Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters
Title
Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters
Creator
Montgomery K; Corona C; Frye R; Barnett R; Bailey A; Fitsanakis V A
Publisher
Neurotoxicology and Teratology
Date
2018
2018-07
Description
Mancozeb (MZ), an organic-metal fungicide used predominantly on vegetables and fruits, has been linked to neurodegeneration and behavioral disruptions in a variety of organisms, including humans. Both gamma-aminobutyric acid and dopamine neurons appear to be more vulnerable to MZ exposure than other neuronal populations. Based on these observations, we hypothesized that MZ may be differentially transported into these cells through their presynaptic neurotransmitter transporters. To test this, we pretreated Caenorhabditis elegans with transporter antagonists followed by exposure to various concentrations of MZ. Potential neuroprotection was monitored via green fluorescence associated with various neuron populations in transgenic worm strains. Neurodegeneration associated with subacute MZ treatment (30 min) was not altered by transporter antagonist pretreatment. On the other hand, pretreatment with a dopamine transporter antagonist (GBR12909) appeared to protect dopaminergic neurons from chronic (24 h) MZ treatment. These results are consistent with other reports that dopamine transporter levels or activity may modulate toxicity for neurotoxicants.
Subject
C. elegans; Toxicology; Neurosciences & Neurology; parkinsons-disease; exposure; degeneration; costa-rica; pregnant-women; antidepressant; caenorhabditis-elegans; infants environmental-health; leads; Mancozeb; Mancozeb; Manzate; Mn/Zn ethylene-bis-dithiocarbamate; Neurotransmitter transporters; Neurotransmitters
Identifier
Format
Journal Article or Conference Abstract Publication
URL Address
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Rights
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Pages
66-71
Volume
68
Citation
Montgomery K; Corona C; Frye R; Barnett R; Bailey A; Fitsanakis V A, “Transport of a manganese/zinc ethylene-bis-dithiocarbamate fungicide may involve pre-synaptic dopaminergic transporters,” NEOMED Bibliography Database, accessed February 16, 2025, https://neomed.omeka.net/items/show/9164.