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Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice.

AIMS: Irisin is a hormone cleaved from fibronectin type-III domain-containing protein 5 in response to exercise and may be therapeutic in Alzheimer's disease (AD). Irisin is shown to repair damage caused by midlife cardiometabolic risk factors for…

Comparative antiplatelet activity of COX1 NSAIDS versus aspirin, encompassing regimen simplification and gastroprotection: a call for a controlled study.

This study was conducted to assess the feasibility of COX1 NSAID substitution for aspirin for preventative therapy related to circulating anticoagulants, as manifest by inhibition of platelet aggregation. There was no difference in platelet…

Pharmacotherapy of Alzheimer's disease: current and future trends.

Alzheimer's disease (AD) and its related dementia has shown an alarming rise in the global population. Although considerable efforts have been made to develop effective therapeutic agents for AD therapy, drug development has not met significant…

Tags: 2015, Alzheimer Disease/*drug therapy, Alzheimer's disease, Anti-Inflammatory Agents, Antioxidants, cholinesterase inhibitors, Darvesh Altaf S, dementia, Department of Pharmaceutical Sciences, Drug Therapy/*methods/*trends, Expert review of neurotherapeutics, Geldenhuys Werner J, Humans, immunotherapy, memantine, multi-targeted drugs, natural products, NEOMED College of Pharmacy, Pharmacotherapy

Resveratrol and liver disease: from bench to bedside and community.

Liver diseases incorporate several maladies, which can range from benign histological changes to serious life-threatening conditions. These may include inborn metabolic disease, primary and metastatic cancers, alcoholic cirrhosis, viral hepatitis and…

Resveratrol inhibition of Propionibacterium acnes.

OBJECTIVES: To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium acnes growth. METHODS: Three different strains of P. acnes were tested against resveratrol at concentrations between 0 and 200 mg/L.…

Chemopreventive and therapeutic potential of tea polyphenols in hepatocellular cancer.

The prophylactic and therapeutic properties of tea have been attributed to green tea catechins and black tea theaflavins besides several other polyphenolic compounds. Tea polyphenols possess potent antioxidant and antiinflammatory properties and…

The health benefits of blackcurrants.

The blackcurrant (Ribes nigrum L., Grossulariceae), a small, perennial shrub native to central Europe and northern Asia, is cultivated throughout the world, including the United States. In addition to its anecdotal use in traditional herbal medicine,…

An update on inflammatory arthropathies including pharmacologic management and preoperative considerations.

This article provides an update and overview to the clinical presentations of inflammatory arthropathies. Subtleties to clinical presentations are discussed. Clues are presented which helps the reader arrive at more precise diagnostic labeling.…

Tags: *Preoperative Care, 2010, Anti-Inflammatory Agents, Antiinflammatory Agents, Arthritis – Diagnosis, Arthritis – Physiopathology, Arthritis – Therapy, Arthritis/diagnosis/physiopathology/*therapy, Clinics in podiatric medicine and surgery, Diagnosis, Differential, Foot – Physiopathology, Foot Diseases – Diagnosis, Foot Diseases – Therapy, Foot Diseases/diagnosis/*therapy, Foot Joints/physiopathology, Gout – Diagnosis, Gout – Physiopathology, Gout – Therapy, Gout Suppressants – Therapeutic Use, Gout Suppressants/therapeutic use, Gout/diagnosis/physiopathology/*therapy, Humans, Non-Steroidal – Therapeutic Use, Non-Steroidal/therapeutic use, Patient Selection, Physical Examination, Preoperative Care, Regule David, Synovitis – Diagnosis, Synovitis – Therapy, Synovitis/diagnosis/therapy, Uric Acid – Analysis, Uric Acid/analysis

Does preoperative rofecoxib (Vioxx) decrease postoperative pain with laparoscopic cholecystectomy?

BACKGROUND: A prospective, randomized, double-blinded clinical trial was designed to study the effects of preemptive rofecoxib (Vioxx) analgesia in patients undergoing elective laparoscopic cholecystectomy. METHODS: One hundred-twenty patients were…

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