Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters

Title

Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters

Creator

Montgomery K; Corona C; Frye R; Barnett R; Bailey A; Fitsanakis V A

Publisher

Neurotoxicology and Teratology

Date

2018
2018-07

Description

Mancozeb (MZ), an organic-metal fungicide used predominantly on vegetables and fruits, has been linked to neurodegeneration and behavioral disruptions in a variety of organisms, including humans. Both gamma-aminobutyric acid and dopamine neurons appear to be more vulnerable to MZ exposure than other neuronal populations. Based on these observations, we hypothesized that MZ may be differentially transported into these cells through their presynaptic neurotransmitter transporters. To test this, we pretreated Caenorhabditis elegans with transporter antagonists followed by exposure to various concentrations of MZ. Potential neuroprotection was monitored via green fluorescence associated with various neuron populations in transgenic worm strains. Neurodegeneration associated with subacute MZ treatment (30 min) was not altered by transporter antagonist pretreatment. On the other hand, pretreatment with a dopamine transporter antagonist (GBR12909) appeared to protect dopaminergic neurons from chronic (24 h) MZ treatment. These results are consistent with other reports that dopamine transporter levels or activity may modulate toxicity for neurotoxicants.

Subject

C. elegans; Toxicology; Neurosciences & Neurology; parkinsons-disease; exposure; degeneration; costa-rica; pregnant-women; antidepressant; caenorhabditis-elegans; infants environmental-health; leads; Mancozeb; Mancozeb; Manzate; Mn/Zn ethylene-bis-dithiocarbamate; Neurotransmitter transporters; Neurotransmitters

Format

Journal Article or Conference Abstract Publication

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Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

66-71

Volume

68

Citation

Montgomery K; Corona C; Frye R; Barnett R; Bailey A; Fitsanakis V A, “Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters,” NEOMED Bibliography Database, accessed January 24, 2021, https://neomed.omeka.net/items/show/9164.

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