MEDIAL CALCIFICATION (WHITLOCKITE) IN THE AORTA

Title

MEDIAL CALCIFICATION (WHITLOCKITE) IN THE AORTA

Creator

Reid J D; Andersen M E

Publisher

Atherosclerosis

Date

1993
1993-07

Description

Calcified deposits in the tunica media of the human aorta have been studied in 128 cases by light microscopy and by electron microscopy and analytical methods in selected samples. Although dissolved and not visible in routine histology with alum hematoxylin stains, such calcification can be clearly seen after methylene blue staining in the form of unstained refractile particles of 1-2 mum size. These are found between the elastic laminae chiefly in the inner two-thirds of the media and appear at about age 20. By X-ray diffraction supported by energy dispersive X-ray analysis, they have been identified as whitlockite (Ca,Mg)3(PO4)2. Statistical analysis shows a significant increase in numbers with age and significant differences in severity related to county of origin but no differences between sexes or races and no correlation with deaths related to cardiovascular diseases. Among various substructures of the aortic wall, no unique crystal precursor was identified. Possible etiologic factors and clinicopathologic significance are considered.

Subject

aorta; atheroma; calcium; Cardiovascular System & Cardiology; drinking water; elastin; matrix vesicles; whitlockite

Format

Journal Article

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

213-224

Issue

2

Volume

101

Citation

Reid J D; Andersen M E, “MEDIAL CALCIFICATION (WHITLOCKITE) IN THE AORTA,” NEOMED Bibliography Database, accessed July 28, 2021, https://neomed.omeka.net/items/show/6857.

Social Bookmarking