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Mitochondrial DNA integrity and function are critical for endothelium-dependent vasodilation in rats with metabolic syndrome

Endothelial dysfunction in diabetes is generally attributed to oxidative stress, but this view is challenged by observations showing antioxidants do not eliminate diabetic vasculopathy. As an alternative to oxidative stress-induced dysfunction, we…

Tags: 2022, Diabetes, endothelial dysfunction, Endothelium, Metabolic syndrome, Mitochondria.

Mechanism of the switch from NO to H2O2 in endothelium-dependent vasodilation in diabetes

Coronary microvascular dysfunction is prevalent among people with diabetes and is correlated with cardiac mortality. Compromised endothelial-dependent dilation (EDD) is an early event in the progression of diabetes, but its mechanisms remain…

Tags: 2022, Coronary Circulation, Coronary dilation, Diabetes, endothelial dysfunction, Microvascular dysfunction.

Poor Medication Adherence in African Americans Is a Matter of Trust.

The purpose of this paper was to explore the lack of medication adherence in the African American patient community. The paper will address myths that many African American patients believe related to type 2 diabetes, hypertension treatment, and …

Tags: 2020, african american, December 2020 List, Department of Internal Medicine, Diabetes, Hall GL, Health disparities, Heath M, Hypertension, Journal Of Racial And Ethnic Health Disparities, journalArticle, medication adherence, NEOMED College of Medicine

An orthopaedist's review of diabetic foot wounds and osteomyelitis.

As the number of patients with diabetes continues to grow, complications of diabetes have likewise increased. Specifically, diabetic foot ulcers have become a massive burden to both the diabetic patient population and national healthcare systems.…

SGLT-2 inhibitors and GLP-1 agonists: First-line therapy for diabetes with established cardiovascular disease.

There is a growing body of evidence that diabetes represents a significant and largely modifiable risk factor for cardiovascular disease (CVD). It is known to markedly increase the risk of CVD-with CVD accounting for 2 of every 3 deaths in …

Am I a Strong Person?

My family and friends (and even my doctor!) think I’m a strong person, but I don’t see it that way. I just do what I need to do to get through each day. Taking care of my family, friends, and sometimes even complete strangers is actually what keeps…

Tags: 2019, Chronic Disease, David Sperling, Department of Family & Community Medicine, Depression, Diabetes, Health Disparities : Weaving A New Understanding Through Case Narratives, Health Psychology, Journal Article, Medical Sociology, Medicine, Medicine & Public Health, NEOMED College of Medicine, November 2019 Update, Premedical Education, Resilience, Social Work

I'm Going to Be OK

“It’s about time you got in here.” I was just a few minutes late getting started for Kathleen’s appointment, so it seemed apparent she was in a hurry. Kathleen sat in a chair next to our examination table. She was restless and her excess body weight…

Tags: 2019, Aultman Hospital, Communication, Department of Family & Community Medicine, Diabetes, Emergency, Emily Godlewski, Health Disparities : Weaving A New Understanding Through Case Narratives, Health Psychology, Journal Article, Medical Sociology, Medicine, Medicine & Public Health, NEOMED College of Medicine, November 2019 Update, Premedical Education, Social Work, Trust

Patient Computer Use To Prompt Doctor Adherence To Diabetes Management Guidelines

Rationale, Aims and Objectives Doctor compliance with diabetic care guidelines is low and may be improved with system-wide changes that include patient involvement. The objective of this study was to determine if patients in an internal medicine…

Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice

Hepatic VLDL overproduction is a characteristic feature of diabetes and an important contributor to diabetic dyslipidemia. Hepatic sortilin 1 (Sort1), a cellular trafficking receptor, is a novel regulator of plasma lipid metabolism and reduces plasma…

Saturated Fatty Acids Activate Erk Signaling To Downregulate Hepatic Sortilin 1 In Obese And Diabetic Mice

Managing foot infections in patients with diabetes

The evaluation of foot infections in patients with diabetes requires a careful physical examination. Wound culture; a probeto-bone test; and imaging studies, such as plain radiography and MRI, should be performed when indicated. Patients with…

Tags: 2006, Diabetes, foot infections, Infections in Medicine, Infectious Diseases, Journal Article, Osteomyelitis, Tan J S, Tan N J

AMPK‐SIRT1‐independent inhibition of ANGPTL3 gene expression is a potential lipid‐lowering mechanism of metformin.

Objectives: Hypertriglyceridaemia enhances cardiovascular disease risk in patients with diabetes. Lipoprotein lipase (LPL) regulates plasma triglyceride levels by hydrolysing chylomicrons and very‐low‐density lipoprotein (VLDL). Metformin, an…

Tags: 2019, angiopoietin‐like 3, Burke Jamie, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Diabetes, dyslipidaemia, Journal of Pharmacy & Pharmacology, Lin Li, Lipoprotein lipase, metformin, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Sadana Prabodh, September 2019 Update, Venkatesh Sahana

Hyperglycemia enhances function and differentiation of adult rat cardiac fibroblasts.

Diabetes is an independent risk factor for cardiovascular disease that can eventually cause cardiomyopathy and heart failure. Cardiac fibroblasts (CF) are the critical mediators of physiological and pathological cardiac remodeling; however, the…

Retinoic acid-related orphan receptor alpha regulates diurnal rhythm and fasting induction of sterol 12alpha-hydroxylase in bile acid synthesis.

Sterol 12alpha-hydroxylase (CYP8B1) is required for cholic acid synthesis and plays a critical role in intestinal cholesterol absorption and pathogenesis of cholesterol gallstone, dyslipidemia, and diabetes. In this study we investigated the…

A comparison of costs associated with screening for gestational diabetes with two-tiered and one-tiered testing protocols.

OBJECTIVE: The Fourth International Workshop on Gestational Diabetes recently suggested that two techniques, a 2-tiered protocol and a 1-tiered protocol, to screen for gestational diabetes mellitus are acceptable alternatives. This study was…

Tags: 2001, American journal of obstetrics and gynecology, Cost-Benefit Analysis, Diabetes, Female, Gestational/*diagnosis/*economics, Glucose Tolerance Test/*economics/*methods, Humans, Lavin B, Lavin J P Jr, Mass Screening/economics, O'Donnell N, Pregnancy, Time Factors

Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.

Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radicals, which can damage mitochondrial DNA. Because mitochondrial DNA plays a key role in the production of ATP necessary for cardiac work, we…

Role of SDF-1:CXCR4 in Impaired Post-Myocardial Infarction Cardiac Repair in Diabetes.

Diabetes is a risk factor for worse outcomes following acute myocardial infarction (AMI). In this study, we tested the hypothesis that SDF-1:CXCR4 expression is compromised in post-AMI in diabetes, and that reversal of this defect can reverse the…

Tags: 2018, Cardiac, Cell therapy, Chilian William, Department of Integrative Medical Sciences, Diabetes, Dong Feng, Forudi Farhad, Kiedrowski Matthew, Mayorga Maritza E, McCallinhart Patricia, NEOMED College of Medicine, Ockunzzi Jeremiah, Penn Marc S, stem cells, Stem cells translational medicine, Stromal derived factor-1, Weber Kristal

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