Prospects for the Pharmacological Prevention of Post-Traumatic Stress in Vulnerable Individuals

Title

Prospects for the Pharmacological Prevention of Post-Traumatic Stress in Vulnerable Individuals

Creator

Ostrowski S A; Delahanty D L

Publisher

Cns Drugs

Date

2014
2014-03

Description

Biological studies of posttraumatic stress disorder (PTSD) have found alterations of physiological stress pathways [sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis] soon after trauma in individuals who have subsequently developed PTSD, leading researchers to hypothesize that pharmacological manipulation of stress hormone levels may aid in preventing the development of post-traumatic distress. The present paper first reviews the current understanding of the neurobiology of PTSD development and then provides the rationale and evidence for early pharmacological strategies to prevent/reduce post-traumatic distress in at-risk trauma victims. Emphasis is placed on those interventions targeting the SNS and the HPA axis. Furthermore, in light of recent calls to move away from categorical diagnostic outcomes, we discuss how examining post-traumatic distress from a transdiagnostic viewpoint may inform novel chemoprophylactic approaches (intervening pharmacologically after trauma to prevent post-traumatic distress). Current evidence is suggestive for medications, such as propranolol, hydrocortisone, morphine, and oxytocin, impacting early stress hormone levels and subsequent risk for post-traumatic distress; however, future research is needed prior to adapting recommendations for widespread use of any chemoprophylactic treatments.

Subject

civilian trauma victims; conditioned fear; controlled trial; cortisol-levels; declarative memory; glucocorticoid-induced impairment; motor-vehicle accident; national comorbidity survey; Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry; ptsd symptoms; quality-of-life; randomized

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

195-203

Issue

3

Volume

28

Citation

Ostrowski S A; Delahanty D L, “Prospects for the Pharmacological Prevention of Post-Traumatic Stress in Vulnerable Individuals,” NEOMED Bibliography Database, accessed March 4, 2021, https://neomed.omeka.net/items/show/6696.

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