Modulatory effects of testosterone on

Title

Modulatory effects of testosterone on

Creator

Dluzen D; Jain R; Liu B

Publisher

Journal of neurochemistry

Date

1994
1994-01

Description

In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either empty Silastic capsules or capsules containing testosterone and subsequently treated with MPTP. A small area of the corpus striatum was removed for determination of dopamine (DA) content, whereas the remainder was superfused and used to measure L-DOPA (5 microM)-evoked DA release. In animals treated with MPTP, L-DOPA-evoked DA release was reduced significantly in CD-1 mice, but not in C57/B1 mice, treated with testosterone. No differences in L-DOPA-stimulated DA release between MPTP-versus vehicle-treated mice was observed in either the CD-1 or C57/B1 mice receiving empty Silastic capsules. Corpus striatum DA contents were more severely depleted in the MPTP-sensitive C57/B1 versus the CD-1 mouse strain irrespective of hormone treatment. These results confirm previous results demonstrating differences in these two mouse strains in response to the neurotoxic effects of MPTP upon corpus striatum DA content. More interestingly, they show an important differential modulatory effect of testosterone upon

Subject

Male; Animals; Mice; Species Specificity; Reference Values; Dopamine/*metabolism; Corpus Striatum/drug effects/*metabolism; Orchiectomy; Drug Implants; Testosterone/administration & dosage/*pharmacology; Neurotoxins/antagonists & inhibitors/*toxicity; *MPTP Poisoning; Levodopa/pharmacology; Inbred Strains; Inbred C57BL; 3; 1-Methyl-4-phenyl-1; 2; Parkinson Disease; 6-tetrahydropyridine/antagonists & inhibitors; Secondary/chemically induced/*physiopathology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

94–101

Issue

1

Volume

62

Citation

Dluzen D; Jain R; Liu B, “Modulatory effects of testosterone on,” NEOMED Bibliography Database, accessed June 19, 2021, https://neomed.omeka.net/items/show/5377.

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