Sirtuin 1 signaling and alcoholic fatty liver disease.

Title

Sirtuin 1 signaling and alcoholic fatty liver disease.

Creator

You Min; Jogasuria Alvin; Taylor Charles; Wu Jiashin

Publisher

Hepatobiliary surgery and nutrition

Date

2015
2015-04

Description

Alcoholic fatty liver disease (AFLD) is one of the most prevalent forms of liver disease worldwide and can progress to inflammation (hepatitis), fibrosis/cirrhosis, and ultimately lead to end stage liver injury. The mechanisms, by which ethanol consumption leads to AFLD, are complicated and multiple, and remain incompletely understood. Nevertheless, understanding its pathogenesis will facilitate the development of effective pharmacological or nutritional therapies for treating human AFLD. Chronic ethanol consumption causes steatosis and inflammation in rodents or humans by disturbing several important hepatic transcriptional regulators, including AMP-activated kinase (AMPK), lipin-1, sterol regulatory element binding protein 1 (SREBP-1), PPARgamma co-activator-1alpha (PGC-1alpha), and nuclear transcription factor-kappaB (NF-kappaB). Remarkably, the effects of ethanol on these regulators are mediated in whole or in part by inhibition of a central signaling molecule, sirtuin 1 (SIRT1), which is a nicotinamide adenine dinucleotide (NAD(+), NADH)-dependent class III protein deacetylase. In recent years, SIRT1 has emerged as a pivotal molecule controlling the pathways of hepatic lipid metabolism, inflammatory responses and in the development of AFLD in rodents and in humans. Ethanol-mediated SIRT1 inhibition suppresses or stimulates the activities of above described transcriptional regulators and co-regulators, thereby deregulating diverse lipid metabolism and inflammatory response pathways including lipogenesis, fatty acid beta-oxidation, lipoprotein uptake and secretion and expression of pro-inflammatory cytokines in the liver. This review aims to highlight our current understanding of SIRT1 regulatory mechanisms and its response to ethanol-induced toxicity, thus, affirming significant role of SIRT1 signaling in the development of AFLD.

Subject

lipid metabolism; inflammation; signal transduction; transcriptional regulators; alcoholic fatty liver; Sirtuin 1 (SIRT1)

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

88–100

Issue

2

Volume

4

Citation

You Min; Jogasuria Alvin; Taylor Charles; Wu Jiashin, “Sirtuin 1 signaling and alcoholic fatty liver disease.,” NEOMED Bibliography Database, accessed May 17, 2021, https://neomed.omeka.net/items/show/5200.

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