Neuropathological Findings in Susac Syndrome: An Autopsy Report
Title
Neuropathological Findings in Susac Syndrome: An Autopsy Report
Creator
Agamanolis Dimitri P; Klonk Collin; Bigley Kim; Rennebohm Robert M
Publisher
Journal of Neuropathology and Experimental Neurology
Date
2019
2019-06
Description
A 24-year-old woman developed encephalopathy, branch retinal artery occlusion, hearing loss, and had "snowball" lesions in the corpus callosum, classic findings of Susac syndrome (SuS). Despite intensive immunosuppressive therapy, she lapsed into a coma, and died 7 months after the onset of her illness. Neuropathological examination, revealed perivascular inflammation and vasculitis involving small vessels, associated with vascular narrowing and occlusion, and numerous microinfarcts diffusely throughout the brain. The findings establish SuS as a neuroinflammatory condition that can include vasculitis. This represents the most comprehensive report of the neuropathological findings in SuS.
Subject
Cerebral vasculitis; Deafness; Encephalopathy; Susac syndrome; Visual loss
Identifier
URL Address
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
515-519
Issue
6
Volume
78
Citation
Agamanolis Dimitri P; Klonk Collin; Bigley Kim; Rennebohm Robert M, “Neuropathological Findings in Susac Syndrome: An Autopsy Report,” NEOMED Bibliography Database, accessed June 6, 2023, https://neomed.omeka.net/items/show/6364.