Syringocystadenoma papilliferum of the male breast

Title

Syringocystadenoma papilliferum of the male breast

Creator

Nowak M; Pathan A; Fatteh S; Lopez J

Publisher

American Journal of Dermatopathology

Date

1998
1998-08

Description

A 39-year-old man presented with a 2-cm, mildly tender mass in the right breast of many years' duration. Microscopic examination showed a syringocystadenoma papilliferum. Because of its location in the breast, we studied the lesion for immunohistochemical markers for apocrine differentiation. Gross cystic disease fluid protein-15 (GCDFP-15) staining yielded negative results in the cystic luminal epithelial cells, whereas GCDFP-15 and lysozyme staining yielded strongly positive results in the epithelial cells of adjacent tubular apocrine glands. Focal strong lysozyme positivity was seen in the cystic luminal epithelial cells. These findings do not support apocrine differentiation in this case, despite its location in the breast, an organ rich in specialized apocrine (lactiferous) elands. To our knowledge, this represents the first reported case of syringocystadenoma papilliferum of the male breast. We present the clinical and pathologic features of this unusual case and a review of the literature.

Subject

apocrine; Breast; Dermatology; differentiation; eccrine differentiation; GCDFP-15; lysozyme; male; plasma cell infiltrate; syringocystadenoma papilliferum; tumors

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

422-424

Issue

4

Volume

20

Citation

Nowak M; Pathan A; Fatteh S; Lopez J, “Syringocystadenoma papilliferum of the male breast,” NEOMED Bibliography Database, accessed June 18, 2021, https://neomed.omeka.net/items/show/6664.

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