Cinacalcet for the treatment of primary hyperparathyroidism.

Title

Cinacalcet for the treatment of primary hyperparathyroidism.

Creator

Dillon ML; Frazee L A

Publisher

American Journal of Therapeutics

Date

2011
2011-07

Description

The objective of this article is to review the literature regarding the treatment of primary hyperparathyroidism (PHPT) with a focus on cinacalcet. A MEDLINE (1965-June 2009) and bibliographic search of the English-language literature was conducted using the search terms cinacalcet, calcimimetics, primary hyperparathyroidism, and treatment. All articles identified in the search were included. Parathyroidectomy is curative for patients with PHPT; however, there are few options for patients who are not surgical candidates, who refuse surgery, or those with refractory PHPT after parathyroidectomy. Possible treatment options include estrogens, raloxifene, bisphosphonates, calcitonin, and cinacalcet. Cinacalcet has been shown to decrease serum calcium and parathyroid hormone serum levels in patients with PHPT. These trials, however, have not studied the effect of cinacalcet on patient-oriented outcomes such as bone mineral density, nephrolithiasis, or other complications of PHPT. Cinacalcet may be considered to reduce serum calcium and parathyroid hormone serum levels in patients with PHPT who cannot or will not undergo surgery and those with refractory PHPT after parathyroidectomy. Because the effects of cinacalcet on bone mineral density are uncertain, more frequent monitoring of bone mineral density may be required along with a medication proven to improve bone mineral density. Future studies should evaluate the effect of cinacalcet on complications of PHPT.

Subject

Female; Hormone Replacement Therapy; Hydrocarbons – Therapeutic Use; Bone Density – Drug Effects; Calcitonin – Therapeutic Use; Diphosphonates – Therapeutic Use; Estrogens – Therapeutic Use; Hormone Antagonists – Pharmacodynamics; Hormone Antagonists – Therapeutic Use; Hydrocarbons – Pharmacodynamics; Hyperparathyroidism – Complications; Hyperparathyroidism – Drug Therapy; Osteoporosis – Drug Therapy; Osteoporosis – Etiology; Raloxifene – Therapeutic Use

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

313–322

Issue

4

Volume

18

Citation

Dillon ML; Frazee L A, “Cinacalcet for the treatment of primary hyperparathyroidism.,” NEOMED Bibliography Database, accessed March 1, 2021, https://neomed.omeka.net/items/show/5988.

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