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Tags: Interleukin-6/genetics/metabolism

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MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the

OBJECTIVES: Chronic-plus-binge ethanol feeding activates neutrophils and exacerbates liver injury in mice. This study investigates how recent excessive drinking affects peripheral neutrophils and liver injury in alcoholics, and how miR-223, one of…

Tags: *CYTOKINES, *ETHANOL, *FATTY LIVER, *Inflammation, *LEUKOCYTES, 2017, Adult, Alanine Transaminase/blood, Alcoholic/genetics/*metabolism/pathology, Alcoholism/*blood/complications, Animals, Aspartate Aminotransferases/blood, Bilirubin/blood, Binge Drinking/*blood/complications, Cai Yan, Cao Haixia, Case-Control Studies, Central Nervous System Depressants/administration & dosage, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Down-Regulation, Ethanol/administration & dosage, Female, Feng Dechun, Gao Bin, Gao Yanhang, Gao Yueqiu, Gut, He Yong, Humans, Inbred C57BL, Interleukin-6/genetics/metabolism, Li Man, Liangpunsakul Suthat, Liver Diseases, Male, Mice, MicroRNAs/*blood/*genetics, Middle Aged, NADPH Oxidases/genetics/metabolism, NEOMED College of Medicine, NEOMED College of Pharmacy, Neutrophils/*metabolism, Ramirez Teresa, Reactive Oxygen Species/metabolism, Ross Ruth A, Up-Regulation, Xu Ming-Jiang, Young Adult, Zhang Ping, Zhou Zhou

A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1beta-induced activation of AP-1 in human OA chondrocytes.

Osteoarthritis (OA) is a common joint disorder with varying degrees of inflammation and sustained oxidative stress. The root extract of Scutellaria baicalensis (SBE) has been used for the treatment of inflammatory and other diseases. Here, we…

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