Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.

Title

Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.

Creator

Geldenhuys Werner J; Bezuidenhout Lois-May; Dluzen Dean E

Publisher

European journal of pharmacology

Date

2009
2009-10

Description

The dopamine transporter (DAT) plays an important role in substance abuse, schizophrenia, and dopaminergic toxicity associated with the Parkinsonian animal model toxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Accordingly, the DAT serves as a critical component in regulating dopaminergic function in health and disease states. We have been working with a novel cage compound,

Subject

Animals; Biological Transport/drug effects; Buffers; Calcium Channels/metabolism; Dopamine Plasma Membrane Transport Proteins/metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Extracellular Space/*drug effects/*metabolism; In Vitro Techniques; Male; Methamphetamine/pharmacology; Mice; Neostriatum/*cytology/drug effects; PC12 Cells; Perfusion; Potassium Channel Blockers/pharmacology; Potassium Channels; Potassium Chloride/pharmacology; Rats; Voltage-Gated/antagonists & inhibitors

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

38–43

Issue

1

Volume

619

Citation

Geldenhuys Werner J; Bezuidenhout Lois-May; Dluzen Dean E, “Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.,” NEOMED Bibliography Database, accessed September 23, 2021, https://neomed.omeka.net/items/show/3556.

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