ONTOGENY OF THE DEPRESSANT ACTIVITY OF CARBACHOL ON SYNAPTIC ACTIVITY IN RAT VISUAL-CORTEX
Title
ONTOGENY OF THE DEPRESSANT ACTIVITY OF CARBACHOL ON SYNAPTIC ACTIVITY IN RAT VISUAL-CORTEX
Creator
Vaknin G; Teyler T J
Publisher
Brain Research Bulletin
Date
1991
1991-02
Description
We studied the ontogeny of muscarinic depression in the developing rat visual cortex using carbachol (a nonhydrolyzable cholinergic agonist) application to neocortical slices obtained from four postnatal age groups: 9-10 days, 15 days, 30-40 days and 18 months. Carbachol suppressed the evoked synaptic response of layers II-III to stimulation of layer II-III afferents. Atropine eliminated the carbachol effect, suggesting that it is mediated by muscarinic receptors. The results indicate a significant increase in muscarinic efficacy in the developing rat visual cortex.
Subject
acetylcholine; area; brain; carbachol; hippocampus; muscarinic receptors; Neurosciences & Neurology; ontogeny; visual cortex
Identifier
Format
Journal Article
URL Address
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Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
211-214
Issue
2
Volume
26
Citation
Vaknin G; Teyler T J, “ONTOGENY OF THE DEPRESSANT ACTIVITY OF CARBACHOL ON SYNAPTIC ACTIVITY IN RAT VISUAL-CORTEX,” NEOMED Bibliography Database, accessed April 26, 2024, https://neomed.omeka.net/items/show/7382.