Comparative antiplatelet activity of COX1 NSAIDS versus aspirin, encompassing regimen simplification and gastroprotection: a call for a controlled study.

Title

Comparative antiplatelet activity of COX1 NSAIDS versus aspirin, encompassing regimen simplification and gastroprotection: a call for a controlled study.

Creator

Rothschild B M

Publisher

Reumatismo

Date

2004
2004-06

Description

This study was conducted to assess the feasibility of COX1 NSAID substitution for aspirin for preventative therapy related to circulating anticoagulants, as manifest by inhibition of platelet aggregation. There was no difference in platelet aggregation inhibition between aspirin, naproxen, ketoprofen or diclofenac and misoprostol (in combination in the form of Arthrotec). As COX1 NSAIDs appear equivalent in platelet inhibition efficacy to aspirin, therapeutic regimens can be simplified in those individuals who require an NSAID for other problems. Further, despite its short serum halflife, Arthrotec appears as effective as an antiplatelet agent. Controlled, double blind studies of efficacy in blocking clinical events (both cardiovascular and gastrointestinal) are recommended.

Subject

Female; Humans; Male; Middle Aged; Time Factors; Feasibility Studies; Anti-Inflammatory Agents; Drug Combinations; Aspirin/administration & dosage/adverse effects/*therapeutic use; Cyclooxygenase Inhibitors/administration & dosage/adverse effects/*therapeutic use; Diclofenac/administration & dosage/adverse effects/*therapeutic use; Ketoprofen/administration & dosage/adverse effects/therapeutic use; Misoprostol/administration & dosage/adverse effects/*therapeutic use; Naproxen/administration & dosage/adverse effects/therapeutic use; Platelet Aggregation Inhibitors/administration & dosage/adverse effects/*therapeutic use; Stomach/drug effects; Non-Steroidal/administration & dosage/adverse effects/*therapeutic use

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

89–93

Issue

2

Volume

56

Citation

Rothschild B M, “Comparative antiplatelet activity of COX1 NSAIDS versus aspirin, encompassing regimen simplification and gastroprotection: a call for a controlled study.,” NEOMED Bibliography Database, accessed May 9, 2021, https://neomed.omeka.net/items/show/5209.

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