Molecular, phenotypic aspects and therapeutic horizons of rare genetic bone disorders.

Title

Molecular, phenotypic aspects and therapeutic horizons of rare genetic bone disorders.

Creator

Faruqi Taha; Dhawan Naveen; Bahl Jaya; Gupta Vineet; Vohra Shivani; Tu Khin; Abdelmagid Samir M

Publisher

BioMed research international

Date

2014
1905-07

Description

A rare disease afflicts less than 200,000 individuals, according to the National Organization for Rare Diseases (NORD) of the United States. Over 6,000 rare disorders affect approximately 1 in 10 Americans. Rare genetic bone disorders remain the major causes of disability in US patients. These rare bone disorders also represent a therapeutic challenge for clinicians, due to lack of understanding of underlying mechanisms. This systematic review explored current literature on therapeutic directions for the following rare genetic bone disorders: fibrous dysplasia, Gorham-Stout syndrome, fibrodysplasia ossificans progressiva, melorheostosis, multiple hereditary exostosis, osteogenesis imperfecta, craniometaphyseal dysplasia, achondroplasia, and hypophosphatasia. The disease mechanisms of Gorham-Stout disease, melorheostosis, and multiple hereditary exostosis are not fully elucidated. Inhibitors of the ACVR1/ALK2 pathway may serve as possible therapeutic intervention for FOP. The use of bisphosphonates and IL-6 inhibitors has been explored to be useful in the treatment of fibrous dysplasia, but more research is warranted. Cell therapy, bisphosphonate polytherapy, and human growth hormone may avert the pathology in osteogenesis imperfecta, but further studies are needed. There are still no current effective treatments for these bone disorders; however, significant promising advances in therapeutic modalities were developed that will limit patient suffering and treat their skeletal disabilities.

Subject

Bone and Bones/*physiopathology; Bone Diseases/*epidemiology/genetics; Humans; Osteogenesis/genetics; Rare Diseases/*epidemiology/genetics

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

670842–670842

Volume

2014

Citation

Faruqi Taha; Dhawan Naveen; Bahl Jaya; Gupta Vineet; Vohra Shivani; Tu Khin; Abdelmagid Samir M, “Molecular, phenotypic aspects and therapeutic horizons of rare genetic bone disorders.,” NEOMED Bibliography Database, accessed March 3, 2021, https://neomed.omeka.net/items/show/4701.

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