The effects of low dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic shock

Title

The effects of low dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic shock

Creator

MeierHellmann A; Bredle D L; Specht M; Spies C; Hannemann L; Reinhart K

Publisher

Intensive Care Medicine

Date

1997
1997-01

Description

Objective. To assess the effects of low-dose dopamine on splanchnic blood flow and splanchnic oxygen uptake in patients with septic shock. Design. Prospective, controlled trial. Setting. University hospital intensive care unit. Patients. 11 patients with septic shock, diagnosed according the criteria of the 1992 American College of Chest Physicians/Society of Critical Care Medicine consensus conference, who required treatment with norepinephrine. Measurements and main results: Systemic and splanchnic hemodynamics and oxygen transport were measured before and during addition of low-dose dopamine (3 mu g/kg per min). Low-dose dopamine had a marked effect on total body hemodynamics and oxygen transport. The fractional splanchnic flow at baseline ranged from 0.15 to 0.57. In 7 patients with a fractional splanchnic flow less than 0.30, low-dose dopamine increased splanchnic flow and splanchnic oxygen delivery and oxygen consumption. In 4 patients with a fractional splanchnic flow above 0.30, low-dose dopamine did not appear to change splanchnic blood flow. Conclusion: Low-dose dopamine has a potential beneficial effect on splanchnic blood flow and oxygen consumption in patients with septic shock, provided the fractional splanchnic flow is not already high before treatment.

Subject

sepsis; injury; oxygen consumption; General & Internal Medicine; epinephrine; dopamine; index; septic shock; oxygen delivery; critically ill patients; consumption; blood flow; endotoxemia; gastric-mucosal ph; indocyanine green; splanchnic; splanchnic oxygen; splanchnic oxygen delivery

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

31-37

Issue

1

Volume

23

Citation

MeierHellmann A; Bredle D L; Specht M; Spies C; Hannemann L; Reinhart K, “The effects of low dose dopamine on splanchnic blood flow and oxygen uptake in patients with septic shock,” NEOMED Bibliography Database, accessed May 16, 2021, https://neomed.omeka.net/items/show/9091.

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