Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease.

Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease.

Geldenhuys Werner J; Van der Schyf Cornelis J

Current topics in medicinal chemistry

2008

2008

Recently, the serotonin 5-HT(6) receptor has been identified as a drug target for attenuating cognitive deficits associated with Alzheimer's disease (AD). Additionally, this receptor may also play a role in schizophrenia, anxiety and obesity. Reports in the literature suggest that the production of selective antagonists for the 5-HT(6) receptor has increased during the last 10 years, with some compounds currently in clinical trials for the treatment of AD. In this review, we will address the rationale for using 5-HT(6) receptor antagonists in AD, as well as report on current advances in the understanding of the structure-activity relationships required to synthesize 5-HT(6) receptor antagonists.

Humans; Molecular Structure; Serotonin/*metabolism; Alzheimer Disease/*drug therapy; Serotonin Antagonists/chemistry/*therapeutic use; Nootropic Agents/chemistry/*therapeutic use; Receptors

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1035–1048

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