ONTOGENY OF THE DEPRESSANT ACTIVITY OF CARBACHOL ON SYNAPTIC ACTIVITY IN RAT VISUAL-CORTEX

Title

ONTOGENY OF THE DEPRESSANT ACTIVITY OF CARBACHOL ON SYNAPTIC ACTIVITY IN RAT VISUAL-CORTEX

Creator

Vaknin G; Teyler T J

Publisher

Brain Research Bulletin

Date

1991
1991-02

Description

We studied the ontogeny of muscarinic depression in the developing rat visual cortex using carbachol (a nonhydrolyzable cholinergic agonist) application to neocortical slices obtained from four postnatal age groups: 9-10 days, 15 days, 30-40 days and 18 months. Carbachol suppressed the evoked synaptic response of layers II-III to stimulation of layer II-III afferents. Atropine eliminated the carbachol effect, suggesting that it is mediated by muscarinic receptors. The results indicate a significant increase in muscarinic efficacy in the developing rat visual cortex.

Subject

acetylcholine; area; brain; carbachol; hippocampus; muscarinic receptors; Neurosciences & Neurology; ontogeny; visual cortex

Format

Journal Article

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

211-214

Issue

2

Volume

26

Citation

Vaknin G; Teyler T J, “ONTOGENY OF THE DEPRESSANT ACTIVITY OF CARBACHOL ON SYNAPTIC ACTIVITY IN RAT VISUAL-CORTEX,” NEOMED Bibliography Database, accessed May 10, 2021, https://neomed.omeka.net/items/show/7382.

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