Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage.

Title

Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage.

Creator

Horton W E Jr; Yagi R; Laverty D; Weiner S

Publisher

Clinical and experimental rheumatology

Date

2005
2005-02

Description

A major area under study in the osteoarthritis (OA) research field is the characterization of specific molecular and biochemical changes that distinguish advanced diseased cartilage from less involved or normal tissue. This information is important to better define the pathogenic mechanisms that are operating during OA progression and to identify disease-specific markers. This review describes recent studies that have addressed changes in chondrocyte gene expression, proliferation, and apoptosis in "experimental" (more advanced OA cartilage) versus "control" (less involved or non-OA cartilage). Included is a comprehensive listing of recently published studies in this area with general findings. The review also includes a discussion of study design and the strengths and weaknesses of the various approaches. In addition, specific strategies to deal with some of the important issues are discussed. One particular model utilizing minimal and advanced OA cartilage obtained from the same patient is described in more detail.

Subject

Humans; Cell Proliferation; Apoptosis/physiology; Gene Expression/physiology; Cartilage; Cartilage Diseases/*physiopathology; Chondrocytes/physiology; Osteoarthritis/*physiopathology; Biological; Models; Articular/*physiopathology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

103–112

Issue

1

Volume

23

Citation

Horton W E Jr; Yagi R; Laverty D; Weiner S, “Overview of studies comparing human normal cartilage with minimal and advanced osteoarthritic cartilage.,” NEOMED Bibliography Database, accessed September 23, 2021, https://neomed.omeka.net/items/show/5459.

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