Browse Items · NEOMED Bibliography Database

Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor.

Long-chain acyl-CoA synthetase 1 (ACSL1) plays a pivotal role in fatty acid betaoxidation in heart, adipose tissue and skeletal muscle. However, key functions of ACSL1 in the liver remain largely unknown. We investigated acute effects of hepatic…

Tags: *Farnesoid X receptor, 2019, ACSL1, Bile acid synthesis, Biochimica et biophysica acta. Molecular and cell biology of lipids, Department of Integrative Medical Sciences, Dong Bin, Gene Expression Profiling, Hypercholesterolemia, Liu Jingwen, NEOMED College of Medicine, Obeticholic acid, Singh Amar Bahadur, Xu Yanyong, Zhang Yanqiao

Apocynum Tablet Protects against Cardiac Hypertrophy via Inhibiting AKT and ERK1/2 Phosphorylation after Pressure Overload.

Six stroma-based RNA markers diagnostic for prostate cancer in European-Americans validated at the RNA and protein levels in patients in China.

We previously analyzed human prostate tissue containing stroma near to tumor and from cancer-negative tissues of volunteers. Over 100 candidate gene expression differences were identified and used to develop a classifier that could detect nearby…

Can we approach zero relapse in breast cancer?

Adjuvant hormonal therapy and adjuvant chemotherapy have contributed significantly to the falling rates of breast cancer mortality. The introduction of taxanes and aromatase inhibitors in the adjuvant setting represents recent important improvements.…

Tags: 2005, Adjuvant, Antineoplastic Agents, Aromatase Inhibitors/therapeutic use, Breast Neoplasms/mortality/pathology/*prevention & control/*therapy, Chemotherapy, Disease-Free Survival, Female, Gene Expression Profiling, Hormonal/*therapeutic use, Humans, Lymph Nodes/pathology, Mamounas Eleftherios P, Neoadjuvant Therapy, Prognosis, Recurrence, The oncologist

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures.

Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these cells undergo following seizure induction is not well understood. As such, we utilized RNAseq…

Induction of vascular progenitor cells from endothelial cells stimulates coronary collateral growth.

RATIONALE: A well-developed coronary collateral circulation improves the morbidity and mortality of patients following an acute coronary occlusion. Although regenerative medicine has great potential in stimulating vascular growth in the heart, to…

Tags: *Collateral Circulation, *Coronary Circulation, 2012, Animal, Animals, Bailey Erin, Biomarkers/metabolism, Cell Differentiation, Cell Lineage, Cells, Chilian William M, Circulation research, Coronary Occlusion/genetics/metabolism/pathology/physiopathology/*surgery, Coronary Vessels/metabolism/pathology/*physiopathology, Cultured, Delucia Angelo, Department of Integrative Medical Sciences, Developmental, Disease Models, Endothelial Cells/metabolism/pathology/*transplantation, Enrick Molly, Epigenesis, Gene Expression Profiling, Gene Expression Regulation, Genetic, Guarini Giacinta, Induced Pluripotent Stem Cells/metabolism/*transplantation, Kolz Christopher L, Mice, Muscle, Myocytes, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Physiologic, Pung Yuh Fen, Rats, Regenerative Medicine/methods, Regional Blood Flow, Reverse Transcriptase Polymerase Chain Reaction, SCID, Smooth, Smooth Muscle/metabolism/pathology/*transplantation, Sprague-Dawley, Stevanov Kelly, Teratoma/metabolism/pathology, Time Factors, Transcription Factors/genetics/metabolism, Transduction, Vascular/metabolism/pathology/*physiopathology, Yin Liya

Development of bone and cartilage in tissue-engineered human middle phalanx models.

Human middle phalanges were tissue-engineered with midshaft scaffolds of poly(L-lactide-epsilon-caprolactone) [P(LA-CL)], hydroxyapatite-P(LA-CL), or beta-tricalcium phosphate-P(LA-CL) and end plate scaffolds of bovine chondrocyte-seeded polyglycolic…

Tags: *Models, 2009, Aggrecans/genetics/metabolism, Animals, Biological, Bone Development/drug effects/*physiology, Calcium Phosphates/pharmacology, Cartilage/cytology/drug effects/*growth & development, Cattle, Chondrocytes/cytology/drug effects/metabolism, Collagen Type II/genetics/metabolism, Durapatite/pharmacology, Electron, Enjo Mitsuhiro, Experimental, Finger Phalanges/cytology/diagnostic imaging/drug effects/*physiology, Gene Expression Profiling, Gene Expression Regulation/drug effects, Humans, Implants, Integrin-Binding Sialoprotein, Isogai Noritaka, Jacquet Robin, Landis William J, Lowder Elizabeth, Mice, Microscopy, Paraffin Embedding, Periosteum/cytology/drug effects, Polyesters/pharmacology, Radiography, Scanning, Sialoglycoproteins/genetics/metabolism, Tissue engineering. Part A, Tissue Engineering/*methods, Tissue Scaffolds/chemistry, Wada Yoshitaka

LPS-TLR4 Pathway Mediates Ductular Cell Expansion in Alcoholic Hepatitis.

Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease for which there are no effective therapies. Patients with AH show impaired hepatocyte proliferation, expansion of inefficient ductular cells and high lipopolysaccharide (LPS)…

Tags: 2016, Affo Silvia, Alcoholic/*immunology, Altamirano Jose, Animals, Arroyo Vicente, Bataller Ramon, Caballeria Juan, Cell Proliferation, Cells, Chen Jiegen, Collagen/genetics/metabolism, Common/*pathology, Crews Fulton, Cultured, Department of Pharmaceutical Sciences, Dumitru Raluca, Female, Gene Expression Profiling, Gene Expression Regulation, Gines Pere, Hepatic Duct, Hepatitis, Hepatocytes/*metabolism/pathology, Humans, Inbred BALB C, Keratins, Knockout, Lipopolysaccharides/metabolism, Lozano Juan Jose, Male, Matsushita Hiroshi, Mice, Middle Aged, Morales-Ibanez Oriol, NEOMED College of Pharmacy, Odena Gemma, Rautou Pierre-Emmanuel, Rodrigo-Torres Daniel, Sancho-Bru Pau, Scientific reports, Seki Ekihiro, Signal Transduction, Toll-Like Receptor 4/genetics/*metabolism, Type I/genetics/*metabolism, Valla Dominique, You Min, Zou Jian

Curated compendium of human transcriptional biomarker data.

One important use of genome-wide transcriptional profiles is to identify relationships between transcription levels and patient outcomes. These translational insights can guide the development of biomarkers for clinical application. Data from…

Tags: *Biomarkers, *Transcription, 2018, Bell Avery, Bischoff Anna I, Databases, Disease/genetics, Gene Expression Profiling, Genetic, Golightly Nathan P, Hollingsworth Parker D, Humans, Piccolo Stephen R, Scientific data

Identification of a novel function of hepatic long-chain acyl-CoA synthetase-1 (ACSL1) in bile acid synthesis and its regulation by bile acid-activated farnesoid X receptor.

Long-chain acyl-CoA synthetase 1 (ACSL1) plays a pivotal role in fatty acid betaoxidation in heart, adipose tissue and skeletal muscle. However, key functions of ACSL1 in the liver remain largely unknown. We investigated acute effects of hepatic…

Tags: 2019, ACSL1, Bile acid synthesis, Biochimica et biophysica acta. Molecular and cell biology of lipids, Department of Integrative Medical Sciences, Dong Bin, Farnesoid X receptor, Gene Expression Profiling, Hypercholesterolemia, Liu Jingwen, NEOMED College of Medicine, Obeticholic acid, Singh Amar Bahadur, Xu Yanyong, Zhang Yanqiao

Identification of plasma microRNA expression profile in radiographic axial spondyloarthritis-a pilot study.

At present, there are no studies that have established a microRNA (miRNA)-based signature profile in patients with radiographic axial spondyloarthritis (rad-axial SpA), and we hypothesized that these patients may have aberrantly expressed circulating…

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