Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions.

Title

Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions.

Creator

Wehrung Daniel; Geldenhuys Werner J; Oyewumi Moses O

Publisher

Colloids and surfaces. B, Biointerfaces

Date

2012
2012-06

Description

The main objective of the study is to investigate the efficacy of Gelucire 44/14 (gelucire) in facilitating formation of cetyl alcohol (CA)-based nanoparticle (NP) and to assess the effects on key NP properties and functions. NPs from oil-in-water nanoemulsion precursors were prepared using binary mixtures of CA and gelucire (CA/gelucire) containing gelucire at 0, 25, 50 and 75% (w/w). The sizes of gelucire-based NPs (128-183 nm) were five times lower than control NPs (made without gelucire). All the NPs (with or without gelucire component) did not activate macrophages as monitored by reactive oxygen species production. Results from differential scanning calorimetry, FT-IR and multimodal light scattering measurements demonstrated the involvement of gelucire component in achieving homogeneous CA/gelucire particle populations that were stable on storage. The

Subject

Animals; ATP Binding Cassette Transporter; Calorimetry; Differential Scanning; Drug Carriers/*chemical synthesis/pharmacokinetics; Drug Stability; Emulsions/chemistry; Fatty Alcohols/*chemistry; Fourier Transform Infrared; Humans; Inbred BALB C; Macrophages/*drug effects/metabolism; Member 1/metabolism; Mice; Nanoparticles/*chemistry/ultrastructure; Oils/chemistry; Paclitaxel/pharmacokinetics; Particle Size; Polyethylene Glycols/*chemistry; Reactive Oxygen Species/metabolism; Rhodamine 123/metabolism; Spectroscopy; Subfamily B; Water/chemistry

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

259–265

Volume

94

Citation

Wehrung Daniel; Geldenhuys Werner J; Oyewumi Moses O, “Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions.,” NEOMED Bibliography Database, accessed June 19, 2021, https://neomed.omeka.net/items/show/3533.

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