Factors, Tykocinski Mark L, Weber Matthew C
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Tags: 2009, Animal, Animals, Anticarcinogenic Agents/*antagonists & inhibitors/pharmacology, Antitumor, Apoptosis/*drug effects, Bishayee Anupam, Body Weight/drug effects, Cell Proliferation/drug effects, Chemico-biological interactions, Dhir Neetika, Diethylnitrosamine, Disease Models, Dose-Response Relationship, Drinking/drug effects, Drug, Drug Screening Assays, Eating/drug effects, Experimental/chemically induced/pathology/*prevention & control, Female, Immunohistochemistry, Liver Neoplasms, Organ Size/drug effects, Phenobarbital, Proto-Oncogene Proteins c-bcl-2/biosynthesis, Rats, Resveratrol, Sprague-Dawley, Stilbenes/*pharmacology
Lipopolysaccharide supports maintaining the stemness of CD133(+) hepatoma cells through activation of the NF-kappaB/HIF-1alpha pathway.
Tags: *Cancer stem cells, *Lipopolysaccharide, *Plasticity, *Stemness maintenance, *Tumor microenvironment, 2016, AC133 Antigen/genetics/*metabolism, alpha Subunit/genetics/*metabolism, Animals, Antineoplastic Agents – Pharmacodynamics, Antineoplastic Agents/pharmacology, Body Weights and Measures, Cancer letters, Carcinoma, Cell Line, Cell Movement – Drug Effects, Cell Movement/drug effects, Cell Physiology, Cell Physiology – Drug Effects, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Drug Resistance, Gene Expression Regulation, Genes, Genetic Techniques, Han Zhi-Peng, Hepatocellular, Hepatocellular – Drug Therapy, Hepatocellular – Metabolism, Hepatocellular – Pathology, Hepatocellular/drug therapy/genetics/*metabolism/pathology, Humans, Hypoxia-Inducible Factor 1, Inbred BALB C, Jing Ying-Ying, Lai Fo-Bao, Li Rong, Li Xiao-Yong, Lipopolysaccharides – Pharmacodynamics, Lipopolysaccharides/*pharmacology, Liu Jing-Feng, Liu Wen-Ting, Liver Neoplasms, Liver Neoplasms – Drug Therapy, Liver Neoplasms – Metabolism, Liver Neoplasms – Pathology, Liver Neoplasms/drug therapy/genetics/*metabolism/pathology, Male, Mice, NEOMED College of Medicine, Neoplasm, Neoplasm Invasiveness, Neoplastic, Neoplastic Stem Cells/*drug effects/metabolism/pathology, NF-kappa B – Metabolism, NF-kappa B/*metabolism, Nude, Pan Xiao-Rong, Phenotype, Proteins, Proteins – Metabolism, RNA Interference, Shi Rong-Yu, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Stem Cells – Drug Effects, Stem Cells – Metabolism, Stem Cells – Pathology, Time Factors, Transfection, Tumor Burden, Tumor Microenvironment, Wei Li-Xin, Wu Meng-Chao, Yang Xue, Yu Guo-Feng, Zeng Jian-Xing, Zhang Hang-Jie, Zhang Ping, Zhao Qiu-Dong
Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia.
Tags: *Acute lymphoblastic leukemia, *Cancer, *Co-culture model, *Lipids, *Lipoprotein lipase, *Metabolism, 2018, Amides/chemistry/metabolism/pharmacology, Antineoplastic Agents/*chemistry/metabolism/pharmacology, Binding Sites, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Coculture Techniques, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dyslipidemias/complications/metabolism/pathology, Geldenhuys Werner J, Gibson Laura F, Humans, Lipoprotein Lipase/antagonists & inhibitors/*metabolism, Mesenchymal Stem Cells/cytology/metabolism, Molecular Docking Simulation, Nair Rajesh R, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Piktel Debbie, Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications/metabolism/pathology, Protein Binding, Protein Structure, Sadana Prabodh, Serum Albumin/chemistry/metabolism, Tertiary, Tumor
Screening and identification of novel compounds with potential anti-proliferative effects on gallium-resistant lung cancer through an AXL kinase pathway.
Tags: 2014, Alazizi Adnan, Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology, Antitumor, AXL, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Resistance, Drug Screening Assays, Gallium, Gallium-resistance, Gallium/pharmacology, Geldenhuys Werner J, Humans, Lin Li, Liva Sophia, Lung cancer, Lung Neoplasms/drug therapy/*enzymology/*pathology, Molecular Structure, Naphthalenes/chemistry/*pharmacology, NEOMED College of Pharmacy, Neoplasm/drug effects, Oyewumi Moses O, Proto-Oncogene Proteins/*antagonists & inhibitors/metabolism, Pyrazoles/chemistry/*pharmacology, Quinolines/chemistry/*pharmacology, Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism, Structure-Activity Relationship, Tetrazoles/chemistry/*pharmacology, Tumor, Virtual screening
Suppression of inflammatory cascade is implicated in methyl amooranin-mediated inhibition of experimental mammary carcinogenesis.
Tags: 2014, Animals, Anti-Inflammatory Agents/pharmacology, Anticarcinogenic Agents/*pharmacology, Antineoplastic Agents/*pharmacology, Apoptosis/drug effects, Bhatia Deepak, Bishayee Anupam, Breast Neoplasms/*drug therapy/metabolism, breast tumor, Carcinogenesis/*drug effects, Cell Proliferation/drug effects, Chemoprevention/methods, COX-2, Cyclooxygenase 2/metabolism, DMBA, Down-Regulation/drug effects, Experimental/*drug therapy/metabolism, Female, HSP90, HSP90 Heat-Shock Proteins/metabolism, I-kappa B Proteins/metabolism, Inflammation, Inflammation/*drug therapy/metabolism, Mammary Neoplasms, Mandal Animesh, Molecular carcinogenesis, NF-kappa B/metabolism, NF-kappaB, NF-KappaB Inhibitor alpha, oleanane triterpenoid, Oleanolic Acid/*analogs & derivatives/pharmacology, Rats, Sprague-Dawley
Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis.
Tags: 2013, Acute/chemically induced, Animals, Carcinoma, Cell Movement, Cell Proliferation/drug effects, Chen Wei-Dong, Diethylnitrosamine, Forman Barry M, G-Protein-Coupled/*deficiency, Hepatocellular/*chemically induced, Hepatology (Baltimore, Md.), Huang Wendong, Humans, Liver Failure, Liver Neoplasms/*chemically induced, Mice, Phosphorylation, Receptors, STAT3 Transcription Factor/physiology, Tumor Suppressor Proteins/*physiology, Wang Yan-Dong, Yu Donna