Systemic consequences of oxidative stress following aortic surgery correlate with the degree of antioxidant defenses

Title

Systemic consequences of oxidative stress following aortic surgery correlate with the degree of antioxidant defenses

Creator

Cornu-Labat G; Serra M; Smith A; McGregor W E; Kasirajan K; Hirko M K; Turner J J; Rubin J R

Publisher

Annals of Vascular Surgery

Date

2000
2000-01

Description

The purpose of this study was to correlate the preoperative level of antioxidant defenses, measured by the plasma total antioxidant capacity (TAC), to the degree of postoperative systemic inflammatory response, measured by the severity of pulmonary injury following elective aortic surgery. Twenty-four patients had TAC measured preoperatively and 24 hr postoperatively. Chest radiography and arterial blood gases were obtained preoperatively and serially during the first 24 hr after surgery. Using objective radiologic criteria and blood gas analysis, the degree of pulmonary edema and pulmonary dysfunction were quantified. All patients showed evidence of pulmonary dysfunction in the first 24 hr following surgery. Fifteen of the 24 patients showed radiographic evidence of noncardiogenic pulmonary edema in the immediate postoperative period. In this group, the TAC was lower than in those without pulmonary edema immediately following surgery (p = 0.03). Preoperative TAC was associated with the degree of pulmonary edema in the postoperative period (r = -0.372, p = 0.067). These results suggest that preoperative antioxidant supplementation may favorably impact the severity of systemic inflammatory response following ischemia and reperfusion injury. DOI: 10.1007/s100169910006.

Subject

Surgery; oxygen; pulmonary-edema; Cardiovascular System & Cardiology; capacity; ischemia-reperfusion injury; radicals; lung injury; depletion; mediators; xanthine-oxidase

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

31-36

Issue

1

Volume

14

Citation

Cornu-Labat G; Serra M; Smith A; McGregor W E; Kasirajan K; Hirko M K; Turner J J; Rubin J R, “Systemic consequences of oxidative stress following aortic surgery correlate with the degree of antioxidant defenses,” NEOMED Bibliography Database, accessed March 1, 2021, https://neomed.omeka.net/items/show/8972.

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