Overexpression of beta-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas.

Title

Overexpression of beta-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas.

Creator

Wang Hai; Wang Haiyan; Makki Mohammad Shahidul; Wen Juanjuan; Dai Yingqing; Shi Qunli; Liu Qi; Zhou Xiaojun; Wang Jiandong

Publisher

International journal of clinical and experimental pathology

Date

2014
1905-07

Description

UNLABELLED: Ovarian serous cancer is the most common subtype of epithelial ovarian cancer, and is the leading cause of death from gynecologic cancer. There is an important need for exploration of diagnostic and prognostic markers for this disease. beta-catenin and cyclinD1 play central roles in the tumorigenesis for certain cancers. The role of beta-catenin and cyclinD1 in diagnosis and prognosis of ovarian serous carcinoma is uncertain. In the present study, the expression of beta-catenin and cyclinD1 was examined in 60 ovarian serous carcinomas patients with immunohistochemical staining. The relationship between expression of beta-catenin and cyclinD1 and FIGO stage, pathological grade was analyzed. Kaplan-Meier survival function was used to analyze the prognosis. Overexpression of beta-catenin is more often detected in patients with FIGO stage III and IV than in those with stage I, and II (P=0.003). No significant relationship was found between expression of beta-catenin and pathological grade (P=0.817). Positive expression of beta-catenin related to lower survival rate (P=0.034). The expression of cyclinD1 had no relationship with FIGO stage (P=0.829). Overexpression of cyclinD1 was positively to pathological grade (P=0.017) and survival rate (P=0.009). There is a significantly positive relationship between expression of beta-catenin and cyclinD1 (P=0.014). No statistical significance was found between expression of beta-catenin and cyclinD1 and other pathological parameters. CONCLUSIONS: Expression of beta-catenin and cyclinD1 may be used as predict markers for poor prognosis.

Subject

Adult; Female; Humans; Middle Aged; Aged; Young Adult; Immunohistochemistry; Neoplasm Staging; Prognosis; Kaplan-Meier Estimate; Up-Regulation; Biomarkers; beta-catenin; beta Catenin/analysis/*biosynthesis; Cyclin D1/analysis/*biosynthesis; cyclinD1; Ovarian Neoplasms/*metabolism/mortality/pathology; ovarian serous carcinoma; prognosis; Cystadenocarcinoma; Serous/*metabolism/mortality/pathology; Tumor/*analysis

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

264–271

Issue

1

Volume

7

Citation

Wang Hai; Wang Haiyan; Makki Mohammad Shahidul; Wen Juanjuan; Dai Yingqing; Shi Qunli; Liu Qi; Zhou Xiaojun; Wang Jiandong, “Overexpression of beta-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas.,” NEOMED Bibliography Database, accessed September 27, 2021, https://neomed.omeka.net/items/show/5687.

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