Browse Items (11 total)

Cardiac remodelling is a key risk factor for the development of heart failure in the chronic phase following myocardial infarction. Our previous studies have shown an anti-remodelling role of ACE2 (angiotensin-converting enzyme 2) in vivo during…

Objective: To assess global and splanchnic blood flow and oxygen transport in patients with sepsis with and without norepinephrine treatment. Design: Prospective, clinical study. Setting: University hospital intensive care unit. Patients: A…

The common frog, Rana temporaria, overwinters under the ice of frozen lakes and ponds, during which time metabolic, respiratory and behavioural adjustments act in concert to conserve metabolic fuels by promoting aerobic metabolism. Animal behaviour…

At the low temperatures of the overwintering environment of the frog Rana temporaria, small changes in ambient temperature have large effects on metabolism and behaviour, especially since Q(10) values are often greatly elevated in the cold. How the…

Amphibians overwintering in ice-covered aquatic environments encounter levels of hypoxia that present significant challenges to the maintenance of aerobic metabolism. Earlier laboratory experiments showed that cold-submerged frogs will seek out lower…

As part of a broader effort to identify postreceptor signal regulators involved in specific diseases or organ adaptation, we used an expression cloning system in Saccharomyces cerevisiae to screen cDNA libraries from rat ischemic myocardium, human…

It has recently become clear that obstructive sleep apnea (OSA) is an independent risk factor for the development of metabolic syndrome, a disorder of defective energy storage and use. Several mechanisms have been proposed to explain this finding,…
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