Browse Items (5 total)
- Tags: Gene Knockdown Techniques
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.
Tags: 2009, Base Sequence, Calcitriol/drug effects/genetics/*physiology, Cell Line, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Cultured, Department of Integrative Medical Sciences, DNA Primers, Drug metabolism and disposition: the biological fate of chemicals, Electrophoretic Mobility Shift Assay, Gene Knockdown Techniques, Genetic/*physiology, Han Shuxin, Hepatocytes/*drug effects/enzymology, Humans, Immunoprecipitation, Lithocholic Acid/pharmacology, Messenger/genetics, NEOMED College of Medicine, Polymerase Chain Reaction, Receptors, RNA, Small Interfering, Transcription, Tumor, Two-Hybrid System Techniques
TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals.
Tags: *Calcium Signaling, *Cell Differentiation, *Mechanotransduction, 2013, Adapala Ravi K, Animals, Cellular, Chilian William M, Department of Integrative Medical Sciences, Extracellular Matrix/metabolism/physiology, Fibroblasts/*physiology, Gene Knockdown Techniques, Journal of molecular and cellular cardiology, Luther Daniel J, Male, Meszaros J Gary, Monoterpenes/pharmacology, Myocardium/cytology, Myofibroblasts/metabolism, NEOMED College of Medicine, Paruchuri Sailaja, Rats, RNA, Small Interfering/genetics, Sprague-Dawley, Thodeti Charles K, Thoppil Roslin J, Transforming Growth Factor beta1/physiology, TRPM Cation Channels/antagonists & inhibitors/metabolism, TRPV Cation Channels/genetics/*metabolism
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Tags: 2009, Adenoviridae/genetics, Animals, Bile Acids and Salts/biosynthesis, Biochimica et biophysica acta, Cell Line, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*antagonists & inhibitors/genetics/metabolism, Department of Integrative Medical Sciences, Dietary Fats/*administration & dosage/*pharmacology, Down-Regulation/drug effects, Enzymologic/drug effects, Feeding Behavior/*drug effects, Forkhead Box Protein O1, Forkhead Transcription Factors/genetics/*metabolism, Gene Expression Regulation, Gene Knockdown Techniques, Gene Transfer Techniques, Hepatocytes/drug effects/*enzymology, Humans, Inbred C57BL, Insulin Resistance, Insulin/metabolism, Lee Yoon-Kwang, Li Tiangang, Ma Huiyan, Male, Messenger/genetics/metabolism, Mice, Moore David D, NEOMED College of Medicine, Park Young Joo, RNA, RNA Interference/drug effects, Strom Stephen, Tumor
Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.
Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao
MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein-induced protein 1 expression in interleukin-1beta-stimulated human chondrocytes.
Tags: 2015, Academic Medical Centers, Aged, Arthritis & rheumatology (Hoboken, N.J.), Articular/drug effects/*metabolism, Cartilage, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism, Cultured, Department of Anatomy & Neurobiology, Enzyme-Linked Immunosorbent Assay, Funding Source, Gene Knockdown Techniques, Haqqi Tariq M, Haseeb Abdul, Hip/*genetics/metabolism, Human, Humans, Immunoblotting – Utilization, Immunoprecipitation, Interleukin-1beta/pharmacology, Interleukin-6/*genetics/metabolism, Interleukins – Physiology, Makki Mohammad S, Messenger/drug effects/*metabolism, MicroRNAs/drug effects/*genetics/metabolism, Middle Aged, NEOMED College of Medicine, Ohio, Osteoarthritis, Osteoarthritis – Complications, Osteoarthritis – Physiopathology, Reverse Transcriptase Polymerase Chain Reaction, Ribonucleases/drug effects/*genetics/metabolism, RNA, T-Tests, Transcription Factors/drug effects/*genetics/metabolism