Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Title

Creator

Sartelli Massimo; Weber Dieter G; Ruppe Etienne; Bassetti Matteo; Wright Brian J; Ansaloni Luca; Catena Fausto; Coccolini Federico; Abu-Zidan Fikri M; Coimbra Raul; Moore Ernest E; Moore Frederick A; Maier Ronald V; De Waele Jan J; Kirkpatrick Andrew W; Griffiths Ewen A; Eckmann Christian; Brink Adrian J; Mazuski John E; May Addison K; Sawyer Rob G; Mertz Dominik; Montravers Philippe; Kumar Anand; Roberts Jason A; Vincent Jean-Louis; Watkins Richard R; Lowman Warren; Spellberg Brad; Abbott Iain J; Adesunkanmi Abdulrashid Kayode; Al-Dahir Sara; Al-Hasan Majdi N; Agresta Ferdinando; Althani Asma A; Ansari Shamshul; Ansumana Rashid; Augustin Goran; Bala Miklosh; Balogh Zsolt J; Baraket Oussama; Bhangu Aneel; Beltran Marcelo A; Bernhard Michael; Biffl Walter L; Boermeester Marja A; Brecher Stephen M; Cherry-Bukowiec Jill R; Buyne Otmar R; Cainzos Miguel A; Cairns Kelly A; Camacho-Ortiz Adrian; Chandy Sujith J; Jusoh Asri Che; Chichom-Mefire Alain; Colijn Caroline; Corcione Francesco; Cui Yunfeng; Curcio Daniel; Delibegovic Samir; Demetrashvili Zaza; De Simone Belinda; Dhingra Sameer; Diaz Jose J; Di Carlo Isidoro; Dillip Angel; Di Saverio Salomone; Doyle Michael P; Dorj Gereltuya; Dogjani Agron; Dupont Herve; Eachempati Soumitra R; Enani Mushira Abdulaziz; Egiev Valery N; Elmangory Mutasim M; Ferrada Paula; Fitchett Joseph R; Fraga Gustavo P; Guessennd Nathalie; Giamarellou Helen; Ghnnam Wagih; Gkiokas George; Goldberg Staphanie R; Gomes Carlos Augusto; Gomi Harumi; Guzman-Blanco Manuel; Haque Mainul; Hansen Sonja; Hecker Andreas; Heizmann Wolfgang R; Herzog Torsten; Hodonou Adrien Montcho; Hong Suk-Kyung; Kafka-Ritsch Reinhold; Kaplan Lewis J; Kapoor Garima; Karamarkovic Aleksandar; Kees Martin G; Kenig Jakub; Kiguba Ronald; Kim Peter K; Kluger Yoram; Khokha Vladimir; Koike Kaoru; Kok Kenneth Y Y; Kong Victory; Knox Matthew C; Inaba Kenji; Isik Arda; Iskandar Katia; Ivatury Rao R; Labbate Maurizio; Labricciosa Francesco M; Laterre Pierre-Francois; Latifi Rifat; Lee Jae Gil; Lee Young Ran; Leone Marc; Leppaniemi Ari; Li Yousheng; Liang Stephen Y; Loho Tonny; Maegele Marc; Malama Sydney; Marei Hany E; Martin-Loeches Ignacio; Marwah Sanjay; Massele Amos; McFarlane Michael; Melo Renato Bessa; Negoi Ionut; Nicolau David P; Nord Carl Erik; Ofori-Asenso Richard; Omari AbdelKarim H; Ordonez Carlos A; Ouadii Mouaqit; Junior Gerson Alves Pereira; Piazza Diego; Pupelis Guntars; Rawson Timothy Miles; Rems Miran; Rizoli Sandro; Rocha Claudio; Sakakushev Boris; Sanchez-Garcia Miguel; Sato Norio; Segovia Lohse Helmut A; Sganga Gabriele; Siribumrungwong Boonying; Shelat Vishal G; Soreide Kjetil; Soto Rodolfo; Talving Peep; Tilsed Jonathan V; Timsit Jean Francois; Trueba Gabriel; Trung Ngo Tat; Ulrych Jan; van Goor Harry; Vereczkei Andras; Vohra Ravinder S; Wani Imtiaz; Uhl Waldemar; Xiao Yonghong; Yuan Kuo-Ching; Zachariah Sanoop K; Zahar Jean-Ralph; Zakrison Tanya L; Corcione Antonio; Melotti Rita M; Viscoli Claudio; Viale Perluigi

Publisher

World journal of emergency surgery : WJES

Date

2016

Description

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance. The overuse of antimicrobials is widely accepted as a major driver of some emerging infections (such as C. difficile), the selection of resistant pathogens in individual patients, and for the continued development of antimicrobial resistance globally. The growing emergence of multi-drug resistant organisms and the limited development of new agents available to counteract them have caused an impending crisis with alarming implications, especially with regards to Gram-negative bacteria. An international task force from 79 different countries has joined this project by sharing a document on the rational use of antimicrobials for patients with IAIs. The project has been termed AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections). The authors hope that AGORA, involving many of the world's leading experts, can actively raise awareness in health workers and can improve prescribing behavior in treating IAIs.

Subject

*International Cooperation; *Intraabdominal Infections/diagnosis/drug therapy/microbiology; Anti-Infective Agents/*pharmacology; Drug Resistance; Humans; Microbial; Microbial Sensitivity Tests; Prognosis

Identifier

10.1186/s13017-016-0089-y

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

URL Address

http://doi.org/10.1186/s13017-016-0089-y

Pages

33–33

Volume

Tags

*International Cooperation, *Intraabdominal Infections/diagnosis/drug therapy/microbiology, 2016, Abbott Iain J, Abu-Zidan Fikri M, Adesunkanmi Abdulrashid Kayode, Agresta Ferdinando, Al-Dahir Sara, Al-Hasan Majdi N, Althani Asma A, Ansaloni Luca, Ansari Shamshul, Ansumana Rashid, Anti-Infective Agents/*pharmacology, Augustin Goran, Bala Miklosh, Balogh Zsolt J, Baraket Oussama, Bassetti Matteo, Beltran Marcelo A, Bernhard Michael, Bhangu Aneel, Biffl Walter L, Boermeester Marja A, Brecher Stephen M, Brink Adrian J, Buyne Otmar R, Cainzos Miguel A, Cairns Kelly A, Camacho-Ortiz Adrian, Catena Fausto, Chandy Sujith J, Cherry-Bukowiec Jill R, Chichom-Mefire Alain, Coccolini Federico, Coimbra Raul, Colijn Caroline, Corcione Antonio, Corcione Francesco, Cui Yunfeng, Curcio Daniel, De Simone Belinda, De Waele Jan J, Delibegovic Samir, Demetrashvili Zaza, Department of Internal Medicine, Dhingra Sameer, Di Carlo Isidoro, Di Saverio Salomone, Diaz Jose J, Dillip Angel, Dogjani Agron, Dorj Gereltuya, Doyle Michael P, Drug Resistance, Dupont Herve, Eachempati Soumitra R, Eckmann Christian, Egiev Valery N, Elmangory Mutasim M, Enani Mushira Abdulaziz, Ferrada Paula, Fitchett Joseph R, Fraga Gustavo P, Ghnnam Wagih, Giamarellou Helen, Gkiokas George, Goldberg Staphanie R, Gomes Carlos Augusto, Gomi Harumi, Griffiths Ewen A, Guessennd Nathalie, Guzman-Blanco Manuel, Hansen Sonja, Haque Mainul, Hecker Andreas, Heizmann Wolfgang R, Herzog Torsten, Hodonou Adrien Montcho, Hong Suk-Kyung, Humans, Inaba Kenji, Isik Arda, Iskandar Katia, Ivatury Rao R, Junior Gerson Alves Pereira, Jusoh Asri Che, Kafka-Ritsch Reinhold, Kaplan Lewis J, Kapoor Garima, Karamarkovic Aleksandar, Kees Martin G, Kenig Jakub, Khokha Vladimir, Kiguba Ronald, Kim Peter K, Kirkpatrick Andrew W, Kluger Yoram, Knox Matthew C, Koike Kaoru, Kok Kenneth Y Y, Kong Victory, Kumar Anand, Labbate Maurizio, Labricciosa Francesco M, Laterre Pierre-Francois, Latifi Rifat, Lee Jae Gil, Lee Young Ran, Leone Marc, Leppaniemi Ari, Li Yousheng, Liang Stephen Y, Loho Tonny, Lowman Warren, Maegele Marc, Maier Ronald V, Malama Sydney, Marei Hany E, Martin-Loeches Ignacio, Marwah Sanjay, Massele Amos, May Addison K, Mazuski John E, McFarlane Michael, Melo Renato Bessa, Melotti Rita M, Mertz Dominik, Microbial, Microbial Sensitivity Tests, Montravers Philippe, Moore Ernest E, Moore Frederick A, Negoi Ionut, NEOMED College of Medicine, Nicolau David P, Nord Carl Erik, Ofori-Asenso Richard, Omari AbdelKarim H, Ordonez Carlos A, Ouadii Mouaqit, Piazza Diego, Prognosis, Pupelis Guntars, Rawson Timothy Miles, Rems Miran, Rizoli Sandro, Roberts Jason A, Rocha Claudio, Ruppe Etienne, Sakakushev Boris, Sanchez-Garcia Miguel, Sartelli Massimo, Sato Norio, Sawyer Rob G, Segovia Lohse Helmut A, Sganga Gabriele, Shelat Vishal G, Siribumrungwong Boonying, Soreide Kjetil, Soto Rodolfo, Spellberg Brad, Talving Peep, Tilsed Jonathan V, Timsit Jean Francois, Trueba Gabriel, Trung Ngo Tat, Uhl Waldemar, Ulrych Jan, van Goor Harry, Vereczkei Andras, Viale Perluigi, Vincent Jean-Louis, Viscoli Claudio, Vohra Ravinder S, Wani Imtiaz, Watkins Richard R, Weber Dieter G, World journal of emergency surgery : WJES, Wright Brian J, Xiao Yonghong, Yuan Kuo-Ching, Zachariah Sanoop K, Zahar Jean-Ralph, Zakrison Tanya L

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