For decades coronary macrovascular atherosclerosis has been considered the principal manifestation of coronary heart disease, with most of our effort dedicated to identifying and removal of coronary stenosis. However, growing body of literature…
The regulation of the coronary circulation is a complex paradigm in which many inputs that influence vasomotor tone have to be integrated to provide the coronary vasomotor adjustments to cardiac metabolism and to perfusion pressure. We hypothesized…
Amphibians overwintering in ice-covered aquatic environments encounter levels of hypoxia that present significant challenges to the maintenance of aerobic metabolism. Earlier laboratory experiments showed that cold-submerged frogs will seek out lower…
Allen's Rule documents a century-old biological observation that strong positive correlations exist among latitude, ambient temperature, and limb length in mammals. Although genetic selection for thermoregulatory adaptation is frequently presumed to…
Objective. The purpose of this study was to determine the accuracy of prenatal cardiac diagnosis, prognosis, and outcome of totally anomalous pulmonary venous connection (TAPVC) and to determine echocardiographic clues in the prenatal diagnosis of…
Prenatal diagnosis of partial anomalous pulmonary venous connection (PAPVC) is rare. We describe a case in which the diagnosis was made at 24 weeks' gestation. The fetus had a double-outlet right ventricle, mitral atresia, a subaortic ventricular…
We investigated the importance of changes in intracellular Ca2+ concentration ([Ca2+](i)) for amiloride-sensitive alveolar fluid clearance (AFC) in late-gestational guinea pigs. Fetal guinea pigs of 61, 68, and 69 days (term) gestation were…