The effects of intranasal infusion of

Title

The effects of intranasal infusion of

Creator

Dluzen D E; Kefalas G

Publisher

Brain research

Date

1996
1996-11

Description

Male C57/B1 mice received bilateral intranasal infusions of saline, MPTP or an intraperitoneal injection of MPTP. Infusions were performed using a peristaltic pump at a setting of 100 microliters/min. The MPTP, diluted in saline at concentrations of 2 mg/ml, was infused over 15 (0.1 mg) or 30 (0.2 mg) s, while the saline (control) infusions were of 30 s duration. In a separate group of mice, MPTP was injected via the intraperitoneal route at a dose equivalent to that of the 30-s intranasal concentration (0.2 mg). At 7 days post-treatment, catecholamine concentrations were determined from the olfactory bulbs and corpus striatum. Concentrations of norepinephrine within both the olfactory bulbs and corpus striatum of mice receiving the intranasal infusion of MPTP were significantly lower than those of the intranasal saline and intraperitoneal

Subject

Male; Animals; Mice; Corpus Striatum/drug effects/*metabolism; Dopamine/metabolism; Olfactory Bulb/drug effects/*metabolism; Norepinephrine/metabolism; Injections; Catecholamines/*metabolism; Dopamine Agents/administration & dosage/*pharmacology; Inbred C57BL; 3; Intraperitoneal; 1-Methyl-4-phenyl-1; 2; Administration; Intranasal; 6-tetrahydropyridine/administration & dosage/*pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

215–219

Issue

1

Volume

741

Citation

Dluzen D E; Kefalas G, “The effects of intranasal infusion of,” NEOMED Bibliography Database, accessed May 15, 2021, https://neomed.omeka.net/items/show/5373.

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