Outcomes with drug-coated balloons in small-vessel coronary artery disease.

Title

Outcomes with drug-coated balloons in small-vessel coronary artery disease.

Creator

Megaly M; Rofael M; Saad M; Rezq A; Kohl LP; Kalra A; Shishehbor M; Soukas P; Abbott JD; Brilakis ES

Publisher

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Date

2019
2019-04-01

Description

BACKGROUND: Percutaneous coronary intervention (PCI) of small-vessel coronary artery disease (SVD) is associated with increased risk of restenosis. The use of drug-coated balloons (DCBs) in SVD has received limited study. OBJECTIVES: To assess the outcomes of DCB in the treatment of SVD compared with the standard of care. METHODS: We performed a meta-analysis of all studies published between January 2000 and September 2018 reporting the outcomes of DCB versus other modalities in the treatment of de novo SVD. RESULTS: Seven studies with 1,824 patients (1,938 lesions) were included (four randomized controlled trials and three observational studies). During a mean follow-up of 14.5 ± 10 months, DCBs were associated with a similar risk of target lesion revascularization (TLR) (OR: 0.99, 95% CI: 0.54, 1.84, P = 97) and major adverse cardiovascular events (MACE) (OR: 0.86, 95% CI: 0.51, 1.45, P = 0.57) compared with drug-eluting stents (DES). During a mean follow-up of 7 ± 1.5 months, DCBs were associated with a significantly lower risk of TLR (OR: 0.19, 95% CI 0.04-0.88, P = 0.03) and binary restenosis (OR: 0.17, 95% CI 0.08-0.37, P = <0.00001) compared with noncoated balloon angioplasty. CONCLUSION: The use of DCBs in SVD is associated with comparable outcomes when compared with DES and favorable outcomes when compared with balloon angioplasty.

Subject

Female; Humans; Male; Aged; Middle Aged; Treatment Outcome; Risk Factors; Risk Assessment; Randomized Controlled Trials as Topic; Cardiac Catheters; Coated Materials Biocompatible; drug-coated balloons; drug-eluting balloons; Drug-Eluting Stents; small-vessel disease coronary disease; Angioplasty Balloon Coronary/adverse effects/instrumentation/mortality; Cardiovascular Agents/administration & dosage/adverse effects; Coronary Artery Disease/diagnostic imaging/mortality/therapy; Coronary Restenosis/epidemiology; Observational Studies as Topic

Identifier

PMID: 30489687

Rights

© 2018 Wiley Periodicals, Inc.

Format

journalArticle

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Pages

E277-E286

Issue

5

Volume

93

ISSN

1522-726X

NEOMED College

NEOMED College of Medicine

NEOMED Department

Department of Internal Medicine

Update Year & Number

June2020SubmittedList

Affiliated Hospital

Cleveland Clinic Akron General Hospital

Citation

Megaly M; Rofael M; Saad M; Rezq A; Kohl LP; Kalra A; Shishehbor M; Soukas P; Abbott JD; Brilakis ES, “Outcomes with drug-coated balloons in small-vessel coronary artery disease.,” NEOMED Bibliography Database, accessed December 1, 2021, https://neomed.omeka.net/items/show/11196.

Social Bookmarking