Type 1 Cryoglobulinemia Response to Thalidomide and Lenalidomide

Title

Type 1 Cryoglobulinemia Response to Thalidomide and Lenalidomide

Creator

Calabrese C; Faiman B; Martin D; Reu F; Calabrese L H

Publisher

Jcr-Journal of Clinical Rheumatology

Date

2011
2011-04

Description

Among the varying etiologies of cryoglobulinemia (Cg), type I Cg represents the rarest form and is most often associated with lymphoproliferative disorders such as non-Hodgkin lymphoma, Waldenstrom macroglobulinemia, or multiple myeloma. Clinical manifestations are generally those of small-vessel vasculitis and/or hyperviscosity. The treatment of patients with type 1 disease generally consists of chemotherapy directed at the lymphoproliferative disorder or varying levels of empiric immunosuppression including apheresis, glucocorticoids, and cytotoxic agents. In recent years, anecdotes of biologic and/or immunomodulatory therapy with rituximab and thalidomide have been reported.(1-4) Occasionally. patients present with severe type 1 cryoglobulinemic disease in the absence of a defined malignancy but with monoclonal gammopathy of otherwise undetermined significance (MGUS); the treatment of such patients is controversial.(5,6) We recently treated such a patient with traditional immunosuppressives and rituximab but found him ultimately to respond only to thalidomide and its congener, lenalidomide.

Subject

therapy; Rheumatology; patient; criteria; imids; multiple-myeloma; poems-syndrome; vasculitis; waldenstroms macroglobulinemia

Format

Journal Article or Conference Abstract Publication

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

145-147

Issue

3

Volume

17

Citation

Calabrese C; Faiman B; Martin D; Reu F; Calabrese L H, “Type 1 Cryoglobulinemia Response to Thalidomide and Lenalidomide,” NEOMED Bibliography Database, accessed September 21, 2021, https://neomed.omeka.net/items/show/8786.

Social Bookmarking