Browse Items (19 total)
- Tags: Neurodegeneration
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Ngp1-01, A Multi-targeted Polycyclic Cage Amine, Attenuates Brain Endothelial Cell Death In Iron Overload Conditions
Tags: 2012, activator, Allen D D, barrier, Brain research, Calcium Channels, channels provide, Geldenhuys W J, intracerebral hemorrhage, Iron-overload, Jones-Higgins M R, Journal Article or Conference Abstract Publication, Lockman J A, Neurodegeneration, neurodegenerative disorders, Neuroprotection, Neurosciences & Neurology, nimodipine, parkinsons-disease, Patrick J D, Permeability, rat-brain, toxicity, transport, Van der Schyf C J, Vascular endothelial cells, Voltage-gated calcium channel
Exome Sequencing Reveals A Novel Wdr45 Frameshift Mutation And Inherited Polr3a Heterozygous Variants In A Female With A Complex Phenotype And Mixed Brain Mri Findings
Tags: 2015, 4H syndrome, accumulation, atp13a2 mutations, clinical spectrum, Demyelinating disease, diabetes-mellitus, European journal of medical genetics, gene, Genetics & Heredity, hallervorden-spatz-syndrome, hypogonadism, iron, Journal Article or Conference Abstract Publication, Khalifa M, Leukodystrophy, Naffaa L, NBIA, Neurodegeneration, POLR3A, spastic paraplegia spg35, WDR45, Whole Exome Sequencing
Molecular Insights Into Human Monoamine Oxidase B Inhibition By The Glitazone Antidiabetes Drugs
Tags: 2012, Acs Medicinal Chemistry Letters, Aldeco M, Antidiabetes drug, Binda C, Chemistry, Drug Design, Edmondson D E, gamma agonist pioglitazone, Geldenhuys W J, high-level expression, Journal Article or Conference Abstract Publication, lsd1, Mattevi A, monoamine oxidase, Mouse model, Neurodegeneration, Neuroprotection, parkinsons-disease, Pharmacology & Pharmacy, pichia-pastoris, pioglitazone, Rosiglitazone, Tortorici M
Brain Iron Toxicity: Differential Responses Of Astrocytes, Neurons, And Endothelial Cells
Tags: 2007, Allen D D, Astrocyte, Biochemistry & Molecular Biology, brain iron toxicity, central-nervous-system, cerebrospinal-fluid, endothelial cell, experimental intracerebral hemorrhage, Gaasch J A, Geldenhuys W J, Lockman P R, low-molecular-weight, multifunctional neuroprotective drugs, Neurochemical Research, Neurodegeneration, Neuron, Neurosciences & Neurology, Oxidative Stress, parkinsons-disease, protein messenger-rna, receptor-mediated transcytosis, toxic mechanisms, transferrin receptor, Van der Schyf C J
Voltage-gated Calcium Channels Provide An Alternate Route For Iron Uptake In Neuronal Cell Cultures
Tags: 2007, Allen D D, alzheimer-disease, alzheimers-disease, Biochemistry & Molecular Biology, fpl-64176, Gaasch J A, Geldenhuys W J, iron-overload toxicity, Lockman P R, Metabolism, mouse-brain, nerve growth-factor, neuroblastoma-cells, Neurochemical Research, Neurodegeneration, Neurosciences & Neurology, nimodipine, parkinsons-disease, redox-active iron, SUBSTANTIA nigra, transferrin receptor, Van der Schyf C J, voltage-gated calcium channels
Estrogen, Testosterone, And Methamphetamine Toxicity
Tags: 17-beta-estradiol, 2006, c57/b1 mice, Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity: Cocaine, Ghb, and Substituted Amphetamines, differences, Dluzen D E, Female, gonadal steroids, inhibition, McDermott J L, mptp-induced neurotoxicity, Neurodegeneration, Neuroprotection, Neurotoxicity, nigrostriatal, nigrostriatal dopaminergic system, parkinsons-disease, sex, sexual differences, striatum, Tamoxifen
Developmental And Genetic Influences Upon Gender Differences In Methamphetamine-induced Nigrostriatal Dopaminergic Neurotoxicity
Tags: 2004, bdnf mutant mice, Brain, brain-derived neurotrophic factor (BDNF), Current Status of Drug Dependence / Abuse Studies: Cellular and Molecular Mechanisms of Drugs of Abuse and Neurotoxicity, differentiation, Dluzen D E, Dopamine, estrogen, female mice, gonadal-hormones, McDermott J L, messenger-rna, mptp-induced neurotoxicity, Neurodegeneration, Neuroprotection, neurotrophic factor, parkinsons-disease, sexual, sexual differences, Testosterone, ventral mesencephalon
Abnormal Metal Levels In The Primary Visual Pathway Of The Dba/2j Mouse Model Of Glaucoma
Tags: 2014, alzheimers-disease, amyloid-beta, aqueous-humor, Biochemistry & Molecular Biology, Biometals, Braymer J J, Crish S D, Deb A, Dengler-Crish C M, Department of Pharmaceutical Sciences, DeToma A S, ganglion-cell degeneration, gene-expression, Glaucoma, ICP-MS, iron, Lim M H, Microarray Analysis, NEOMED College of Pharmacy, Neurodegeneration, Penner-Hahn J E, retina, superior colliculus, synapse, Van der Schyf C J
Molecular Insights Into Human Monoamine Oxidase B Inhibition By The Glitazone Antidiabetes Drugs
Tags: 2012, Acs Medicinal Chemistry Letters, Aldeco M, Antidiabetes drug, Binda C, Chemistry, Drug Design, Edmondson D E, gamma agonist pioglitazone, Geldenhuys W J, high-level expression, lsd1, Mattevi A, monoamine oxidase, Mouse model, Neurodegeneration, Neuroprotection, parkinsons-disease, Pharmacology & Pharmacy, pichia-pastoris, pioglitazone, Rosiglitazone, Tortorici M
Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy
Tags: 2013, activated protein-kinase, alzheimers-disease brain, amyotrophic-lateral-sclerosis, Axonopathy, Calkins D J, Crish S D, Dapper J D, Death, Department of Pharmaceutical Sciences, experimental glaucoma, ganglion-cell neurons, Glaucoma, Heat shock protein, Journal Article or Conference Abstract Publication, Mouse model, NEOMED College of Pharmacy, Neurobiology of disease, Neurodegeneration, Neurosciences & Neurology, Ocular Hypertension, p38 MAPK, Pang I H, rat retina, Retinal ganglion cell, Up-Regulation
Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma
Tags: 2015, Aging, axonal-transport, axoplasmic-transport, Crish S D, Cytokines, Denger-Crish C M, Department of Pharmaceutical Sciences, fibroblast-growth-factor, gene-expression, Glaucoma, Immunology, Inflammation, Inman D M, Intraocular Pressure, Journal Article, Journal of neuroinflammation, necrosis-factor-alpha, NEOMED College of Pharmacy, Neurodegeneration, Neurosciences & Neurology, Ocular Hypertension, optic-nerve head, retinal ganglion-cells, Smith M A, TNF-alpha, Wilson G N
Dissecting the determinants of neuropathogenesis of the murine oncornaviruses
Tags: 1998, c rna virus, central-nervous-system, endothelial-cell tropism, induced spongiform, Infection, Journal Article, leukemia-virus, Lynch W P, motor neuron disease, Neurodegeneration, neurological disease, neurotropic retrovirus, Portis J L, temperature-sensitive mutant, Virology, wild mouse retrovirus
Cross-Talk Between Stem Cells and the Dysfunctional Brain is Facilitated by Manipulating the Niche: Evidence from an Adhesion Molecule
Tags: 2009, adhesion molecule, Aging, aging and age-related diseases, Astrocytes, axonal regeneration, Biotechnology & Applied Microbiology, Cell Biology, central-nervous-system, chaperone effect, differentiation, Dopamine, extracellular, functional recovery, Hematology, Journal Article, L1, Lynch W P, matrix, migration, model, molecules, motor-neurons, mouse, MPTP, Neural stem cells, Neurodegeneration, Neuroprotection, neurotrophic factors, niche, oncology, Ourednik J, Ourednik V, Oxidative Stress, parkinsons-disease, protect neurons, recognition, Schachner M, Snyder E Y, spinal-cord-injury, stem cells, Transplantation, Xu Y F, Zhang Y
Neurotoxicity of pesticides.
Tags: 2019, Acta Neuropathologica, activity, cell-culture, Department of Pharmaceutical Sciences, Developmental, Dichlorodiphenyltrichloroethane, Dieldrin, Endosulfan, exposure, Fitsanakis Vanessa, Fungicide, Glyphosate, glyphosate-based herbicide, induced oxidative stress, IPSC, Kanthasamy Anumantha G, Microelectrode array, Mitochondrial Complex I, mitochondrial complex-i, NEOMED College of Pharmacy, Neurodegeneration, neuronal network, Neurosciences & Neurology, Neurotoxicity, nigrostriatal dopamine system, Organochlorine, Organophosphate, Paraquat, parkinsons-disease, Pathology, Pesticide, Pyrethroid, pyrethroid insecticides, Pyridaben, reproduces features, Richardson Jason R, Rotenone, September 2019 Update, Westerink Remco H S, Zebrafish
Neurotoxicity of pesticides
Tags: 2019, Acta Neuropathologica, Department of Pharmaceutical Sciences, Dichlorodiphenyltrichloroethane, Dieldrin, Endosulfan, Fitsanakis Vanessa, Fungicide, Glyphosate, IPSC, June 2019 Update, Kanthasamy Anumantha G, Microelectrode array, Mitochondrial Complex I, NEOMED College of Pharmacy, Neurodegeneration, Neurotoxicity, Organochlorine, Organophosphate, Paraquat, Pesticide, Pyrethroid, Pyridaben, Richardson Jason R, Rotenone, Westerink Remco H S, Zebrafish
Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma.
Tags: 2014, Axonal Transport, Axonopathy, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Frontiers in neuroscience, Glaucoma, Inman Denise M, NEOMED College of Medicine, NEOMED College of Pharmacy, Neurodegeneration, ocular, optic nerve, Smith Matthew A, superior colliculi, vision disorders, Wilson Gina N, Young Jesse W
Glycoprotein NMB: an Emerging Role in Neurodegenerative Disease.
Tags: 2018, Animals, Budge Kevin M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, GPNMB, Humans, Immune System/metabolism, Membrane Glycoproteins/chemistry/*metabolism, Molecular neurobiology, Neal Matthew L, NEOMED College of Medicine, NEOMED College of Pharmacy, Nerve Degeneration/pathology, Neurodegeneration, Neurodegenerative Diseases/*metabolism/therapy, Neuroinflammation, Neuroprotection, Richardson Jason R, Safadi Fayez F
Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers.
Tags: 2016, Alicyclic/chemical synthesis/*chemistry/pharmacology, Amines/chemical synthesis/*chemistry/pharmacology, Animals, Apoptosis/drug effects, Archiv der Pharmazie, Calcium Channel Blockers/chemical synthesis/*chemistry/pharmacology, Calcium Channels, Calcium/*metabolism, Cell Survival/drug effects, Domingo Olwen C, Geldenhuys Werner J, Hydrocarbons, Hydrogen Peroxide/pharmacology, L-Lactate Dehydrogenase/metabolism, L-type calcium channel (LTCC) blockers, L-Type/*metabolism, Malan Sarel F, Multifunctional drugs, Neurodegeneration, PC12 Cells, Pentacycloundecylamine, Quinones/chemical synthesis/*chemistry/pharmacology, Rats, Structure-Activity Relationship, Triquinylamine, Van der Schyf Cornelis J, Young Lois-May