Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease.

Title

Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease.

Creator

Geldenhuys Werner J; Van der Schyf Cornelis J

Publisher

Current topics in medicinal chemistry

Date

2008
2008

Description

Recently, the serotonin 5-HT(6) receptor has been identified as a drug target for attenuating cognitive deficits associated with Alzheimer's disease (AD). Additionally, this receptor may also play a role in schizophrenia, anxiety and obesity. Reports in the literature suggest that the production of selective antagonists for the 5-HT(6) receptor has increased during the last 10 years, with some compounds currently in clinical trials for the treatment of AD. In this review, we will address the rationale for using 5-HT(6) receptor antagonists in AD, as well as report on current advances in the understanding of the structure-activity relationships required to synthesize 5-HT(6) receptor antagonists.

Subject

Humans; Molecular Structure; Serotonin/*metabolism; Alzheimer Disease/*drug therapy; Serotonin Antagonists/chemistry/*therapeutic use; Nootropic Agents/chemistry/*therapeutic use; Receptors

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1035–1048

Issue

12

Volume

8

Citation

Geldenhuys Werner J; Van der Schyf Cornelis J, “Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease.,” NEOMED Bibliography Database, accessed October 21, 2021, https://neomed.omeka.net/items/show/5075.

Social Bookmarking