Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons

Title

Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons

Creator

Ourednik J; Ourednik V; Lynch W P; Schachner M; Snyder E Y

Publisher

Nature Biotechnology

Date

2002
2002-11

Description

We investigated the hypothesis that neural stem cells (NSCs) possess an intrinsic capacity to "rescue" dysfunctional neurons in the brains of aged mice. The study focused on a neuronal cell type with stereotypical projections that is commonly compromised in the aged brain-the dopaminergic (DA) neuron. Unilateral implantation of murine NSCs into the midbrains of aged mice, in which the presence of stably impaired but nonapoptotic DA neurons was increased by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was associated with bilateral reconstitution of the mesostriatal system. Functional assays paralleled the spatiotemporal recovery of tyrosine hydroxylase (TH) and dopamine transporter (DAT) activity, which, in turn, mirrored the spatiotemporal distribution of donor-derived cells. Although spontaneous conversion of donor NSCs to TH+ cells contributed to nigral reconstitution in DA-depleted areas, the majority of DA neurons in the mesostriatal system were "rescued" host cells. Undifferentiated donor progenitors spontaneously expressing neuroprotective substances provided a plausible molecular basis for this finding. These observations suggest that host structures may benefit not only from NSC-derived replacement of lost neurons but also from the "chaperone" effect of some NSC-derived progeny.

Subject

1-methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine mptp; adult brain; Biotechnology & Applied Microbiology; central-nervous-system; dopaminergic; gene-transfer; growth factor; juvenile neocortex; mouse-brain; neurotoxicity; parkinsons-disease; replacement

Identifier

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1103-1110

Issue

11

Volume

20

Citation

Ourednik J; Ourednik V; Lynch W P; Schachner M; Snyder E Y, “Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons,” NEOMED Bibliography Database, accessed February 28, 2021, https://neomed.omeka.net/items/show/6699.

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