Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.

Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.

Geldenhuys Werner J; Bezuidenhout Lois-May; Dluzen Dean E

European journal of pharmacology

2009

2009-10

The dopamine transporter (DAT) plays an important role in substance abuse, schizophrenia, and dopaminergic toxicity associated with the Parkinsonian animal model toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Accordingly, the DAT serves as a critical component in regulating dopaminergic function in health and disease states. We have been working with a novel cage compound,

Animals; Biological Transport/drug effects; Buffers; Calcium Channels/metabolism; Dopamine Plasma Membrane Transport Proteins/metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Extracellular Space/*drug effects/*metabolism; In Vitro Techniques; Male; Methamphetamine/pharmacology; Mice; Neostriatum/*cytology/drug effects; PC12 Cells; Perfusion; Potassium Channel Blockers/pharmacology; Potassium Channels; Potassium Chloride/pharmacology; Rats; Voltage-Gated/antagonists & inhibitors

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

38–43

1

619